Invitrogen

Lactoferrin Monoclonal Antibody (KT12)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-49594

Applications
Tested Dilution
Publications

ELISA (ELISA)

1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

KT12

Immunogen

Purified Human Lactoferrin
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3090650

Product Specific Information

This product was used in both Indirect and Sandwich ELISA.

Target Information

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; neutrophil lactoferrin; Talalactoferrin

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Gene Aliases: GIG12; HEL110; HLF2; LF; LTF

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UniProt ID: (Human) P02788

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Entrez Gene ID: (Human) 4057

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Function(s)
DNA binding serine-type endopeptidase activity iron ion binding protein binding heparin binding protein serine/threonine kinase activator activity
Process(es)
ossification regulation of cytokine production retina homeostasis innate immune response in mucosa transcription, DNA-templated proteolysis ion transport humoral immune response antibacterial humoral response antifungal humoral response negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity iron assimilation by chelation and transport positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling cellular protein metabolic process negative regulation by host of viral process negative regulation of viral genome replication cell redox homeostasis positive regulation of osteoblast differentiation negative regulation of viral process positive regulation of NF-kappaB transcription factor activity bone morphogenesis positive regulation of protein serine/threonine kinase activity positive regulation of bone mineralization involved in bone maturation negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development
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