Proteintech

LRPPRC Polyclonal Antibody

View all (14) LRP130 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (19)

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 19

LRPPRC Antibody (21175-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed U2OS cells using (Product # 21175-1-AP) (LRPPRC antibody), at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). F-actin is stained using CL555-phalloidin (red) and DNA is stained by DAPI (blue).

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

LRPPRC Antibody in Immunocytochemistry (ICC/IF)

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Western Blot (WB)

LRPPRC Antibody in Immunoprecipitation (IP)

Product Image Gallery

LRPPRC Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of (4% PFA) fixed U2OS cells using (Product # 21175-1-AP) (LRPPRC antibody), at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). F-actin is stained using CL555-phalloidin (red) and DNA is stained by DAPI (blue).

LRPPRC Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of Hela cells, using LRPPRC antibody 21175-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

LRPPRC Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of 293 cells, using LRPPRC antibody 21175-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

LRPPRC Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HEK-293 cells using 21175-1-AP (LRPPRC antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

LRPPRC Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using LRPPRC antibody 21175-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney using 21175-1-AP (LRPPRC antibody) at dilution of 1:100 (under 40x lens).

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney using 21175-1-AP (LRPPRC antibody) at dilution of 1:100 (under 10x lens).

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human heart using 21175-1-AP (LRPPRC antibody) at dilution of 1:100 (under 40x lens).

LRPPRC Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human heart using 21175-1-AP (LRPPRC antibody) at dilution of 1:100 (under 10x lens).

LRPPRC Antibody in Western Blot (WB) — Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — Rat kidney tissue were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — Rat liver tissue were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with 21175-1-AP (LRPPRC antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours.

LRPPRC Antibody in Immunoprecipitation (IP) — IP result of anti-LRPPRC (IP:21175-1-AP, 5ug; Detection:21175-1-AP 1:1000) with HeLa cells lysate 1200ug.

Product Details

21175-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

-

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Not applicable (N/A)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LRPPRC Fusion Protein Ag15452 (1014-1394 aa encoded by BC050311)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LWYEDEKHS LNSSSASTTE PDFQKDILIA CRLNQKKGAY DIFLNAKEQN IVFNAETYSN LIKLLMSEDY FTQAMEVKAF AETHIKGFTL NDAANSRLII TQVRRDYLKE AVTTLKTVLD QQQTPSRLAV TRVIQALAMK GDVENIEVVQ KMLNGLEDSI GLSKMVFINN IALAQIKNNN IDAAIENIEN MLTSENKVIE PQYFGLAYLF RKVIEEQLEP AVEKISIMAE RLANQFAIYK PVTDFFLQLV DAGKVDDARA LLQRCGAIAE QTPILLLFLL RNSRKQGKAS TVKSVLELIP ELNEKEEAYN SLMKSYVSEK DVTSAKALYE HLTAKNTKLD DLFLKRYASL LKYAGEPVPF IEPPESFEFY AQQLRKLREN SS (1014-1394 aa encoded by B C050311)

Target Information

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo.

Phytotherapy research : PTR

Liang L,Sun W,Wei X,Wang L,Ruan H,Zhang J,Li S,Zhao B,Li M,Cai Z,Huang J

Tue Aug 01 00:00:00 UTC 2023

Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC.

Biochimica et biophysica acta. Molecular basis of disease

Zhao Z,Xu H,Wei Y,Sun L,Song Y

Wed Feb 01 00:00:00 UTC 2023

Localization of Mitochondrial Nucleoids by Transmission Electron Microscopy Using the Transgenic Expression of the Mitochondrial Helicase Twinkle and APEX2.

Methods in molecular biology (Clifton, N.J.)

Pla-Martín D,Babatz F,Schauss AC

Fri Feb 24 00:00:00 UTC 2023

A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC.

Autophagy

Guo X,Zhang Z,Lin C,Ren H,Li Y,Zhang Y,Qu Y,Li H,Ma S,Xia H,Sun R,Zu H,Lin Y,Wang X

Mon May 01 00:00:00 UTC 2023

A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC.

Autophagy

Guo X,Zhang Z,Lin C,Ren H,Li Y,Zhang Y,Qu Y,Li H,Ma S,Xia H,Sun R,Zu H,Lin Y,Wang X

Mon May 01 00:00:00 UTC 2023

Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA.

Methods in molecular biology (Clifton, N.J.)

Ng KY,Battersby BJ

Mon May 15 00:00:00 UTC 2023

Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival.

bioRxiv : the preprint server for biology

Ronayne CT,Bennett CF,Perry EA,Kantorovich N,Puigserver P

Tue Mar 21 00:00:00 UTC 2023

Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes.

Genome biology

Soto I,Couvillion M,Hansen KG,McShane E,Moran JC,Barrientos A,Churchman LS

Tue Aug 09 00:00:00 UTC 2022

Nonstop mRNAs generate a ground state of mitochondrial gene expression noise.

Science advances

Ng KY,Lutfullahoglu Bal G,Richter U,Safronov O,Paulin L,Dunn CD,Paavilainen VO,Richer J,Newman WG,Taylor RW,Battersby BJ

Wed Nov 16 00:00:00 UTC 2022

Methylation Pattern Mediated by m⁶A Regulator and Tumor Microenvironment Invasion in Lung Adenocarcinoma.

Oxidative medicine and cellular longevity

Jiang F,Hu Y,Liu X,Wang M,Wu C

Fri Mar 04 00:00:00 UTC 2022

CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model.

Proceedings of the National Academy of Sciences of the United States of America

Yu J,Liufu T,Zheng Y,Xu J,Meng L,Zhang W,Yuan Y,Hong D,Charlet-Berguerand N,Wang Z,Deng J

Tue Oct 11 00:00:00 UTC 2022

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.

Nature communications

Sen A,Kallabis S,Gaedke F,Jüngst C,Boix J,Nüchel J,Maliphol K,Hofmann J,Schauss AC,Krüger M,Wiesner RJ,Pla-Martín D

Mon Nov 07 00:00:00 UTC 2022

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.

Nature communications

Sen A,Kallabis S,Gaedke F,Jüngst C,Boix J,Nüchel J,Maliphol K,Hofmann J,Schauss AC,Krüger M,Wiesner RJ,Pla-Martín D

Mon Nov 07 00:00:00 UTC 2022

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.

Nature communications

Sen A,Kallabis S,Gaedke F,Jüngst C,Boix J,Nüchel J,Maliphol K,Hofmann J,Schauss AC,Krüger M,Wiesner RJ,Pla-Martín D

Mon Nov 07 00:00:00 UTC 2022

LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.

The FEBS journal

Xu Z,Li X,Ding Z,Zhang Y,Peng Z,Yang X,Cao W,Du R

Thu Dec 01 00:00:00 UTC 2022

LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.

The FEBS journal

Xu Z,Li X,Ding Z,Zhang Y,Peng Z,Yang X,Cao W,Du R

Thu Dec 01 00:00:00 UTC 2022

Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.

Frontiers in immunology

Jin Y,Wang Z,He D,Zhu Y,Hu X,Gong L,Xiao M,Chen X,Cheng Y,Cao K

Thu Sep 23 00:00:00 UTC 2021

Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation.

Frontiers in cell and developmental biology

Lu W,Che X,Qu X,Zheng C,Yang X,Bao B,Li Z,Wang D,Jin Y,Wang Y,Xiao J,Qi J,Liu Y

Wed Mar 10 00:00:00 UTC 2021

Succinylation Regulators Promote Clear Cell Renal Cell Carcinoma by Immune Regulation and RNA N6-Methyladenosine Methylation.

Frontiers in cell and developmental biology

Lu W,Che X,Qu X,Zheng C,Yang X,Bao B,Li Z,Wang D,Jin Y,Wang Y,Xiao J,Qi J,Liu Y

Wed Mar 10 00:00:00 UTC 2021

MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

He X,Zhu Y,Yang L,Wang Z,Wang Z,Feng J,Wen X,Cheng L,Zhu R

Sat May 01 00:00:00 UTC 2021

LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.

Redox biology

Wei WS,Wang N,Deng MH,Dong P,Liu JY,Xiang Z,Li XD,Li ZY,Liu ZH,Peng YL,Li Z,Jiang LJ,Yao K,Ye YL,Lu WH,Zhang ZL,Zhou FJ,Liu ZW,Xie D,Yu CP

Sat Nov 27 00:00:00 UTC 2021

LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.

Redox biology

Wei WS,Wang N,Deng MH,Dong P,Liu JY,Xiang Z,Li XD,Li ZY,Liu ZH,Peng YL,Li Z,Jiang LJ,Yao K,Ye YL,Lu WH,Zhang ZL,Zhou FJ,Liu ZW,Xie D,Yu CP

Sat Nov 27 00:00:00 UTC 2021

Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.

Clinical and translational medicine

Liu AD,Zhou J,Bi XY,Hou GQ,Li SS,Chen Q,Xu H,Cao X

Mon Mar 01 00:00:00 UTC 2021

A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.

Nature communications

Sun P,Nie K,Zhu Y,Liu Y,Wu P,Liu Z,Du S,Fan H,Chen CH,Zhang R,Wang P,Cheng G

Tue Jan 14 00:00:00 UTC 2020

A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.

Nature communications

Sun P,Nie K,Zhu Y,Liu Y,Wu P,Liu Z,Du S,Fan H,Chen CH,Zhang R,Wang P,Cheng G

Tue Jan 14 00:00:00 UTC 2020

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.

EMBO reports

Sun X,Thorne RF,Zhang XD,He M,Li J,Feng S,Liu X,Wu M

Fri Apr 03 00:00:00 UTC 2020

Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through modulation of the NF-κB and HIF-1α signaling pathways in mice.

Food & function

Huang Y,Qiu L,Mi X,Zhang Z,Xu D,Tao X,Xing K,Wu Q,Wei H

Thu Apr 30 00:00:00 UTC 2020

Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.

Colloids and surfaces. B, Biointerfaces

Zhu Y,Meng Y,Zhao Y,Zhu J,Xu H,Zhang E,Shi L,Du L,Liu G,Zhang C,Xu X,Kang X,Zhen Y,Zhang S

Mon Jul 01 00:00:00 UTC 2019

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Nature biotechnology

Liang XH,Shen W,Sun H,Migawa MT,Vickers TA,Crooke ST

Mon Aug 01 00:00:00 UTC 2016

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Nature biotechnology

Liang XH,Shen W,Sun H,Migawa MT,Vickers TA,Crooke ST

Mon Aug 01 00:00:00 UTC 2016

Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.

The EMBO journal

Ma Y,Yao N,Liu G,Dong L,Liu Y,Zhang M,Wang F,Wang B,Wei X,Dong H,Wang L,Ji S,Zhang J,Wang Y,Huang Y,Yu J

Tue Feb 03 00:00:00 UTC 2015

Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.

The EMBO journal

Ma Y,Yao N,Liu G,Dong L,Liu Y,Zhang M,Wang F,Wang B,Wei X,Dong H,Wang L,Ji S,Zhang J,Wang Y,Huang Y,Yu J

Tue Feb 03 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 130 kDa leucine-rich protein; GP130; Leucine rich protein 157; leucine rich protein LRP130; leucine-rich pentatricopeptide repeat containing; Leucine-rich PPR motif-containing protein, mitochondrial; leucine-rich PPR-motif containing; leucine-rich protein 157; LRP 130; mitochondrial leucine-rich PPR motif-containing protein; rLRP157

View more View less

Gene Aliases: 3110001K13Rik; C76645; CLONE-23970; GP130; LRP130; Lrp157; LRPPRC; LSFC

View more View less

UniProt ID: (Human) P42704, (Rat) Q5SGE0, (Mouse) Q6PB66

View more View less

Entrez Gene ID: (Human) 10128, (Rat) 313867, (Mouse) 72416

View more View less

single-stranded DNA binding RNA binding protein binding microtubule binding ubiquitin protein ligase binding poly(A) RNA binding beta-tubulin binding actin filament binding molecular_function DNA binding

negative regulation of mitochondrial RNA catabolic process transcription, DNA-templated regulation of transcription, DNA-templated mitochondrion transport along microtubule mRNA transport regulation of mitochondrial translation biological_process transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support