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Progen
Lamin A/C Monoclonal Antibody (R27)
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Product Details
651138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Fish,
Human,
Mouse,
Xenopus,
Zebrafish
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
R27
Immunogen
Nuclear Pore Complex-Lamina Fraction Of Bovine Liver
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Recognizes the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope.
Target Information
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa lamin; Lamin A+C mutant; lamin a-c; lamin A/C-like 1; Lamin AC; lamin C; Lamin-A; lamin-A/C; mutant 453W; Mutant lamin A/C; nuclear intermediate filament protein; Prelamin-A/C; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1
Gene Aliases: BOS_2775; cb948; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; lmna-A; LMNC; LMNL1; PRO1; wu:fk66d12; XELAEV_18040808mg
UniProt ID: (Human) P02545, (Mouse) P48678, (Xenopus) P11048
Entrez Gene ID: (Bovine) 404144, (Human) 4000, (Mouse) 16905, (Zebrafish) 195815, (Xenopus) 373673
nucleus organization
nuclear envelope organization
muscle organ development
establishment of cell polarity
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
protein localization to nucleus
sterol regulatory element binding protein import into nucleus
ventricular cardiac muscle cell development
negative regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway
heart contraction
regulation of cell aging
mitotic nuclear envelope disassembly
mitotic nuclear envelope reassembly
spermatogenesis
response to mechanical stimulus
IRE1-mediated unfolded protein response
positive regulation of osteoblast differentiation
cellular response to hypoxia
negative regulation of adipose tissue development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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