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Invitrogen
LPXN Polyclonal Antibody
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LPXN Antibody (PA5-79610) in IHC (P)
Immunohistochemical analysis of Leupaxin in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-Leupaxin antibody (Product # PA5-79610) overnight at 4°C. Biotinylated goat anti... View More
Product Details
PA5-79610
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Leupaxin (115-129aa KKHLPDKQDHKASLD).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746725
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Raji whole cell, human PC-3 whole cell, human U87 whole cell, human MDA-MB-453 whole cell, mouse RAW2647 whole cell. Flow: Raji cell.
Target Information
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leupaxin
Gene Aliases: 4933402K05Rik; A530083L21Rik; AV278559; LDLP; LDPL; LPXN
UniProt ID: (Human) O60711, (Mouse) Q99N69
Entrez Gene ID: (Human) 9404, (Mouse) 107321
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
cell adhesion
negative regulation of cell adhesion
signal transduction
regulation of cell adhesion mediated by integrin
negative regulation of B cell receptor signaling pathway
regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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