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Invitrogen
Lewis A/B Chimeric Recombinant Rabbit Monoclonal Antibody (HEA164)
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FIGURE: 1 / 2
Lewis A/B Chimeric Antibody (MA5-48240) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of Lewis A/B in Caco-2 cells using Lewis A/B Chimeric Monoclonal Antibody (Product # MA5-48240). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with Lewis A/B Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining. The nuclear stain is DAPI (blue). Panels sho... View More
Product Details
MA5-48240
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HEA164
Immunogen
This antibody was raised by immunising mice with human carcinoma cells.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074682
Product Specific Information
Specificity: This antibody is specific for Lewis a,b carbohydrate antigens.
Target Information
Lewis A and Lewis B are fucose-containing carbohydrates that are expressed on the surface of red blood cells and other tissues in the body. These carbohydrates are part of the larger family of molecules known as Lewis antigens, which play a role in a variety of biological processes, including immune recognition, cell adhesion, and inflammation. The expression of Lewis A and B on red blood cells is determined by the FUT3 gene, which encodes for the fucosyltransferase enzyme that adds the fucose sugar to precursor molecules. In general, individuals with the FUT3 gene mutation that leads to the expression of Lewis A antigen are unable to produce the Lewis B antigen, and vice versa. However, some individuals may be ""Lewis negative,"" meaning that they do not express either antigen due to mutations in the FUT2 gene. The presence or absence of Lewis antigens can also have implications for disease susceptibility and treatment, particularly in the context of cancer and other inflammatory conditions, as they can modulate immune responses and promote tumor growth and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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