Proteintech

Lin28A Polyclonal Antibody

Lin28A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 18

Lin28A Antibody (16177-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human small intestine using 16177-1-AP (Lin28A-specific antibody) at dilution of 1:50 (under 40x lens).

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Product Details

16177-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human LIN28.This antibody recognize Lin28A specifically.

Target Information

Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LncRNA DDX11-AS1 Promotes Chemoresistance through LIN28A-Mediated ATG12 mRNA Stabilization in Breast Cancer.

Pharmacology

Si X,Zhang G,Li M,Yao M,Shi X,Dong Z,Gao S

Fri Jan 06 00:00:00 UTC 2023

LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming.

Cell death and differentiation

Pieknell K,Sulistio YA,Wulansari N,Darsono WHW,Chang MY,Ko JY,Chang JW,Kim MJ,Lee MR,Lee SA,Lee H,Lee G,Jung BH,Park H,Kim GH,Kim D,Cho G,Kim CH,Ly DD,Park KS,Lee SH

Tue Mar 01 00:00:00 UTC 2022

The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse.

EMBO reports

Wang W,Su L,Ji F,Zhang D,Wang Y,Zhao J,Jiao RD,Zhang M,Huang E,Jiang H,Zhang J,Jiao J

Thu Feb 03 00:00:00 UTC 2022

Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate.

Annals of the New York Academy of Sciences

Jia S,Zhang Q,Wang Y,Wei X,Gu H,Liu D,Ma W,He Y,Luo W,Yuan Z

Sat Oct 01 00:00:00 UTC 2022

Lin 28A/Occludin axis: An aberrantly activated pathway in intestinal epithelial cells leading to impaired barrier function under total parenteral nutrition.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology