Invitrogen

LXR beta Polyclonal Antibody

View all (18) LXR beta antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-20886

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 14 amino acid peptide from near the amino terminus human LXR-B.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11154066

Product Specific Information

A suggested positive control is human lung tissue lysate.

PA5-20886 can be used with blocking peptide PEP-1000.

Target Information

The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; LXR beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; steroid hormone-nuclear receptor NER; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2; UR

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Gene Aliases: AI194859; LXR; LXR-b; LXRB; LXRbeta; NER; NER-I; NER1; NR1H2; OR-1; RIP15; UNR; Unr2; UR

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UniProt ID: (Human) P55055, (Mouse) Q60644, (Rat) Q62755

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Entrez Gene ID: (Human) 7376, (Mouse) 22260, (Rat) 58851

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding apolipoprotein A-I receptor binding retinoid X receptor binding ATPase binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of lipid storage negative regulation of cholesterol storage positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport cholesterol homeostasis steroid hormone mediated signaling pathway cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway negative regulation of pinocytosis positive regulation of lipoprotein lipase activity negative regulation of interferon-gamma-mediated signaling pathway positive regulation of high-density lipoprotein particle assembly positive regulation of pancreatic juice secretion positive regulation of secretion of lysosomal enzymes regulation of cholesterol homeostasis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of gene expression negative regulation of gene expression intracellular receptor signaling pathway lipid homeostasis
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