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Invitrogen
LRP1 Monoclonal Antibody (A2Mr alpha-2)
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Product Details
MA1-80192
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
A2Mr alpha-2
Immunogen
Purified alpha2 macroglobulin receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_929727
Product Specific Information
MA1-80192 recognizes human CD91, a type I membrane protein which is also known as alpha-2 macroglobulin receptor (alpha2 MR). MA1-80192 recognizes an epitope in the extracellular region of the 500 kD alpha chain.
A suggested positive control for immunohistochemical applications is liver. Non-reducing conditions are recommended for Western blot applications. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; low density lipoprotein receptor-related protein 1; LRP-1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor
Gene Aliases: A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954
Entrez Gene ID: (Human) 4035
retinoid metabolic process
receptor-mediated endocytosis
protein kinase C-activating G-protein coupled receptor signaling pathway
aging
cell proliferation
positive regulation of cholesterol efflux
negative regulation of neuron projection development
negative regulation of smooth muscle cell migration
cerebral cortex development
negative regulation of Wnt signaling pathway
positive regulation of lipid transport
regulation of cholesterol transport
regulation of phospholipase A2 activity
regulation of actin cytoskeleton organization
aorta morphogenesis
lipoprotein metabolic process
lipoprotein transport
apoptotic cell clearance
negative regulation of neuron apoptotic process
positive regulation of protein transport
beta-amyloid clearance
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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