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Invitrogen
Lefty1/Lefty2 Recombinant Rabbit Monoclonal Antibody (23GB6650)
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FIGURE: 1 / 1
Lefty1/Lefty2 Antibody (MA5-53088) in WB
Western Blot analysis of Lefty1/Lefty2. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Lefty1/Lefty2 recombinant monoclonal antibody (Product # MA5-53088) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Product Details
MA5-53088
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB6650
Immunogen
A synthesized peptide derived from human LEFTY1+LEFTY2 (330-366AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3249563
Target Information
Left-right determination factor 1 and 2 (Lefty1/2) belong to the TGF-beta superfamily of proteins and are responsible for determination of left-right positioning of visceral organs during embryogenesis. Lefty1 acts as a regulator of Lefty2 and NODAL as the lack of the former resulted in bilateral expression of nodal, lefty2 and Pitx2 (a homeobox gene normally expressed on the left side and blocks the signal for leftness). Lefty2 may play a role in endometrial bleeding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left-right determination factor 1; Left-right determination factor 2; Left-right determination factor A; Left-right determination factor B; left-right determination, factor A; left-right determination, factor B; Lefty protein; Protein lefty-1; Protein lefty-2; Protein lefty-A; Protein lefty-B; Stimulated by retinoic acid gene 3 protein; TGF-beta-4; Transforming growth factor beta-4
Gene Aliases: 6030463A22Rik; AI450052; AV214969; EBAF; Ebaf2; LEFTA; LEFTB; Lefty; lefty-1; LEFTY1; LEFTY2; LEFTYA; LEFTYB; PSEC0024; RGD1561867; Stra3; TGFB4; UNQ278/PRO317
UniProt ID: (Human) O75610, (Human) O00292, (Mouse) Q64280, (Mouse) P57785
Entrez Gene ID: (Human) 10637, (Human) 7044, (Rat) 498299, (Mouse) 13590, (Rat) 289316, (Mouse) 320202
platelet degranulation
transforming growth factor beta receptor signaling pathway
multicellular organism development
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
determination of left/right symmetry
negative regulation of cell proliferation
anterior/posterior axis specification
response to retinoic acid
cell migration involved in gastrulation
negative regulation of nodal signaling pathway
negative regulation of nodal receptor complex assembly
growth
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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