Invitrogen

LRP1 Polyclonal Antibody

1 Published Figure

1 Reference

View all (48) LRP1 (CD91) antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (26)
Published Figures (1)

LRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 27

LRP1 Antibody (PA5-101013) in IHC (P)

Immunohistochemistry analysis of LRP1 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with LRP1 polyclonal antibody (Product # PA5-101013) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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Product Details

PA5-101013

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human LRP1(Accession Q07954), corresponding to amino acid residues L4494-A4544.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2850489

Product Specific Information

Antibody detects endogenous levels of total LRP1/CD91.

Target Information

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice.

Nature communications

Wan T,Zhu W,Zhao Y,Zhang X,Ye R,Zuo M,Xu P,Huang Z,Zhang C,Xie Y,Liu X

PA5-101013 was used in Western Blot to investigate the cytosolic function of lipocalin-2 and the related mechanisms involved in cell-specific activity and disease progression in regards to secondary demyelination.

Thu Mar 03 00:00:00 UTC 2022

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice.

Nature communications

Wan T,Zhu W,Zhao Y,Zhang X,Ye R,Zuo M,Xu P,Huang Z,Zhang C,Xie Y,Liu X

Thu Mar 03 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

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Gene Aliases: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5

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UniProt ID: (Human) Q07954, (Mouse) Q91ZX7, (Rat) G3V928

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Entrez Gene ID: (Human) 4035, (Mouse) 16971, (Rat) 299858

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Function(s)

protease binding receptor activity low-density lipoprotein receptor activity calcium ion binding protein binding protein complex binding apolipoprotein binding lipoprotein transporter activity poly(A) RNA binding lipoprotein particle receptor binding metal ion binding

Process(es)

endocytosis receptor-mediated endocytosis protein kinase C-activating G-protein coupled receptor signaling pathway multicellular organism development cholesterol metabolic process cell proliferation positive regulation of cholesterol efflux negative regulation of neuron projection development negative regulation of smooth muscle cell migration negative regulation of Wnt signaling pathway positive regulation of lipid transport regulation of cholesterol transport regulation of phospholipase A2 activity regulation of actin cytoskeleton organization aorta morphogenesis apoptotic cell clearance negative regulation of neuron apoptotic process positive regulation of protein transport beta-amyloid clearance negative regulation of platelet-derived growth factor receptor-beta signaling pathway retinoid metabolic process aging cerebral cortex development lipoprotein metabolic process lipoprotein transport

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LRP1 Polyclonal Antibody

LRP1 Antibody (PA5-101013) in IHC (P)

Product Details

PA5-101013

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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