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Invitrogen
LRWD1 Polyclonal Antibody
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Product Details
PA5-54380
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LRWD1. Recombinant protein control fragment (Product #RP-92783).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2643576
Product Specific Information
Immunogen sequence: PFLTVNDNLK VSFLLPTLRK VNGKDASSTY SQVENLNREL TSRVTAHWEK FMATLGPEEE AEKAQADFVK SAVRD
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 77%.
Target Information
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CENP-33; Centromere protein 33; Leucine-rich repeat and WD repeat-containing protein 1; leucine-rich repeats and WD repeat domain containing 1; ORC-associated protein; Origin recognition complex-associated protein; testicular tissue protein Li 4
Gene Aliases: CENP-33; LRWD1; ORCA
UniProt ID: (Human) Q9UFC0
Entrez Gene ID: (Human) 222229
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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