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Abnova
LRP5 Monoclonal Antibody (1E9)
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Product Details
H00004041-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1E9
Immunogen
LRP5 (NP_002326.1, 41 a.a. approximately 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: RDVRLVDAGG VKLESTIVVS GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ NVVISGLVSP DGLACDWVGK KLYWTDSETN
Target Information
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7
Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2
UniProt ID: (Human) O75197
Entrez Gene ID: (Human) 4041
gastrulation with mouth forming second
positive regulation of mesenchymal cell proliferation
osteoblast development
glucose catabolic process
endocytosis
cholesterol metabolic process
regulation of blood pressure
positive regulation of cell proliferation
anterior/posterior pattern specification
Wnt signaling pathway
positive regulation of osteoblast proliferation
somatic stem cell population maintenance
extracellular matrix-cell signaling
cell migration involved in gastrulation
cholesterol homeostasis
embryonic digit morphogenesis
regulation of apoptotic process
Wnt signaling pathway involved in dorsal/ventral axis specification
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
bone remodeling
regulation of bone remodeling
bone marrow development
positive regulation of sequence-specific DNA binding transcription factor activity
anatomical structure regression
retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
bone morphogenesis
branching involved in mammary gland duct morphogenesis
adipose tissue development
cell-cell signaling involved in mammary gland development
regulation of canonical Wnt signaling pathway
regulation of insulin secretion involved in cellular response to glucose stimulus
retinal blood vessel morphogenesis
negative regulation of protein serine/threonine kinase activity
apoptotic process involved in patterning of blood vessels
beta-catenin destruction complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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