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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Lyn Antibodies

          Proteintech

          LYN Polyclonal Antibody

          1 Reference
          View all (42) Lyn antibodies

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          Datasheet
          Protocols
          Questions & Answers
          Datasheet
          Protocols
          Questions & Answers

          Cite LYN Polyclonal Antibody

          • Antibody Testing Data (12)
          LYN Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          LYN Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 12

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          LYN Antibody (18135-1-AP) in ICC/IF

          Immunofluorescent analysis of HeLa cells using 18135-1-AP (LYN antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          LYN Antibody in Immunocytochemistry (ICC/IF)
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Flow Cytometry (Flow)
          LYN Antibody in Immunoprecipitation (IP)

          Product Details

          18135-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:20-1:200
          -

          Flow Cytometry (Flow)

          0.2 µg/1x10^6 cells
          -

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          LYN Fusion Protein Ag12723 (132-512 aa encoded by BC075002)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.39 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: KDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP (132-512 aa encoded by BC075002)

          Target Information

          Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: FLJ26625; Lck/Yes-related novel protein tyrosine kinase; p53Lyn; p56Lyn; Tyrosine-protein kinase Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

          View more View less

          Gene Aliases: JTK8; LYN; p53Lyn; p56Lyn

          View more View less

          UniProt ID: (Human) P07948

          View more View less

          Entrez Gene ID: (Human) 4067

          View more View less

          Function(s)
          protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding protein binding ATP binding SH3 domain binding ubiquitin protein ligase binding gamma-tubulin binding glycosphingolipid binding ion channel binding phosphoprotein binding
          Process(es)
          B cell homeostasis regulation of cytokine production regulation of protein phosphorylation negative regulation of protein phosphorylation stimulatory C-type lectin receptor signaling pathway adaptive immune response Fc receptor mediated stimulatory signaling pathway tolerance induction to self antigen histamine secretion by mast cell platelet degranulation negative regulation of myeloid leukocyte differentiation immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway regulation of B cell apoptotic process protein phosphorylation inflammatory response cellular response to DNA damage stimulus response to sterol depletion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway central nervous system development blood coagulation positive regulation of cell proliferation negative regulation of cell proliferation response to toxic substance response to hormone response to carbohydrate positive regulation of neuron projection development oligodendrocyte development response to organic cyclic compound viral process peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation platelet activation erythrocyte differentiation positive regulation of cell migration negative regulation of B cell proliferation neuron projection development T cell costimulation lipopolysaccharide-mediated signaling pathway cellular response to extracellular stimulus response to insulin regulation of mast cell activation regulation of cell adhesion mediated by integrin negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway cellular response to heat peptidyl-tyrosine autophosphorylation Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis response to drug positive regulation of tyrosine phosphorylation of STAT protein response to amino acid regulation of mast cell degranulation negative regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of erythrocyte differentiation protein autophosphorylation ephrin receptor signaling pathway response to axon injury cytokine secretion regulation of cytokine secretion regulation of inflammatory response negative regulation of immune response B cell receptor signaling pathway regulation of B cell receptor signaling pathway positive regulation of B cell receptor signaling pathway leukocyte migration positive regulation of cellular component movement regulation of release of sequestered calcium ion into cytosol positive regulation of glial cell proliferation positive regulation of Fc receptor mediated stimulatory signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway positive regulation of stress-activated protein kinase signaling cascade regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation negative regulation of mast cell proliferation positive regulation of mast cell proliferation cellular response to retinoic acid regulation of monocyte chemotaxis regulation of platelet aggregation dendritic cell differentiation negative regulation of intracellular signal transduction positive regulation of dendritic cell apoptotic process
          It has to be done as per old AB suggested Products section.
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