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Invitrogen
LRRC8A Polyclonal Antibody
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Product Details
PA5-72870
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LRRC8A antibody for a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is within amino acids 60 - 110 of LRRC8A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718724
Target Information
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ebo; HsLRRC8A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat containing 8 family member A; leucine-rich repeat-containing 8; Leucine-rich repeat-containing protein 8A; Protein ebouriffe; Swelling protein 1; Swelling protein 1 SWELL1; Volume-regulated anion channel subunit LRRC8A
Gene Aliases: AGM5; KIAA1437; LRRC8; LRRC8A; mKIAA1437; SWELL1; UNQ221/PRO247
UniProt ID: (Human) Q8IWT6, (Mouse) Q80WG5, (Rat) Q4V8I7
Entrez Gene ID: (Human) 56262, (Mouse) 241296, (Rat) 311846
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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