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Product Details
PA5-111326
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human LRRC4. Recombinant protein control fragment (Product #RP-100944).
Conjugate
Form
Liquid
Concentration
0.40 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856736
Product Specific Information
Immunogen sequence: APSGVSGEGA VVLPTIHDHI NYNTYKPAHG AHWTENSLGN SLHPTVTTIS EPYIIQTHTK DKVQE
Target Information
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; leucine-rich repeat-containing 4; Leucine-rich repeat-containing protein 4; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2; NLG2
Gene Aliases: BAG; LRRC4; NAG14; NGL-2; UNQ554/PRO1111
UniProt ID: (Human) Q9HBW1
Entrez Gene ID: (Human) 64101
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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