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Invitrogen
Levo-alpha-Acetylmethadol Polyclonal Antibody
Product Details
PA1-75235
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LAAM(p)-BSA
Conjugate
Form
Liquid
Purification
purified
Storage buffer
PBS, pH 7.3
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1090386
Product Specific Information
Working Concentration: 1/32K. Sensitivity: 10 ng/mL LAAM produces 80% inhibition in a competitive ELISA employing LevoAlphaAcetylmethadol (LAAM) polyclonal antibody.
Target Information
Levomethadyl Acetate is only found in individuals that have used or taken this drug. It is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]Opiate receptors (Mu, Kappa, Delta) are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Levomethadyl acetate effectively opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist), resulting in hyperpolarization and reduced neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=15130].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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