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LexA DNA-binding Domain Polyclonal Antibody
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LexA DNA-binding Domain Antibody (39184) in WB
LexA DNA-binding Domain pAb tested by Western blot. 20 µg of crude yeast protein extracts probed with LexA DNA-binding Domain pAb (1:100,000 dilution). Lane 1: Extract from wild-type yeast. Lane 2: Extract from yeast expressing a LexA-Retinoblastoma (Rb) fusion protein.
Product Details
39184
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Yeast
Published species
Yeast
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This LexA DNA-binding Domain antibody was raised against recombinant protein corresponding to full-length E. coli LexA.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2793174
Target Information
E. coli LexA protein inhibits the transcription of the genes belonging to the SOS regulon that are related to DNA repair and cell division by recognizing and binding to the SOS-box sequence. LexA‘s self-protease activity is promoted by RecA protein which, responding to DNA damage, is activated by its binding to single-strand DNA accumulated in the cells. It is cleaved into two fragments and loses its function as a repressor. As the result, the expression of genes belonging to the SOS regulon is induced, and mutagenic activity in the cells are enhanced.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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