NeoBiotechnologies

Liver X Receptor beta (LXRB) (Orphan Receptor) Monoclonal Antibody (LXRB/2731)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

7376-MSM1-P0

Applications
Tested Dilution
Publications

ELISA (ELISA)

Assay-dependent
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2c, kappa

Class

Monoclonal

Type

Antibody

Clone

LXRB/2731

Immunogen

Recombinant full-length human NR1H2 (LXRB) protein
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Wet ice

Target Information

The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor

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Gene Aliases: LXR-b; LXRB; NER; NER-I; NR1H2; RIP15; UNR

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UniProt ID: (Human) P55055

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Entrez Gene ID: (Human) 7376

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding apolipoprotein A-I receptor binding retinoid X receptor binding ATPase binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux positive regulation of lipid storage negative regulation of cholesterol storage positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport cholesterol homeostasis steroid hormone mediated signaling pathway cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway negative regulation of pinocytosis positive regulation of lipoprotein lipase activity negative regulation of interferon-gamma-mediated signaling pathway positive regulation of high-density lipoprotein particle assembly positive regulation of pancreatic juice secretion positive regulation of secretion of lysosomal enzymes regulation of cholesterol homeostasis
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