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Product Details
PA5-53568
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LRP12. Recombinant protein control fragment (Product #RP-90323).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2643475
Product Specific Information
Immunogen sequence: FPVCSPNQAS VLENLRLAVR SQLGFTSVRL PMAGRSSNIW NRIFNFARSR HSGSLALVSA DGDEVVPSQS TSREPERNHT HRSLFSVESD DTDTENERRD MAGASGGVAA PLPQKVPPTT AVEATVGACA SSS
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.
Target Information
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP12, also designated ST7, is a member of the LDLR family that is thought to be involved in the internalization of lipophilic molecules and/or signal transduction. LRP12 has been shown to interact with RACK1, MADHIP and Integrin beta-1-binding protein 3. It is widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. Overexpression of LRP12 may be associated with oral tumors, therefore implicating LRP12 as a potential oncogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LDLR-related protein 12; low density lipoprotein receptor-related protein 12; Low-density lipoprotein receptor-related protein 12; Suppressor of tumorigenicity 7 protein
Gene Aliases: LRP12; ST7
UniProt ID: (Human) Q9Y561
Entrez Gene ID: (Human) 29967
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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