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LPS Antibody (MA5-41631) in IHC (P)
Immunohistochemistry analysis of Lipopolysaccharide in paraffin-embedded Rat Small intestine tissue. Samples were incubated with monoclonal antibody (Product # MA5-41631) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG using a dilution of 2 µg/mL.
Product Details
MA5-41631
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C6
Immunogen
OVA Conjugated Lipopolysaccharide (LPS) from Escherichia coli (O55:B5)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899113
Target Information
Lipopolysaccharide (LPS) is a large molecule found in the outer membrane of Gram-negative bacteria, serving as a potent endotoxin. Structurally, LPS is composed of three regions: the lipid A, core oligosaccharide, and O antigen polysaccharide. Lipid A, consisting of a phosphorylated glucosamine disaccharide with fatty acids, anchors LPS within the bacterial membrane and is largely responsible for its toxic effects. The core oligosaccharide links lipid A to the O antigen, which varies significantly among bacterial species and contributes to antigenic diversity. Functionally, LPS plays a crucial role in protecting bacteria from hostile environmental conditions while serving as a major factor in eliciting strong immune responses in host organisms. Once released into the bloodstream following bacterial cell lysis or infection, LPS activates immune cells by binding to Toll-like receptor 4 (TLR4), leading to the production of pro-inflammatory cytokines. This interaction can result in septic shock, characterized by widespread inflammation and cardiovascular collapse. Hence, understanding the biology and effects of LPS is critical for developing strategies to combat bacterial infections and manage sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LPS
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