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LSR Antibody (A304-471A) in IP
Detection of human LSR by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using RIPA lysis buffer. Antibodies: Affinity purified rabbit anti-LSR antibody (Product # A304-471A) (lot 1) used for IP at 6 µg per reaction. LSR was also immunoprecipitated by rabbit anti-LSR antibody A304-470A. For blotting immunoprecipitated LSR, A304-471A was used at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-471A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 543 to 593 of human Lipolysis Stimulated Lipoprotein Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Lipolysis-stimulated lipoprotein receptor (LSR), encoded by the LSR gene, is a crucial component in lipid metabolism, particularly involved in the endocytosis of triglyceride-rich lipoproteins. It is typically expressed in liver and adipose tissues, playing a pivotal role in maintaining lipid and glucose homeostasis. LSR binds to lipoproteins in the presence of free fatty acids, facilitating the uptake and clearance of lipids from the bloodstream, which is significant in preventing atherosclerosis and other lipid-related disorders. The protein functions as a multi-subunit complex, which includes two isoforms, LSRa and LSRß, each contributing to lipoprotein metabolism. Research has highlighted its involvement in metabolic processes and its potential impacts on obesity and insulin resistance. LSR has also been studied in the context of hepatic lipid accumulation, where its downregulation is associated with increased lipid deposition in the liver, suggesting its importance in preventing non-alcoholic fatty liver disease (NAFLD). Due to its central role in lipid metabolism, LSR has emerged as a potential therapeutic target for metabolic diseases and cardiovascular conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angulin-1; immunoglobulin-like domain containing receptor 3; Lipolysis-stimulated lipoprotein receptor; lipolysis-stimulated remnant; LISCH protein; liver-specific bHLH-Zip transcription factor
Gene Aliases: ILDR3; LISCH; LISCH7; LSR
UniProt ID: (Human) Q8NBM0
Entrez Gene ID: (Human) 51599
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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