Invitrogen

LXR alpha Recombinant Rabbit Monoclonal Antibody (12H21L12)

View all (21) LXR alpha antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

703430

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

12H21L12

Immunogen

Peptides corresponding to human LXR alpha [1) aa71-aa88 2) aa317-aa330 3) aa177-aa195]
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2811732

Product Specific Information

This antibody is predicted to react with Rat, Bovine.

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR alpha; LXRb; NER; NERI; NR1H2; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; ubiquitously-expressed nuclear receptor 1

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Gene Aliases: AU018371; LXR; LXR-a; LXRA; NR1H3; RLD-1; RLD1; Unr1

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UniProt ID: (Human) Q13133, (Mouse) Q9Z0Y9

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Entrez Gene ID: (Human) 10062, (Mouse) 22259

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Function(s)
DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding cholesterol binding sterol response element binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding metal ion binding retinoid X receptor binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter fatty acid biosynthetic process positive regulation of triglyceride biosynthetic process positive regulation of receptor biosynthetic process positive regulation of cholesterol efflux negative regulation of cholesterol storage intracellular receptor signaling pathway positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone positive regulation of toll-like receptor 4 signaling pathway cholesterol homeostasis negative regulation of macrophage activation apoptotic cell clearance steroid hormone mediated signaling pathway cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of pinocytosis negative regulation of inflammatory response positive regulation of lipoprotein lipase activity lipid homeostasis sterol homeostasis triglyceride homeostasis cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes regulation of cholesterol homeostasis positive regulation of cholesterol homeostasis transcription initiation from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation regulation of circadian rhythm negative regulation of interferon-gamma-mediated signaling pathway
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