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LRRC4 Antibody (PA5-47686) in IHC (P)
Immunohistochemical analysis of LRRC4 in immersion fixed paraffin-embedded sections of human brain (cerebellum). Samples were incubated in LRRC4 polyclonal antibody (Product # PA5-47686) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained with the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue).
Product Details
PA5-47686
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human LRRC4 Ala39-Lys527
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2577201
Product Specific Information
In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human LRRC3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; leucine-rich repeat-containing 4; Leucine-rich repeat-containing protein 4; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2; NLG2
Gene Aliases: BAG; LRRC4; NAG14; NGL-2; UNQ554/PRO1111
UniProt ID: (Human) Q9HBW1
Entrez Gene ID: (Human) 64101
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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