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Product Details
PA5-31928
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human LRRC23. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.78 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549401
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Human (99%), Mouse (84%), Rat (82%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The LRRC23 (Leucine-Rich Repeat Containing 23) gene encodes a protein that is an evolutionarily conserved component of the radial spoke complex in sperm flagella. It is located on human chromosome 12. The LRRC23 protein interacts with radial spoke head proteins such as RSPH3A and RSPH3B, crucial for the structural integrity and proper function of the radial spokes, which are essential for flagellar motility. Mutations or deficiencies in LRRC23 have been linked to male infertility, specifically causing asthenozoospermia, characterized by reduced sperm motility. Studies have identified various mutations in LRRC23 that result in disorganized radial spokes and impaired sperm motility, leading to infertility
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich protein B7; Leucine-rich repeat-containing protein 23
Gene Aliases: LRPB7; LRRC23
UniProt ID: (Human) Q53EV4
Entrez Gene ID: (Human) 10233
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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