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Product Details
24433-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LYAR Fusion Protein Ag19599 (6-357 aa encoded by BC015796)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CNACGESVK KIQVEKHVSV CRNCECLSCI DCGKDFWGDD YKNHVKCISE DQKYGGKGYE GKTHKGDIKQ QAWIQKISEL IKRPNVSPKV RELLEQISAF DNVPRKKAKF QNWMKNSLKV HNESILDQVW NIFSEASNSE PVNKEQDQRP LHPVANPHAE ISTKVPASKV KDAVEQQGEV KKNKRERKEE RQKKRKREKK ELKLENHQEN SRNQKPKKRK KGQEADLEAG GEEVPEANGS AGKRSKKKKQ RKDSASEEEA RVGAGKRKRR HSEVETDSKK KKMKLPEHPE GGEPEDDEAP AKGKFNWKGT IKAILKQAPD NEITIKKLRK KVLAQYYTVT DEHHRSEEEL LVI (6-357 aa encoded by BC015796)
Target Information
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cell growth-regulating nucleolar protein; Ly1 antibody reactive homolog; Ly1 antibody-reactive protein; MLZ-264; Protein expressed in male leptotene and zygotene spermatocytes 264
Gene Aliases: LYAR; MLZ-264; PNAS-5; ZC2HC2; ZLYAR
UniProt ID: (Human) Q9NX58, (Mouse) Q08288
Entrez Gene ID: (Human) 55646, (Mouse) 17089
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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