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Invitrogen
LZTFL1 Polyclonal Antibody
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Product Details
PA5-21573
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human LZTFL1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153281
Product Specific Information
Recommended positive controls: NT2D1, IMR32, Jurkat, HeLa, mouse testis, rat testis.
Predicted reactivity: Mouse (88%), Rat (90%), Rhesus Monkey (98%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
LZTFL1, also known as Leucine Zipper Transcription Factor-Like 1, is situated on the chromosomal region 3p21.3, which is frequently deleted in various cancers, including kidney cancer. It acts as a tumor suppressor by destabilizing AKT, a key protein in cell growth pathways, thus inhibiting tumor cell growth. Additionally, LZTFL1 has been implicated in the epithelial-mesenchymal transition in COVID-19, suggesting a role in viral response pathways. It is associated with Bardet-Biedl syndrome (BBS) and interacts with IFT27, a regulator of sperm flagellum formation, affecting spermatogenesis and male fertility. Knockout models show a phenotype of obesity, retinal degeneration, and abnormal cilia development, highlighting its role in normal ciliary function. The gene has two transcript isoforms and is part of a transcriptional map covering 250 kb, making it a subject of extensive genetic research.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leucine zipper transcription factor-like 1; Leucine zipper transcription factor-like protein 1
Gene Aliases: 5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; LZTFL1
UniProt ID: (Human) Q9NQ48, (Mouse) Q9JHQ5, (Rat) Q562C6
Entrez Gene ID: (Human) 54585, (Mouse) 93730, (Rat) 316102
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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