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Invitrogen
Lamin B Receptor Polyclonal Antibody
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FIGURE: 1 / 3
Lamin B Receptor Antibody (PA5-102777) in ICC/IF
Immunocytochemistry analysis of Lamin B Receptor in A549 cells (UV treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Lamin B Receptor polyclonal antibody (Product # PA5-102777) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an Al... View More
Product Details
PA5-102777
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LBR(Accession Q14739), corresponding to amino acid residues A332-D382.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852168
Product Specific Information
Antibody detects endogenous levels of total LBR.
Target Information
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta(14)-sterol reductase LBR; Delta-14-SR; FLJ43126; ichthyosis; Integral nuclear envelope inner membrane protein; Lamin-B receptor; LMN2R; MGC9041; PRO0650; Sterol C14-reductase; tudor domain containing 18
Gene Aliases: AI505894; DHCR14B; ic; LBR; LMN2R; PHA; TDRD18
UniProt ID: (Human) Q14739, (Mouse) Q3U9G9
Entrez Gene ID: (Human) 3930, (Mouse) 98386
DNA binding
protein binding
lamin binding
oxidoreductase activity, acting on the CH-CH group of donors
poly(A) RNA binding
delta14-sterol reductase activity
chromo shadow domain binding
nuclear localization sequence binding
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
chaperone binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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