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LRRTM2 (extracellular) Antibody (ANR-142-200UL) in IHC (F)
Expression of LRRTM2 in mouse parietal cortex. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-LRRTM2 (extracellular) Antibody (#ANR-142), (1:400), followed by goat Anti-rabbit-AlexaFluor-488. A. LRRTM2 immunoreactivity (green) appears in cortical neurons in layer 5 (arrows). B. Pre-incubation of the Antibody with LRRTM2 (extracellular) Blocking Peptide (BLP-NR142), sup... View More
Product Details
ANR-142-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide CDSQGFHSVPNATDK, corresponding to amino acid residues 47-61 of mouse LRRTM2, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat neuronal 2 protein; leucine-rich repeat transmembrane neuronal 2 protein; Leucine-rich repeat transmembrane neuronal protein 2
Gene Aliases: AI851755; BB129880; C630011A14Rik; KIAA0416; LRRN2; LRRTM2; mKIAA0416
UniProt ID: (Human) O43300, (Mouse) Q8BGA3, (Rat) D4A7P2
Entrez Gene ID: (Human) 26045, (Mouse) 107065, (Rat) 685472
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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