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Invitrogen
Lactoferrin Recombinant Rabbit Monoclonal Antibody (002)
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Product Details
MA5-29743
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
002
Immunogen
Recombinant Mouse Lactotransferrin/LTF protein (Met1-Gln707)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785566
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse Lactotransferrin/LTF.
Target Information
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKRX; Kaliocin 1; Kaliocin1; Lactoferricin H; Lactoferrin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; minisatellite 10r detected by probe MMS10; N lobe
Gene Aliases: Csp82; Lf; Ltf; MMS10R; Ms10r
UniProt ID: (Mouse) P08071
Entrez Gene ID: (Mouse) 17002
ossification
regulation of cytokine production
innate immune response in mucosa
immune system process
proteolysis
transport
ion transport
antibacterial humoral response
antifungal humoral response
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor production
negative regulation of ATPase activity
positive regulation of osteoblast proliferation
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation by host of viral process
negative regulation of viral genome replication
positive regulation of osteoblast differentiation
negative regulation of viral process
positive regulation of NF-kappaB transcription factor activity
iron ion homeostasis
bone morphogenesis
positive regulation of protein serine/threonine kinase activity
negative regulation of single-species biofilm formation in or on host organism
positive regulation of chondrocyte proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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