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Product Details
H00051599-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LSR (NP_991403, 1 a.a. approximately 649 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MQQDGLGVGT RNGSGKGRSV HPSWPWCAPR PLRYFGRDAR ARRAQTAAMA LLAGGLSRGL GSHPAAAGRD AVVFVWLLLS TWCTAPARAI QVTVSNPYHV VILFQPVTLP CTYQMTSTPT QPIVIWKYKS FCRDRIADAF SPASVDNQLN AQLAAGNPGY NPYVECQDSV RTVRVVATKQ GNAVTLGDYY QGRRITITGN ADLTFDQTAW GDSGVYYCSV VSAQDLQGNN EAYAELIVLG RTSGVAELLP GFQAGPIEDW LFVVVVCLAA FLIFLLLGIC WCQCCPHTCC CYVRCPCCPD KCCCPEALYA AGKAATSGVP SIYAPSTYAH LSPAKTPPPP AMIPMGPAYN GYPGGYPGDV DRSSSAGGQG SYVPLLRDTD SSVASEVRSG YRIQASQQDD SMRVLYYMEK ELANFDPSRP GPPSGRVERA MSEVTSLHED DWRSRPSRGP ALTPIRDEEW GGHSPRSPRG WDQEPAREQA GGGWRARRPR ARSVDALDDL TPPSTAESGS RSPTSNGGRS RAYMPPRSRS RDDLYDQDDS RDFPRSRDPH YDDFRSRERP PADPRSHHHR TRDPRDNGSR SGDLPYDGRL LEEAVRKKGS EERRRPHKEE EEEAYYPPAP PPYSETDSQA SRERRLKKNL ALSRESLVV
Target Information
Lipolysis-stimulated lipoprotein receptor (LSR), encoded by the LSR gene, is a crucial component in lipid metabolism, particularly involved in the endocytosis of triglyceride-rich lipoproteins. It is typically expressed in liver and adipose tissues, playing a pivotal role in maintaining lipid and glucose homeostasis. LSR binds to lipoproteins in the presence of free fatty acids, facilitating the uptake and clearance of lipids from the bloodstream, which is significant in preventing atherosclerosis and other lipid-related disorders. The protein functions as a multi-subunit complex, which includes two isoforms, LSRa and LSRß, each contributing to lipoprotein metabolism. Research has highlighted its involvement in metabolic processes and its potential impacts on obesity and insulin resistance. LSR has also been studied in the context of hepatic lipid accumulation, where its downregulation is associated with increased lipid deposition in the liver, suggesting its importance in preventing non-alcoholic fatty liver disease (NAFLD). Due to its central role in lipid metabolism, LSR has emerged as a potential therapeutic target for metabolic diseases and cardiovascular conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angulin-1; immunoglobulin-like domain containing receptor 3; Lipolysis-stimulated lipoprotein receptor; lipolysis-stimulated remnant; LISCH protein; liver-specific bHLH-Zip transcription factor
Gene Aliases: ILDR3; LISCH; LISCH7; LSR
UniProt ID: (Human) Q8NBM0
Entrez Gene ID: (Human) 51599
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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