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LYK5 Antibody (BS-3949R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse testis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with LYK5 Polyclonal Antibody, Unconjugated (bs-3949R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-3949R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human LYK5, amino acids 1-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
Gene Aliases: 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA
UniProt ID: (Human) Q7RTN6, (Rat) Q7TNZ6, (Mouse) Q3UUJ4
Entrez Gene ID: (Human) 92335, (Rat) 303605, (Mouse) 72149
protein kinase activity
protein binding
ATP binding
kinase binding
protein kinase activator activity
protein serine/threonine kinase activator activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
protein export from nucleus
cell cycle arrest
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
mitotic cell cycle
intracellular signal transduction
protein heterooligomerization
cell cycle
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
regulation of apoptotic process
regulation of MAPK cascade
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