Invitrogen

LXR beta Recombinant Superclonal™ Antibody (8 HCLC)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

711097

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

8 HCLC

Immunogen

Peptides corresponding to Human NR1H2 (aa 244-257, 57-74)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633121

Product Specific Information

This antibody is predicted to react with Monkey, Cat and Bat

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; LXR beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2

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Gene Aliases: AI194859; LXR; LXR-b; LXRB; LXRbeta; NER; NER-I; NER1; NR1H2; OR-1; RIP15; UNR; Unr2; UR

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UniProt ID: (Human) P55055, (Mouse) Q60644

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Entrez Gene ID: (Human) 7376, (Mouse) 22260

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding apolipoprotein A-I receptor binding retinoid X receptor binding ATPase binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of lipid storage negative regulation of cholesterol storage positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport cholesterol homeostasis steroid hormone mediated signaling pathway cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway negative regulation of pinocytosis positive regulation of lipoprotein lipase activity negative regulation of interferon-gamma-mediated signaling pathway positive regulation of high-density lipoprotein particle assembly positive regulation of pancreatic juice secretion positive regulation of secretion of lysosomal enzymes regulation of cholesterol homeostasis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of gene expression negative regulation of gene expression intracellular receptor signaling pathway lipid homeostasis
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