Product References
Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions.
Frontiers in immunology
Rizvi ZA,Babele P,Madan U,Sadhu S,Tripathy MR,Goswami S,Mani S,Dikshit M,Awasthi A
14-5931-82 was used in In vitro Assay to demonstrate a robust protective effect of WS against COVID-19 through its broader immunomodulatory activity.
Mon Mar 27 00:00:00 UTC 2023
Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment.
NPJ Regenerative medicine
Wang RM,Mesfin JM,Karkanitsa M,Ungerleider JL,Zelus E,Zhang Y,Kawakami Y,Kawakami Y,Kawakami T,Christman KL
14-5931-82 was used in Immunohistochemistry to investigate the role of mast cells in the regulation of the immune response to decellularized biomaterial scaffolds using a subcutaneous implant model.
Wed Sep 20 00:00:00 UTC 2023
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice.
Molecular neurodegeneration
Taylor X,Clark IM,Fitzgerald GJ,Oluoch H,Hole JT,DeMattos RB,Wang Y,Pan F
14-5931-82 was used in Immunohistochemistry to establish a connection between Aβ antibodies engaged at cerebral amyloid angiopathy deposits, the activation of perivascular macrophages, and the upregulation of genes involved in vascular permeability.
Wed Aug 30 00:00:00 UTC 2023
Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid 2-related factor 2 degradation.
International journal of biological sciences
Zhu H,Dai Z,Liu X,Zhou H,Wang Y
14-5931-82 was used in Immunohistochemistry-immunofluorescence to suggest that STK3 upregulation contributes to septic cardiomyopathy by phosphorylating KEAP1 to promote Nrf2 degradation and suppression of the antioxidant response.
Tue Apr 18 00:00:00 UTC 2023
Macrophage PTEN controls STING-induced inflammation and necroptosis through NICD/NRF2 signaling in APAP-induced liver injury.
Cell communication and signaling : CCS
Yang T,Qu X,Zhao J,Wang X,Wang Q,Dai J,Zhu C,Li J,Jiang L
14-5931-82 was used in Immunohistochemistry to demonstrate that the macrophage PTEN-NICD/NRF2-STING axis is critical to regulating oxidative stress-induced liver inflammation and necroptosis in AILI and implies the therapeutic potential for managing sterile liver inflammation.
Tue Jun 27 00:00:00 UTC 2023
Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.
Journal of experimental & clinical cancer research : CR
Zheng Y,Wang N,Wang S,Zhang J,Yang B,Wang Z
14-5931-82 was used in Immunohistochemistry-immunofluorescence to investigate the impact of chronic psychological stress on breast cancer growth, metastasis, and pre-metastatic niche (PMN) formation.
Sat May 20 00:00:00 UTC 2023
Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice.
Molecular therapy : the journal of the American Society of Gene Therapy
Yang MS,Park MJ,Lee J,Oh B,Kang KW,Kim Y,Lee SM,Lim JO,Jung TY,Park JH,Park SC,Lim YS,Hwang SB,Lyoo KS,Kim DI,Kim B
14-5931-82 was used in Immunohistochemistry to study diverse pulmonary diseases.
Wed May 04 00:00:00 UTC 2022
Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome.
Basic research in cardiology
Selejan SR,Linz D,Mauz M,Hohl M,Huynh AKD,Speer T,Wintrich J,Kazakov A,Werner C,Mahfoud F,Böhm M
14-5931-82 was used in Immunohistochemistry to investigate the effect of sympathetic modulation by renal denervation (RDN) on atrial remodeling, RAGE/sRAGE and RAGE ligands in metabolic syndrome.
Thu Jul 14 00:00:00 UTC 2022
Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.
Science advances
Eislmayr K,Bestehorn A,Morelli L,Borroni M,Vande Walle L,Lamkanfi M,Kovarik P
14-5931-82 was used in Immunohistochemistry to investigate why interleukin-1α and -1β are not redundant in vivo despite triggering the same receptor and eliciting comparable cellular responses.
Fri Mar 04 00:00:00 UTC 2022
Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.
Science advances
Eislmayr K,Bestehorn A,Morelli L,Borroni M,Vande Walle L,Lamkanfi M,Kovarik P
14-5931-82 was used in Immunohistochemistry to investigate why interleukin-1α and -1β are not redundant in vivo despite triggering the same receptor and eliciting comparable cellular responses.
Fri Mar 04 00:00:00 UTC 2022
Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation.
Oxidative medicine and cellular longevity
Luo T,Zhou X,Qin M,Lin Y,Lin J,Chen G,Liu A,Ouyang D,Chen D,Pan H
14-5931-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to demonstrate that corilagin suppressed the ROS/TXNIP/NLRP3 pathway to repress inflammasome activation and pyroptosis and suggest its potential antioxidative role in alleviating NLRP3-dependent gouty arthritis.
Fri Oct 28 00:00:00 UTC 2022
Therapeutic Ultrasound Halts Progression of Chronic Kidney Disease In Vivo via the Regulation of Markers Associated with Renal Epithelial-Mesenchymal Transition and Senescence.
International journal of molecular sciences
Lin CY,Wang CC,Loh JZ,Chiang TC,Weng TI,Chan DC,Hung KY,Chiang CK,Liu SH
14-5931-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to investigate the therapeutic potential of LIPUS for the treatment of chronic kidney disease (CKD) in two CKD mouse models.
Wed Nov 02 00:00:00 UTC 2022
An epitope-enriched immunogen expands responses to a conserved viral site.
Cell reports
Caradonna TM,Ronsard L,Yousif AS,Windsor IW,Hecht R,Bracamonte-Moreno T,Roffler AA,Maron MJ,Maurer DP,Feldman J,Marchiori E,Barnes RM,Rohrer D,Lonberg N,Oguin TH,Sempowski GD,Kepler TB,Kuraoka M,Lingwood D,Schmidt AG
14-5931-82 was used in Flow Cytometry to show how epitope enrichment expands B cell responses toward conserved epitopes and advances immunogen design approaches for next-generation viral vaccines.
Tue Nov 08 00:00:00 UTC 2022
CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure.
The Journal of experimental medicine
Zhang Y,Ye Y,Tang X,Wang H,Tanaka T,Tian R,Yang X,Wang L,Xiao Y,Hu X,Jin Y,Pang H,Du T,Liu H,Sun L,Xiao S,Dong R,Ferrucci L,Tian Z,Zhang S
14-5931-82 was used in Immunohistochemistry to reveal that chemokine CCL17 is identifiable as a novel therapeutic target in age-related and Ang II-induced pathological cardiac hypertrophy and heart failure.
Mon Aug 01 00:00:00 UTC 2022
Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes.
Cells
Liu G,Li D,Zhang L,Xu Q,Zhuang D,Liu P,Hu L,Deng H,Sun J,Wang S,Zheng B,Guo J,Wu X
14-5931-82 was used in Immunohistochemistry to show that phenformin inhibits the expression of pro-inflammatory cytokines in keratinocytes through the down-regulation of c-Myc expression to play an anti-inflammation function in the skin.
Fri Aug 05 00:00:00 UTC 2022
Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury.
Microbiology spectrum
Zou YT,Zhou J,Zhu JH,Wu CY,Shen H,Zhang W,Zhou SS,Xu JD,Mao Q,Zhang YQ,Long F,Li SL
14-5931-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate that gut microbiota mediates the protective effects of traditional Chinese medicine formula Qiong-Yu-Gao against cisplatin-induced acute kidney injury.
Wed Jun 29 00:00:00 UTC 2022
Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer.
Cancer discovery
Li J,Yuan S,Norgard RJ,Yan F,Sun YH,Kim IK,Merrell AJ,Sela Y,Jiang Y,Bhanu NV,Garcia BA,Vonderheide RH,Blanco A,Stanger BZ
14-5931 was used in Immunohistochemistry to define an epigenetic-transcriptional mechanism by which tumor cells modulate their immune microenvironment and highlights the potential of EGFR inhibitors as immunotherapy sensitizers in PDA.
Mon Mar 01 00:00:00 UTC 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Aug 02 00:00:00 UTC 2021
Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury.
Neural regeneration research
Song WY,Ding H,Dunn T,Gao JL,Labastida JA,Schlagal C,Ning GZ,Feng SQ,Wu P
14-5931-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to suggest that low-dose metformin treatment for subacute spinal cord injury can effectively improve the functional recovery possibly through anti-inflammation and neuroprotection.
Mon Nov 01 00:00:00 UTC 2021
PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion.
Frontiers in cardiovascular medicine
Guo Q,Yaron JR,Wallen JW,Browder KF,Boyd R,Olson TL,Burgin M,Ulrich P,Aliskevich E,Schutz LN,Fromme P,Zhang L,Lucas AR
14-5931 was used in Immunohistochemistry to conclude that Serp-1m5 significantly reduces lung damage and hemorrhage in a pristane model of SLE DAH, providing a new potential therapeutic approach.
Mon Mar 08 00:00:00 UTC 2021
RIPK3 Facilitates Host Resistance to Oral Toxoplasma gondii Infection.
Infection and immunity
Cervantes PW,Martorelli Di Genova B,Erazo Flores BJ,Knoll LJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunohistochemistry
Fri Apr 16 00:00:00 UTC 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Jan 11 00:00:00 UTC 2021
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model.
Molecules (Basel, Switzerland)
Bollenbach M,Nemska S,Wagner P,Camelin G,Daubeuf F,Obrecht A,Villa P,Rognan D,Bihel F,Bourguignon JJ,Schmitt M,Frossard N
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Jan 13 00:00:00 UTC 2021
Retinoic Acid Inhibits Tumor-Associated Mesenchymal Stromal Cell Transformation in Melanoma.
Frontiers in cell and developmental biology
Lou Q,Zhao M,Xu Q,Xie S,Liang Y,Chen J,Yuan L,Wang L,Jiang L,Mou L,Lin D,Zhao M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sat Apr 24 00:00:00 UTC 2021
IFNγ-Producing γ/δ T Cells Accumulate in the Fetal Brain Following Intrauterine Inflammation.
Frontiers in immunology
Lewis EL,Tulina N,Anton L,Brown AG,Porrett PM,Elovitz MA
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Jan 05 00:00:00 UTC 2022
Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201.
PloS one
Trenevska I,Anderson AP,Bentley C,Hassanali T,Wiblin S,Maguire S,Pezzella F,Banham AH,Li D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Sep 29 00:00:00 UTC 2021
Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3.
Nature communications
Zheng Z,Li YN,Jia S,Zhu M,Cao L,Tao M,Jiang J,Zhan S,Chen Y,Gao PJ,Hu W,Wang Y,Shao C,Shi Y
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Oct 27 00:00:00 UTC 2021
Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
Genetics
Grainger AT,Pilar N,Li J,Chen MH,Abramson AM,Becker-Pauly C,Shi W
14-5931-82 was used in Immunohistochemistry-frozen tissue to investigate the role of the Mep1a gene in atherosclerosis, demonstrating that Mep1a deficiency reduced atherosclerotic lesion sizes and impacted inflammation and oxidative stress in mouse models.
Fri Dec 10 00:00:00 UTC 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunohistochemistry
Fri Jun 25 00:00:00 UTC 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Oct 15 00:00:00 UTC 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue May 18 00:00:00 UTC 2021
TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.
Nature communications
Ou Q,Fang JQ,Zhang ZS,Chi Z,Fang J,Xu DY,Lu KZ,Qian MQ,Zhang DY,Guo JP,Gao W,Zhang NR,Pan JP
14-5931-82 was used in Flow Cytometry to investigate the influence of TcpC on neutrophil extracellular trap formation and related mechanisms.
Wed Jun 09 00:00:00 UTC 2021
Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis.
Scientific reports
Kim AD,Kim SE,Leszczynska A,Kaufmann B,Reca A,Kim DJ,Feldstein AE
14-5931-82 was used in Immunohistochemistry to dissect the effects of neutrophil depletion via anti-lymphocyte antigen 6 complex locus G6D (Ly6G) antibodies administration during ongoing high fat-fructose-cholesterol (FFC) diet-induced murine NASH and during inflammation resolution by switching into a low-fat control diet.
Fri Dec 17 00:00:00 UTC 2021
Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1.
Theranostics
Cao Q,Huang Q,Wang YA,Li C
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Jul 23 00:00:00 UTC 2021
Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.
Science advances
Abu El Maaty MA,Grelet E,Keime C,Rerra AI,Gantzer J,Emprou C,Terzic J,Lutzing R,Bornert JM,Laverny G,Metzger D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Jul 01 00:00:00 UTC 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-5931-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 UTC 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Mar 02 00:00:00 UTC 2020
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Cancer immunology research
Li J,Yuan S,Norgard RJ,Yan F,Yamazoe T,Blanco A,Stanger BZ
14-5931 was used in Immunohistochemistry to evaluate the role of the ubiquitin-specific protease 22 (USP22) as a regulator of the immune tumor microenvironment (TME) in PDA.
Sun Mar 01 00:00:00 UTC 2020
Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease.
Journal of Crohn's & colitis
Gong W,Zheng T,Guo K,Fang M,Xie H,Li W,Tang Q,Hong Z,Ren H,Gu G,Wang G,Wu X,Zhao Y,Ren J
14-5931 was used in Flow cytometry/Cell sorting to show that Mincle signaling is significantly elevated in active human CD and experimental colitis, and macrophages are the principal leukocyte subset that up-regulate Mincle signaling.
Wed Dec 02 00:00:00 UTC 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Jun 26 00:00:00 UTC 2020
Circulating extracellular vesicles from patients with valvular heart disease induce neutrophil chemotaxis via FOXO3a and the inhibiting role of dexmedetomidine.
American journal of physiology. Endocrinology and metabolism
Yuan HX,Chen CY,Li YQ,Ning DS,Li Y,Chen YT,Li SX,Fu MX,Li XD,Ma J,Jian YP,Liu DH,Mo ZW,Peng YM,Xu KQ,Ou ZJ,Ou JS
14-5931-82 was used in Immunohistochemistry to reveal a unique mechanism involving vEVs in inducing neutrophils chemotaxis and may provide a novel basis for using DEX in reducing renal dysfunction in valvular heart surgery.
Wed Jul 01 00:00:00 UTC 2020
Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Deng Z,Zhang X,Liu F,Yang C,Shi GP
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sat Feb 01 00:00:00 UTC 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-5931-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 UTC 2020
Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses.
Molecules and cells
Kang W,Park A,Huh JW,You G,Jung DJ,Song M,Lee HK,Kim YM
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Mar 31 00:00:00 UTC 2020
Effects of Hypertonic Saline and Hydroxyethyl Starch on Myeloid-Derived Suppressor Cells in Hemorrhagic Shock Mice under Secondary Bacterial Attack.
BioMed research international
Jiang JK,Hong LJ,Lu YQ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Dec 16 00:00:00 UTC 2020
Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells.
Frontiers in immunology
Kornstädt L,Pierre S,Weigert A,Ebersberger S,Schäufele TJ,Kolbinger A,Schmid T,Cohnen J,Thomas D,Ferreirós N,Brüne B,Ebersberger I,Scholich K
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Jun 21 00:00:00 UTC 2021
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Jan 07 00:00:00 UTC 2020
Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury.
JCI insight
Han SJ,Williams RM,Kim M,Heller DA,D'Agati V,Schmidt-Supprian M,Lee HT
14-5931 was used in Immunohistochemistry to suggest that renal PT NEMO plays a critical role in ischemic AKI by promoting renal tubular inflammation, apoptosis, and necrosis.
Thu Sep 17 00:00:00 UTC 2020
Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury.
JCI insight
Han SJ,Williams RM,Kim M,Heller DA,D'Agati V,Schmidt-Supprian M,Lee HT
14-5931 was used in Immunohistochemistry to suggest that renal PT NEMO plays a critical role in ischemic AKI by promoting renal tubular inflammation, apoptosis, and necrosis.
Thu Sep 17 00:00:00 UTC 2020
The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.
Science advances
Castillo MM,Yang Q,Sigala AS,McKinney DT,Zhan M,Chen KL,Jarzembowski JA,Sood R
14-5931 was used in Immunohistochemistry to investigate the role of thrombotic processes in Placenta-mediated pregnancy complications,.
Sun Nov 01 00:00:00 UTC 2020
The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.
Science advances
Castillo MM,Yang Q,Sigala AS,McKinney DT,Zhan M,Chen KL,Jarzembowski JA,Sood R
14-5931 was used in Immunohistochemistry to investigate the role of thrombotic processes in Placenta-mediated pregnancy complications,.
Sun Nov 01 00:00:00 UTC 2020
Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis.
Scientific reports
Chiang CK,Loh JZ,Yang TH,Huang KT,Wu CT,Guan SS,Liu SH,Hung KY
14-5931-82 was used in Western Blot, Immunohistochemistry to investigate the effects of low intensity pulsed ultrasound within acute kidney injury using a mouse model.
Mon Aug 31 00:00:00 UTC 2020
Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis.
Scientific reports
Chiang CK,Loh JZ,Yang TH,Huang KT,Wu CT,Guan SS,Liu SH,Hung KY
14-5931-82 was used in Western Blot, Immunohistochemistry to investigate the effects of low intensity pulsed ultrasound within acute kidney injury using a mouse model.
Mon Aug 31 00:00:00 UTC 2020
Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis.
Scientific reports
Chiang CK,Loh JZ,Yang TH,Huang KT,Wu CT,Guan SS,Liu SH,Hung KY
14-5931-82 was used in Western Blot, Immunohistochemistry to investigate the effects of low intensity pulsed ultrasound within acute kidney injury using a mouse model.
Mon Aug 31 00:00:00 UTC 2020
Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis.
Scientific reports
Chiang CK,Loh JZ,Yang TH,Huang KT,Wu CT,Guan SS,Liu SH,Hung KY
14-5931-82 was used in Western Blot, Immunohistochemistry to investigate the effects of low intensity pulsed ultrasound within acute kidney injury using a mouse model.
Mon Aug 31 00:00:00 UTC 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Sep 17 00:00:00 UTC 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Mar 31 00:00:00 UTC 2020
Sensing and signaling of immunogenic extracellular RNAs restrain group 2 innate lymphoid cell-driven acute lung inflammation and airway hyperresponsiveness.
PloS one
She L,Alanazi HH,Yan L,Brooks EG,Dube PH,Xiang Y,Zhang F,Sun Y,Liu Y,Zhang X,Li XD
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Sep 24 00:00:00 UTC 2020
Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis.
Journal of clinical & cellular immunology
Alkhateeb T,Bah I,Kumbhare A,Youssef D,Yao ZQ,McCall CE,Gazzar ME
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sat Aug 13 00:00:00 UTC 2022
Protocol for Flow Cytometric Detection of Immune Cell Infiltration in the Epidermis and Dermis of a Psoriasis Mouse Model.
STAR protocols
Lou F,Sun Y,Wang H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Dec 18 00:00:00 UTC 2020
Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection.
Science advances
Park MY,Kim HS,Lee HY,Zabel BA,Bae YS
14-5931-82 was used in Flow Cytometry to find a previously unidentified pathogenic CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus.
Wed Jan 01 00:00:00 UTC 2020
Recombinant Myxoma Virus-Derived Immune Modulator M-T7 Accelerates Cutaneous Wound Healing and Improves Tissue Remodeling.
Pharmaceutics
Yaron JR,Zhang L,Guo Q,Awo EA,Burgin M,Schutz LN,Zhang N,Kilbourne J,Daggett-Vondras J,Lowe KM,Lucas AR
14-5931 was used in Immunohistochemistry to study the therapeutic potential of virus-derived glycoprotein M-T7 in wound healing.
Thu Oct 22 00:00:00 UTC 2020
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
The Journal of biological chemistry
Hohl M,Mayr M,Lang L,Nickel AG,Barallobre-Barreiro J,Yin X,Speer T,Selejan SR,Goettsch C,Erb K,Fecher-Trost C,Reil JC,Linz B,Ruf S,Hübschle T,Maack C,Böhm M,Sadowski T,Linz D
14-5931 was used in Immunohistochemistry to evaluate the effects of CatA overexpression on LV remodeling.
Fri Sep 04 00:00:00 UTC 2020
Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H.
The Journal of clinical investigation
Gui F,Zhang Y,Wan J,Zhan X,Yao Y,Li Y,Haddock AN,Shi J,Guo J,Chen J,Zhu X,Edenfield BH,Zhuang L,Hu C,Wang Y,Mukhopadhyay D,Radisky ES,Zhang L,Lugea A,Pandol SJ,Bi Y,Ji B
14-5931-82 was used in Immunohistochemistry to develop a mouse model by inserting a full-length human PRSS1R122H gene, the most commonly mutated gene in human HP, into mice.
Thu Jan 02 00:00:00 UTC 2020
Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.
eLife
Adapala NS,Swarnkar G,Arra M,Shen J,Mbalaviele G,Ke K,Abu-Amer Y
14-5931 was used in Flow cytometry/Cell sorting to suggest that NEMO serves as a toolkit to fine-tune specific signals in physiologic and pathologic conditions.
Mon Mar 23 00:00:00 UTC 2020
Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation.
Cell reports
Valet C,Batut A,Vauclard A,Dortignac A,Bellio M,Payrastre B,Valet P,Severin S
14-5931-82 was used in Flow Cytometry to demonstrate the influence of adipocytes on megakaryocyte development via fatty acid transfer.
Tue Jul 07 00:00:00 UTC 2020
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-5931 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 UTC 2019
Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy.
Chem
Ni K,Aung T,Li S,Fatuzzo N,Liang X,Lin W
14-5931 was used in Immunocytochemistry-immunoflourescence to report the use of a Cu-porphyrin nanoscale metal-organic framework (nMOF) to mediate synergistic hormone-triggered chemodynamic therapy (CDT).
Thu Jul 11 00:00:00 UTC 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
14-5931 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 UTC 2019
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.
The Journal of clinical investigation
Calvente CJ,Tameda M,Johnson CD,Del Pilar H,Lin YC,Adronikou N,De Mollerat Du Jeu X,Llorente C,Boyer J,Feldstein AE
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Jul 11 00:00:00 UTC 2019
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-5931 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 UTC 2019
The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration.
The Journal of clinical investigation
Uchida M,Maier B,Waghwani HK,Selivanovitch E,Pay SL,Avera J,Yun E,Sandoval RM,Molitoris BA,Zollman A,Douglas T,Hato T
14-5931-82 was used in Immunohistochemistry to show that DNA-binding protein from starved cells (Dps) is able to cross the glomerular filtration barrier and is endocytosed by the renal proximal tubules.
Tue Sep 03 00:00:00 UTC 2019
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
PLoS biology
Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A
14-5931-82 was used in Flow Cytometry to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.
Fri Mar 01 00:00:00 UTC 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-5931-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 UTC 2019
Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.
Mammalian genome : official journal of the International Mammalian Genome Society
Avery JT,Jimenez RV,Blake JL,Wright TT,Leόn-Ruiz B,Schoeb TR,Szalai AJ,Bullard DC
14-5931-82 was used in Flow Cytometry to suggest that the 77His variant of CD11b can compromise the ability of DCs to induce antigen-driven T cell proliferation.
Tue Oct 01 00:00:00 UTC 2019
The role of platelets in mediating a response to human influenza infection.
Nature communications
Koupenova M,Corkrey HA,Vitseva O,Manni G,Pang CJ,Clancy L,Yao C,Rade J,Levy D,Wang JP,Finberg RW,Kurt-Jones EA,Freedman JE
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunocytochemistry
Tue Apr 16 00:00:00 UTC 2019
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.
Cell death discovery
Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Sep 30 00:00:00 UTC 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-5931 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 UTC 2021
Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
Scientific reports
Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H
14-5931 was used in Immunohistochemistry to show epithelial EP4 is crucial in maintaining intestinal homeostasis via the epithelial PGE2/EP4 axis.
Wed Oct 23 00:00:00 UTC 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-5931 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 UTC 2020
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Nature
Garaycoechea JI,Crossan GP,Langevin F,Mulderrig L,Louzada S,Yang F,Guilbaud G,Park N,Roerink S,Nik-Zainal S,Stratton MR,Patel KJ
14-5931 was used in Flow cytometry/Cell sorting to identify how the choice of DNA-repair pathway and a stringent p53 response limit the transmission of aldehyde-induced mutations in stem cells.
Thu Jan 11 00:00:00 UTC 2018
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Feb 20 00:00:00 UTC 2018
Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis.
Cellular & molecular immunology
Lu Y,Liu H,Bi Y,Yang H,Li Y,Wang J,Zhang Z,Wang Y,Li C,Jia A,Han L,Hu Y,Zhao Y,Wang R,Liu G
14-5931 was used in Flow cytometry/Cell sorting to reveal the dysregulation of glucocorticoid receptor expression in myeloid-derived suppressor cells during innate immunological hepatic injury and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.
Fri Jun 01 00:00:00 UTC 2018
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.
The Journal of experimental medicine
Malireddi RKS,Gurung P,Mavuluri J,Dasari TK,Klco JM,Chi H,Kanneganti TD
14-5931 was used in Flow cytometry/Cell sorting to identify a critical role for TAK1 in maintaining NLRP3 inflammasome quiescence and preserving cellular homeostasis and survival.
Mon Apr 02 00:00:00 UTC 2018
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB
14-5931 was used in Immunohistochemistry to show that p38/MAPKAP Kinase 2 activity in the myeloid compartment promotes tumour progression by supporting tumour neoangiogenesis in vivo.
Tue May 01 00:00:00 UTC 2018
Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
Arteriosclerosis, thrombosis, and vascular biology
Karasawa T,Kawashima A,Usui-Kawanishi F,Watanabe S,Kimura H,Kamata R,Shirasuna K,Koyama Y,Sato-Tomita A,Matsuzaka T,Tomoda H,Park SY,Shibayama N,Shimano H,Kasahara T,Takahashi M
14-5931 was used in Immunohistochemistry to demonstrate that excess SFAs cause intracellular crystallization and subsequent lysosomal dysfunction, leading to the activation of the NLRP3 inflammasome, and provide novel insights into the pathogenesis of metabolic diseases.
Sun Apr 01 00:00:00 UTC 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
14-5931 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 UTC 2018
TRAIL-Dependent Resolution of Pulmonary Fibrosis.
Mediators of inflammation
Habiel DM,Moreira AP,Ismailoglu UB,Dunleavy MP,Cavassani KA,van Rooijen N,Coelho AL,Hogaboam CM
14-5931 was used in a Functional assay to identify TRAIL+ myeloid cells as a critical mechanism in the resolution of pulmonary fibrosis, and strategies directed at promoting its function might have therapeutic potential in IPF.
Mon Sep 17 00:00:00 UTC 2018
Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation.
Aging
Geng X,Wang X,Luo M,Xing M,Wu Y,Li W,Chen Z,Shen H,Ying S
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Jun 26 00:00:00 UTC 2018
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.
mSphere
Quach D,Collins F,Parameswaran N,McCabe L,Britton RA
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
Antiviral effects of ferric ammonium citrate.
Cell discovery
Wang H,Li Z,Niu J,Xu Y,Ma L,Lu A,Wang X,Qian Z,Huang Z,Jin X,Leng Q,Wang J,Zhong J,Sun B,Meng G
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Sep 29 00:00:00 UTC 2020
Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.
Oncotarget
Mertens B,Cristina de Araujo Nogueira T,Topalis D,Stranska R,Snoeck R,Andrei G
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Apr 24 00:00:00 UTC 2018
Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.
JCI insight
Flemming S,Luissint AC,Nusrat A,Parkos CA
14-5931 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to analyse leukocyte transepithelial migration using an in vivo murine colonic loop model.
Thu Oct 18 00:00:00 UTC 2018
IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity.
Scientific reports
Takamori A,Nambu A,Sato K,Yamaguchi S,Matsuda K,Numata T,Sugawara T,Yoshizaki T,Arae K,Morita H,Matsumoto K,Sudo K,Okumura K,Kitaura J,Matsuda H,Nakae S
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of IL-31 in development of contact dermatitis/contact hypersensitivity (CHS), which is mediated by hapten-specific T cells, including Th2 cells, in IL-31-deficient (Il31-/-) mice.
Fri Apr 27 00:00:00 UTC 2018
The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.
iScience
Maruyama K,Takayama Y,Sugisawa E,Yamanoi Y,Yokawa T,Kondo T,Ishibashi KI,Sahoo BR,Takemura N,Mori Y,Kanemaru H,Kumagai Y,Martino MM,Yoshioka Y,Nishijo H,Tanaka H,Sasaki A,Ohno N,Iwakura Y,Moriyama Y,Nomura M,Akira S,Tominaga M
14-5931 was used in Immunodepletion to indicate that Dectin-1 and VNUT mediated innate sensory mechanisms that detect fungal infection.
Fri Aug 31 00:00:00 UTC 2018
Cytokine Expression and Macrophage Localization in Xenograft and Allograft Tumor Models Stimulated with Lipopolysaccharide.
International journal of molecular sciences
Masuda J,Shigehiro T,Matsumoto T,Satoh A,Mizutani A,Umemura C,Saito S,Kijihira M,Takayama E,Seno A,Murakami H,Seno M
14-5931 was used in Flow cytometry/Cell sorting to define the differences in the functions of macrophages and dendritic cells in the xenograft and the allograft.
Mon Apr 23 00:00:00 UTC 2018
Dietary Supplementation of Selenoneine-Containing Tuna Dark Muscle Extract Effectively Reduces Pathology of Experimental Colorectal Cancers in Mice.
Nutrients
Masuda J,Umemura C,Yokozawa M,Yamauchi K,Seko T,Yamashita M,Yamashita Y
14-5931 was used in Flow cytometry/Cell sorting to suggest that dietary STDME may be an effective agent for reducing colorectal tumor progression.
Thu Sep 27 00:00:00 UTC 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-5931 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 UTC 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 UTC 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
14-5931 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 UTC 2018
Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
International journal of nanomedicine
Pan H,Palekar RU,Hou KK,Bacon J,Yan H,Springer LE,Akk A,Yang L,Miller MJ,Pham CT,Schlesinger PH,Wickline SA
14-5931-82 was used in Flow cytometry/Cell sorting to devise a flexible platform for preventing the inflammatory drivers at their source to preserve plaque endothelium and mitigate procoagulant risk.
Mon Oct 29 00:00:00 UTC 2018
Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury.
Circulation research
Mittal M,Nepal S,Tsukasaki Y,Hecquet CM,Soni D,Rehman J,Tiruppathi C,Malik AB
14-5931 was used in Functional assays to demonstrate that blocking TRPM2 activation in ECs is a potentially important means of therapeutically modifying PMN-mediated vascular inflammation.
Fri Oct 13 00:00:00 UTC 2017
A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.
The Journal of clinical investigation
Sindhava VJ,Oropallo MA,Moody K,Naradikian M,Higdon LE,Zhou L,Myles A,Green N,Nündel K,Stohl W,Schmidt AM,Cao W,Dorta-Estremera S,Kambayashi T,Marshak-Rothstein A,Cancro MP
14-5931 was used in Flow cytometry/Cell sorting to describe a relationship among the B cell receptor, TLR9, and cytokine signals that regulate B cell responses to DNA-containing antigens.
Mon May 01 00:00:00 UTC 2017
TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation.
The Journal of clinical investigation
Whitehead GS,Thomas SY,Shalaby KH,Nakano K,Moran TP,Ward JM,Flake GP,Nakano H,Cook DN
14-5931 was used in functional experiments to study the potential role of TNF in TLR ligand and protease mediated allergic airway inflammation.
Fri Sep 01 00:00:00 UTC 2017
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
The Journal of experimental medicine
Singh PB,Pua HH,Happ HC,Schneider C,von Moltke J,Locksley RM,Baumjohann D,Ansel KM
14-5931 was used in Flow cytometry/Cell sorting to establish the physiological requirements for miRNAs in ILC2 homeostasis and immune function ans compare the global miRNA repertoire of resting and activated ILC2s and T helper type 2 cells.
Mon Dec 04 00:00:00 UTC 2017
Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.
Proceedings of the National Academy of Sciences of the United States of America
Bao Y,Wu X,Chen J,Hu X,Zeng F,Cheng J,Jin H,Lin X,Chen LF
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue May 16 00:00:00 UTC 2017
Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.
Frontiers in immunology
Powell DA,Frelinger JA
14-5931 was used in Flow cytometry/Cell sorting to show the role of Slc11a1 in resistance to pulmonary Francisella infection in mice.
Wed Nov 20 00:00:00 UTC 2019
Galectin-3-null mice display defective neutrophil clearance during acute inflammation.
Journal of leukocyte biology
Wright RD,Souza PR,Flak MB,Thedchanamoorthy P,Norling LV,Cooper D
14-5931 was used in Flow cytometry/Cell sorting to show murine Galectin-3 mediates neutrophil clearance during acute inflammation.
Wed Mar 01 00:00:00 UTC 2017
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.
Journal of molecular and cellular cardiology
Lynch TL,Ismahil MA,Jegga AG,Zilliox MJ,Troidl C,Prabhu SD,Sadayappan S
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sun Jan 01 00:00:00 UTC 2017
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.
Journal of molecular and cellular cardiology
Lynch TL,Ismahil MA,Jegga AG,Zilliox MJ,Troidl C,Prabhu SD,Sadayappan S
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sun Jan 01 00:00:00 UTC 2017
Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Al-Khami AA,Ghonim MA,Del Valle L,Ibba SV,Zheng L,Pyakurel K,Okpechi SC,Garay J,Wyczechowska D,Sanchez-Pino MD,Rodriguez PC,Boulares AH,Ochoa AC
14-5931 was used in Immunohistochemistry to show if FAO might play a role in the development of asthma-like traits and whether the inhibition of this metabolic pathway could represent a novel therapeutic approach.
Fri Sep 01 00:00:00 UTC 2017
Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation.
International journal of molecular medicine
Zhang B,Wang B,Cao S,Wang Y,Wu D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2017
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA biology
Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu May 04 00:00:00 UTC 2017
Comparison of the roles of house dust mite allergens, ovalbumin and lipopolysaccharides in the sensitization of mice to establish a model of severe neutrophilic asthma.
Experimental and therapeutic medicine
Jia A,Wang Y,Sun W,Xiao B,Mu L,Wei Y,Xu L,Peng C,Zhang D,Shen H,Xiang X
14-5931 was used in Immunohistochemistry to demonstrate the sensitisation of mouse models with various factors such as lipopolysaccharides and ovalbumin to develop a severe asthma model with a predominantly neutrophilic inflammatory phenotype.
Fri Sep 01 00:00:00 UTC 2017
One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet.
International journal of molecular sciences
Schmidt A,Woedtke TV,Stenzel J,Lindner T,Polei S,Vollmar B,Bekeschus S
14-5931 was used in Immunohistochemistry on paraffin embedded tissues to investigate the longterm side effects of repetitive plasma treatment in a rodent full-thickness ear wound model.
Wed Apr 19 00:00:00 UTC 2017
Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection.
Frontiers in cellular and infection microbiology
Esposito R,Morello S,Vllahu M,Eletto D,Porta A,Tosco A
Mon Jul 09 00:00:00 UTC 2018
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Dec 12 00:00:00 UTC 2017
MiR-125a Is a critical modulator for neutrophil development.
PLoS genetics
Qin Y,Wu L,Ouyang Y,Zhou P,Zhou H,Wang Y,Ma J,Zhang J,Chen Y,Qian J,Tang Y,Shen N
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sun Oct 01 00:00:00 UTC 2017
Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis.
Scientific reports
Leal AC,Mizurini DM,Gomes T,Rochael NC,Saraiva EM,Dias MS,Werneck CC,Sielski MS,Vicente CP,Monteiro RQ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunohistochemistry
Tue Jul 25 00:00:00 UTC 2017
BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.
Scientific reports
Shim DW,Shin WY,Yu SH,Kim BH,Ye SK,Koppula S,Won HS,Kang TB,Lee KH
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Nov 08 00:00:00 UTC 2017
Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection.
mBio
Leyva-Grado VH,Ermler ME,Schotsaert M,Gonzalez MG,Gillespie V,Lim JK,García-Sastre A
14-5931 was used in Flow cytometry/Cell sorting to implicate P2X7r in the induction of an exacerbated local immune response to influenza virus and help us to better understand the mechanisms leading to the lung immunopathology observed during severe viral infections.
Tue Mar 28 00:00:00 UTC 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
14-5931 was used in Flow Cytometry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.
Fri Dec 01 00:00:00 UTC 2017
Healing of Preterm Ruptured Fetal Membranes.
Scientific reports
Mogami H,Hari Kishore A,Akgul Y,Word RA
14-5931 was used in Immunofluorescence-paraffin to provide novel insights regarding unique healing mechanisms of amnion.
Fri Oct 13 00:00:00 UTC 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-5931-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 UTC 2017
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.
PloS one
Nguyen-McCarty M,Klein PS
14-5931 was used in Flow cytometry/Cell sorting to identify the downstream effectors of mTORC1 in hematopoietic stem cells.
Fri Sep 15 00:00:00 UTC 2017
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.
PloS one
Niikura M,Inoue SI,Mineo S,Asahi H,Kobayashi F
14-5931 was used in an ELISA assay to explore the role of IFN-γ receptor 1 signalling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65.
Wed Nov 29 00:00:00 UTC 2017
Oxidized CaMKII promotes asthma through the activation of mast cells.
JCI insight
Qu J,Do DC,Zhou Y,Luczak E,Mitzner W,Anderson ME,Gao P
14-5931 was used in Flow cytometry/Cell sorting to test the effect of ox-CaMKII on IgE-mediated mast cell activation in an allergen-induced mouse model of asthma.
Thu Jan 12 00:00:00 UTC 2017
Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.
Stem cell research & therapy
Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ
14-5931 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.
Mon Jan 23 00:00:00 UTC 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-5931 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 UTC 2017
The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury.
Cell death & disease
Zhang C,Wang S,Li J,Zhang W,Zheng L,Yang C,Zhu T,Rong R
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of myeloid-derived suppressor cells and mTOR signalling in the protection of acute kidney injury.
Thu Mar 23 00:00:00 UTC 2017
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
Nature biotechnology
Vegas AJ,Veiseh O,Doloff JC,Ma M,Tam HH,Bratlie K,Li J,Bader AR,Langan E,Olejnik K,Fenton P,Kang JW,Hollister-Locke J,Bochenek MA,Chiu A,Siebert S,Tang K,Jhunjhunwala S,Aresta-Dasilva S,Dholakia N,Thakrar R,Vietti T,Chen M,Cohen J,Siniakowicz K,Qi M,McGarrigle J,Graham AC,Lyle S,Harlan DM,Greiner DL,Oberholzer J,Weir GC,Langer R,Anderson DG
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Aug 25 00:00:00 UTC 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
14-5931 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 UTC 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-5931 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 UTC 2016
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
The Journal of clinical investigation
Wang J,Mizui M,Zeng LF,Bronson R,Finnell M,Terhorst C,Kyttaris VC,Tsokos GC,Zhang ZY,Kontaridis MI
14-5931 was used in Flow cytometry/Cell sorting to explore the effect of inhibiting SHP2 on T cell activation, ERK/MAPK signalling and the production of cytokines associated with organ damage in sufferers of systemic lupus erythematosus.
Wed Jun 01 00:00:00 UTC 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-5931 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 UTC 2016
Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy.
Journal of autoimmunity
Yang JB,Wang YH,Yang W,Lu FT,Ma HD,Zhao ZB,Jia YJ,Tang W,Tsuneyama K,Ridgway WM,Gershwin ME,Lian ZX
14-5931 was used in Flow cytometry/Cell sorting to investigate the pathways that lead to pathology in a model of primary biliary cirrhosis, showing that CD4(-/-) mice had more severe pathology and parabiosis reduced chalangitis.
Fri Jan 01 00:00:00 UTC 2016
Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression.
The Journal of pathology
Wang J,De Veirman K,Faict S,Frassanito MA,Ribatti D,Vacca A,Menu E
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2016
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Sep 01 00:00:00 UTC 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sat Oct 01 00:00:00 UTC 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-5931 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 UTC 2016
The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.
Leukemia research
Mian YA,Zeleznik-Le NJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Jul 01 00:00:00 UTC 2016
Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.
Infection and immunity
Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM
14-5931 was used in Immunohistochemistry to investigate T. cruzi infection as a trigger of vasculitis.
Fri Apr 01 00:00:00 UTC 2016
Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model.
PloS one
Liu Q,Babadjouni R,Radwanski R,Cheng H,Patel A,Hodis DM,He S,Baumbacher P,Russin JJ,Morgan TE,Sioutas C,Finch CE,Mack WJ
Tue Aug 23 00:00:00 UTC 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Aug 09 00:00:00 UTC 2016
Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.
BMC genomics
Leist SR,Pilzner C,van den Brand JM,Dengler L,Geffers R,Kuiken T,Balling R,Kollmus H,Schughart K
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sat Feb 27 00:00:00 UTC 2016
Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.
Cell death & disease
Di Siena S,Gimmelli R,Nori SL,Barbagallo F,Campolo F,Dolci S,Rossi P,Venneri MA,Giannetta E,Gianfrilli D,Feigenbaum L,Lenzi A,Naro F,Cianflone E,Mancuso T,Torella D,Isidori AM,Pellegrini M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Jul 28 00:00:00 UTC 2016
Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.
Cell death & disease
Di Siena S,Gimmelli R,Nori SL,Barbagallo F,Campolo F,Dolci S,Rossi P,Venneri MA,Giannetta E,Gianfrilli D,Feigenbaum L,Lenzi A,Naro F,Cianflone E,Mancuso T,Torella D,Isidori AM,Pellegrini M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Jul 28 00:00:00 UTC 2016
C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease.
Oncotarget
Liu SH,Wu CT,Huang KH,Wang CC,Guan SS,Chen LP,Chiang CK
Tue Apr 19 00:00:00 UTC 2016
Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice.
Scientific reports
Ricard C,Tchoghandjian A,Luche H,Grenot P,Figarella-Branger D,Rougon G,Malissen M,Debarbieux F
14593182 was used in immunohistochemistry to characterize the cellular basis and dynamics of the inflammatory microenvironment present in glioblastomas multiforme
Thu May 19 00:00:00 UTC 2016
5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation.
Oncotarget
Wang J,Peng L,Zhang R,Zheng Z,Chen C,Cheung KL,Cui M,Bian G,Xu F,Chiang D,Hu Y,Chen Y,Lu G,Yang J,Zhang H,Yang J,Zhu H,Chen SH,Liu K,Zhou MM,Sikora AG,Li L,Jiang B,Xiong H
14-5931 was used in Flow cytometry/Cell sorting to investigate the function of 5-Fluorouracil in the modulation of immune cells.
Tue Apr 12 00:00:00 UTC 2016
Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis.
PloS one
Oliveira MC,Tavares LP,Vago JP,Batista NV,Queiroz-Junior CM,Vieira AT,Menezes GB,Sousa LP,van de Loo FA,Teixeira MM,Amaral FA,Ferreira AV
14-5931-82 was used in Immunodepletion to investigate the role of tumour necrosis factor in the metabolic alterations associated with arthritis.
Wed Jun 29 00:00:00 UTC 2016
Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.
Scientific reports
Song ZH,Li ZY,Li DD,Fang WN,Liu HY,Yang DD,Meng CY,Yang Y,Peng JP
14-5931 was used in Immunohistochemistry on frozen tissues to identify a new mechanism by which seminal plasma could influence inflammation in the uterus through the γδ T/IL-17 pathway.
Mon Apr 25 00:00:00 UTC 2016
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Nature medicine
Alam MS,Gaida MM,Bergmann F,Lasitschka F,Giese T,Giese NA,Hackert T,Hinz U,Hussain SP,Kozlov SV,Ashwell JD
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that TCR-mediated activation of CD4+ TIL results in alternative p38 activation and production of pro-tumorigenic factors.
Sun Nov 01 00:00:00 UTC 2015
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
14-5931 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 UTC 2015
CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.
Immunity
Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW
14-5931 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cells locate virus-infected cells within tissues, showing that the CXCR3 chemokine receptor enables migration for the destruction of virus-infected cells.
Tue Mar 17 00:00:00 UTC 2015
Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.
Blood
Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Nov 19 00:00:00 UTC 2015
Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses.
Blood
Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ
14-5931 was used in Flow cytometry/Cell sorting to study the rapidity with which peripheral inflammation modifies the bone marrow compartment, and demonstrate that such modifications regulate acute IgM production within this organ.
Thu Sep 03 00:00:00 UTC 2015
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.
The Journal of clinical investigation
Hitchcock JR,Cook CN,Bobat S,Ross EA,Flores-Langarica A,Lowe KL,Khan M,Dominguez-Medina CC,Lax S,Carvalho-Gaspar M,Hubscher S,Rainger GE,Cobbold M,Buckley CD,Mitchell TJ,Mitchell A,Jones ND,Van Rooijen N,Kirchhofer D,Henderson IR,Adams DH,Watson SP,Cunningham AF
14-5931 was used in Immunohistochemistry to indicate that infection-driven thrombosis follows local inflammation, upregulation of podoplanin and platelet activation.
Tue Dec 01 00:00:00 UTC 2015
Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.
The Journal of experimental medicine
Ruppert R,Moser M,Sperandio M,Rognoni E,Orban M,Liu WH,Schulz AS,Oostendorp RA,Massberg S,Fässler R
14-5931 was used in Flow cytometry/Cell sorting to highlight a role for Kindlin-3 in the control of haematopoietic stem and progenitor cell homing function.
Mon Aug 24 00:00:00 UTC 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-5931 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 UTC 2015
Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.
Hepatology (Baltimore, Md.)
Marques PE,Oliveira AG,Pereira RV,David BA,Gomides LF,Saraiva AM,Pires DA,Novaes JT,Patricio DO,Cisalpino D,Menezes-Garcia Z,Leevy WM,Chapman SE,Mahecha G,Marques RE,Guabiraba R,Martins VP,Souza DG,Mansur DS,Teixeira MM,Leite MF,Menezes GB
14-5931 was used in Immunodepletion to examine whether DNA released from damaged hepatocytes accumulates into necrotic liver, and study the impact of its recognition by the immune system.
Thu Jan 01 00:00:00 UTC 2015
The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Genes & development
Miyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C
14-5931 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells.
Sun Feb 15 00:00:00 UTC 2015
Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment.
Cancer immunology research
Danelli L,Frossi B,Gri G,Mion F,Guarnotta C,Bongiovanni L,Tripodo C,Mariuzzi L,Marzinotto S,Rigoni A,Blank U,Colombo MP,Pucillo CE
14-5931 was used in Immunohistochemistry-immunofluorescence to examine the interactions between myeloid-derived suppressor cells and mast cells in the mucosa of patients with colon carcinoma.
Thu Jan 01 00:00:00 UTC 2015
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
PLoS biology
Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ
14-5931 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
Tue Dec 01 00:00:00 UTC 2015
The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages.
eLife
Park C,Arthos J,Cicala C,Kehrl JH
14-5931 was used in Flow cytometry/Cell sorting to reveal a specialised lymph node antigen delivery system capable of delivering gp120 and other pathogen-derived glycoproteins to B cells.
Mon Aug 10 00:00:00 UTC 2015
IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.
Mucosal immunology
Jung Y,Wen T,Mingler MK,Caldwell JM,Wang YH,Chaplin DD,Lee EH,Jang MH,Woo SY,Seoh JY,Miyasaka M,Rothenberg ME
14-5931 was used in Flow cytometry/Cell sorting to show that eosinophils are required for mucosal production of IgA and development of Peyer's patches in the gut.
Wed Jul 01 00:00:00 UTC 2015
Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.
Mucosal immunology
Jiang TT,Chaturvedi V,Ertelt JM,Xin L,Clark DR,Kinder JM,Way SS
14-5931 was used in Flow cytometry/Cell sorting to study susceptibility against Candida albicans fungal infectiong following eradication of commensal enteric bacteria, showing loss of commensal bacteria enhances antifungal immunity through robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, suggesting that enteric bacteria restrains activation of some immune components.
Wed Jul 01 00:00:00 UTC 2015
Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.
Mucosal immunology
Visekruna A,Linnerz T,Martinic V,Vachharajani N,Hartmann S,Harb H,Joeris T,Pfefferle PI,Hofer MJ,Steinhoff U
14-5931 was used in Flow cytometry/Cell sorting to investigate the role c-Rel plays in regulating innate lymphoid cells which induce anti-CD40-mediated innate colitis in mice.
Sun Mar 01 00:00:00 UTC 2015
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine
Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A
14-5931 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.
Thu Oct 01 00:00:00 UTC 2015
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS pathogens
Napier RJ,Norris BA,Swimm A,Giver CR,Harris WA,Laval J,Napier BA,Patel G,Crump R,Peng Z,Bornmann W,Pulendran B,Buller RM,Weiss DS,Tirouvanziam R,Waller EK,Kalman D
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that potentiation of the immune response by imatinib may facilitate clearance of diverse microbial pathogens.
Sun Mar 01 00:00:00 UTC 2015
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS pathogens
Napier RJ,Norris BA,Swimm A,Giver CR,Harris WA,Laval J,Napier BA,Patel G,Crump R,Peng Z,Bornmann W,Pulendran B,Buller RM,Weiss DS,Tirouvanziam R,Waller EK,Kalman D
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that potentiation of the immune response by imatinib may facilitate clearance of diverse microbial pathogens.
Sun Mar 01 00:00:00 UTC 2015
The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection.
PLoS pathogens
Dalton JE,Glover AC,Hoodless L,Lim EK,Beattie L,Kirby A,Kaye PM
14-5931 was used in Flow cytometry/Cell sorting to investigate how Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic infection.
Sun Feb 01 00:00:00 UTC 2015
Dopamine inhibits the function of Gr-1+CD115+ myeloid-derived suppressor cells through D1-like receptors and enhances anti-tumor immunity.
Journal of leukocyte biology
Wu J,Zhang R,Tang N,Gong Z,Zhou J,Chen Y,Chen K,Cai W
14-5931-82 was used in Immunodepletion to investigate the therapeutic mechanism and efficacy of DA on the inhibition of cancer development.
Thu Jan 01 00:00:00 UTC 2015
The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer.
Cancer gene therapy
Boone BA,Orlichenko L,Schapiro NE,Loughran P,Gianfrate GC,Ellis JT,Singhi AD,Kang R,Tang D,Lotze MT,Zeh HJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Mon Jun 01 00:00:00 UTC 2015
The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer.
Cancer gene therapy
Boone BA,Orlichenko L,Schapiro NE,Loughran P,Gianfrate GC,Ellis JT,Singhi AD,Kang R,Tang D,Lotze MT,Zeh HJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Mon Jun 01 00:00:00 UTC 2015
Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Russkamp NF,Ruemmler R,Roewe J,Moore BB,Ward PA,Bosmann M
14-5931 was used in Immunofluorescence to determine that the detrimental effects of C5a are partly mediated through CCR5 activation downstream of C5aR1.
Tue Sep 01 00:00:00 UTC 2015
Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Lobo PI,Schlegel KH,Bajwa A,Huang L,Kurmaeva E,Wang B,Ye H,Tedder TF,Kinsey GR,Okusa MD
14-5931 was used in Flow cytometry/Cell sorting to investigate how natural IgM anti-leukocyte Abs can switch BMDC to a regulatory phenotype despite the presence of LPS that ordinarily induces BMDC maturation.
Tue Dec 01 00:00:00 UTC 2015
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones DD,Wilmore JR,Allman D
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.
Sun Nov 15 00:00:00 UTC 2015
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
14-5931 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 UTC 2015
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
Journal of immunology (Baltimore, Md. : 1950)
Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE
14-5931 was used in Flow cytometry/Cell sorting to determine whether loss of Stard7 expression promotes allergic responses, showing that haploinsufficiency for Stard7 is associated with enhanced allergic responses.
Mon Jun 15 00:00:00 UTC 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
14-5931 was used in Flow cytometry/Cell sorting to identify a novel leukocyte receptor, TARM1, and investigate the mechanisms underlying its proinflammatory effects.
Thu Oct 01 00:00:00 UTC 2015
The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells.
Journal of cellular and molecular medicine
Ji J,Griffiths KL,Milburn PJ,Hirst TR,O'Neill HC
14-5931 was used in Magnetic cell separation to investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen.
Sat Aug 01 00:00:00 UTC 2015
A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Keswani RK,Yoon GS,Sud S,Stringer KA,Rosania GR
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2015
Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia.
Tissue engineering. Part A
Anderson EM,Kwee BJ,Lewin SA,Raimondo T,Mehta M,Mooney DJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Oct 13 00:00:00 UTC 2015
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oncoimmunology
Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Sun Mar 01 00:00:00 UTC 2015
Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature.
Nature communications
Kolaczkowska E,Jenne CN,Surewaard BG,Thanabalasuriar A,Lee WY,Sanz MJ,Mowen K,Opdenakker G,Kubes P
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Thu Mar 26 00:00:00 UTC 2015
The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells.
Oncotarget
Wang J,De Veirman K,De Beule N,Maes K,De Bruyne E,Van Valckenborgh E,Vanderkerken K,Menu E
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Dec 22 00:00:00 UTC 2015
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Nature communications
Koh HS,Chang CY,Jeon SB,Yoon HJ,Ahn YH,Kim HS,Kim IH,Jeon SH,Johnson RS,Park EJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Fri Mar 20 00:00:00 UTC 2015
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
PloS one
Szulzewsky F,Pelz A,Feng X,Synowitz M,Markovic D,Langmann T,Holtman IR,Wang X,Eggen BJ,Boddeke HW,Hambardzumyan D,Wolf SA,Kettenmann H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2016
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-5931 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 UTC 2015
Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas.
Oncoimmunology
Ahn B,Kohanbash G,Ohkuri T,Kosaka A,Chen X,Ikeura M,Wang TC,Okada H
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of HDC in the glioma microenvironment via maturation of myeloid cells and resulting activation of CD8(+) T cells.
Sun Nov 01 00:00:00 UTC 2015
Differential Mycobacterium bovis BCG vaccine-derived efficacy in C3Heb/FeJ and C3H/HeOuJ mice exposed to a clinical strain of Mycobacterium tuberculosis.
Clinical and vaccine immunology : CVI
Henao-Tamayo M,Obregón-Henao A,Creissen E,Shanley C,Orme I,Ordway DJ
14-5931 was used in Immunohistochemistry to evaluate the impact of prior Mycobacterium bovis bacillus Calmette-Guérin vaccination of mice on exposure to a low-dose aerosol of Mycobacterium tuberculosis.
Thu Jan 01 00:00:00 UTC 2015
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.
Scientific reports
Moniaga CS,Watanabe S,Honda T,Nielsen S,Hara-Chikuma M
14-5931 was used in Flow cytometry/Cell sorting to suggest that AQP9 is required for the development of sensitisation during cutaneous acquired immune responses via regulating neutrophil function.
Thu Oct 22 00:00:00 UTC 2015
CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation.
Journal of neuroinflammation
Wu F,Zhao Y,Jiao T,Shi D,Zhu X,Zhang M,Shi M,Zhou H
14-5931 was used in Flow cytometry/Cell sorting to investigate the roles of CXCR2 and CXCL1 in leukocyte recruitment to the CNS.
Thu May 21 00:00:00 UTC 2015
Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis.
PloS one
Ishizuka M,Miyazaki Y,Masuo M,Suhara K,Tateishi T,Yasui M,Inase N
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of IL-17A in granuloma-forming inflammation in an acute hypersensitivity pneumonitis mouse model.
Thu May 19 00:00:00 UTC 2016
DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.
PLoS genetics
Prochazkova J,Sakaguchi S,Owusu M,Mazouzi A,Wiedner M,Velimezi G,Moder M,Turchinovich G,Hladik A,Gurnhofer E,Hayday A,Behrens A,Knapp S,Kenner L,Ellmeier W,Loizou JI
14-5931 was used in Flow cytometry/Cell sorting to investigate the roles of ATMIN and NBS1, either alone or in combination, in T cells.
Sun Nov 01 00:00:00 UTC 2015
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Oncotarget
Edgington-Mitchell LE,Rautela J,Duivenvoorden HM,Jayatilleke KM,van der Linden WA,Verdoes M,Bogyo M,Parker BS
14-5931 was used in Flow cytometry/Cell sorting to suggest that cysteine protease inhibition is associated with enhanced osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Tue Sep 29 00:00:00 UTC 2015
Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.
Journal of hematology & oncology
Xiao G,Wang X,Sheng J,Lu S,Yu X,Wu JD
14-5931 was used in Flow cytometry/Cell sorting to report a novel mechanism by which soluble MIC imposes an immunosuppressive effect on host immunity and the tumour microenvironment.
Fri Feb 20 00:00:00 UTC 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
14-5931 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 UTC 2014
Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi.
Cell
Deng L,Song J,Gao X,Wang J,Yu H,Chen X,Varki N,Naito-Matsui Y,Galán JE,Varki A
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Dec 04 00:00:00 UTC 2014
Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity.
Gut
Stromnes IM,Brockenbrough JS,Izeradjene K,Carlson MA,Cuevas C,Simmons RM,Greenberg PD,Hingorani SR
14-5931 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to investigate the predominant subsets of immunosuppressive cancer-conditioned myeloid cells that chronicle and shape the progression of pancreas cancer.
Sat Nov 01 00:00:00 UTC 2014
P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice.
Blood
Darbousset R,Delierneux C,Mezouar S,Hego A,Lecut C,Guillaumat I,Riederer MA,Evans RJ,Dignat-George F,Panicot-Dubois L,Oury C,Dubois C
14-5931-82 was used in Immunodepletion to investigate the role of ATP and adenosine in polymorphonuclear neutrophil activation and recruitment at the site of endothelial injury.
Thu Oct 16 00:00:00 UTC 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-5931 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 UTC 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-5931 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 UTC 2014
Factor XIII activity mediates red blood cell retention in venous thrombi.
The Journal of clinical investigation
Aleman MM,Byrnes JR,Wang JG,Tran R,Lam WA,Di Paola J,Mackman N,Degen JL,Flick MJ,Wolberg AS
14-5931 was used in Western Blotting to determine that activity of the transglutaminase factor XIII is critical for red blood cell retention within clots and directly affects thrombus size.
Fri Aug 01 00:00:00 UTC 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-5931 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 UTC 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
14-5931 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 UTC 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-5931 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 UTC 2014
Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
Proceedings of the National Academy of Sciences of the United States of America
Lee WY,Sanz MJ,Wong CH,Hardy PO,Salman-Dilgimen A,Moriarty TJ,Chaconas G,Marques A,Krawetz R,Mody CH,Kubes P
14-5931 was used in Flow cytometry/Cell sorting to demonstrate a novel, critical extravascular invariant natural killer T cell-mediated mechanism of immune surveillance in joints.
Tue Sep 23 00:00:00 UTC 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
14-5931 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 UTC 2014
Macrophages contribute to the cyclic activation of adult hair follicle stem cells.
PLoS biology
Castellana D,Paus R,Perez-Moreno M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Dec 01 00:00:00 UTC 2014
Maresin 1 mitigates LPS-induced acute lung injury in mice.
British journal of pharmacology
Gong J,Wu ZY,Qi H,Chen L,Li HB,Li B,Yao CY,Wang YX,Wu J,Yuan SY,Yao SL,Shang Y
14-5931 was used in Immunohistochemistry to demonstrate that high-dose MaR1 mitigates LPS-induced lung injury in mice by inhibiting neutrophil adhesions and decreasing pro-inflammatory cytokines levels.
Tue Jul 01 00:00:00 UTC 2014
Protecting against post-influenza bacterial pneumonia by increasing phagocyte recruitment and ROS production.
The Journal of infectious diseases
Subramaniam R,Barnes PF,Fletcher K,Boggaram V,Hillberry Z,Neuenschwander P,Shams H
14-5931 was used in Functional assays to define novel mechanisms by which the host can be protected against secondary staphylococcal pneumonia after sub-lethal influenza infection.
Sun Jun 01 00:00:00 UTC 2014
Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregulation of IL-6.
The Journal of investigative dermatology
Kim MH,Gorouhi F,Ramirez S,Granick JL,Byrne BA,Soulika AM,Simon SI,Isseroff RR
14-5931 was used in Flow cytometry/Cell sorting to delplete systemic PMNs in mouse models to evaluate wounding.
Sat Mar 01 00:00:00 UTC 2014
Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.
PLoS pathogens
Kasper KJ,Zeppa JJ,Wakabayashi AT,Xu SX,Mazzuca DM,Welch I,Baroja ML,Kotb M,Cairns E,Cleary PP,Haeryfar SM,McCormick JK
14-5931 was used in Flow cytometry/Cell sorting to study how secreted superantigens contribute to the fitness and evolution of S. pyogenes.
Thu May 01 00:00:00 UTC 2014
Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.
Development (Cambridge, England)
Plosa EJ,Young LR,Gulleman PM,Polosukhin VV,Zaynagetdinov R,Benjamin JT,Im AM,van der Meer R,Gleaves LA,Bulus N,Han W,Prince LS,Blackwell TS,Zent R
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Mon Dec 01 00:00:00 UTC 2014
Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease.
American journal of physiology. Lung cellular and molecular physiology
Lee R,Reese C,Bonner M,Tourkina E,Hajdu Z,Riemer EC,Silver RM,Visconti RP,Hoffman S
14-5931 was used in Immunohistochemistry to compare different methods to delivering bleomycin to the lungs of mice to create an effective model of scleroderma interstitial lung disease.
Tue Apr 15 00:00:00 UTC 2014
Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease.
American journal of physiology. Lung cellular and molecular physiology
Lee R,Reese C,Bonner M,Tourkina E,Hajdu Z,Riemer EC,Silver RM,Visconti RP,Hoffman S
14-5931 was used in Immunohistochemistry to compare different methods to delivering bleomycin to the lungs of mice to create an effective model of scleroderma interstitial lung disease.
Tue Apr 15 00:00:00 UTC 2014
CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer.
Immunology and cell biology
Hart KM,Usherwood EJ,Berwin BL
14-5931 was used in Flow cytometry/Cell sorting to investigate a novel nongranulocytic CX3CR1-negative myeloid population.
Tue Jul 01 00:00:00 UTC 2014
IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K
14-5931 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.
Sat Mar 01 00:00:00 UTC 2014
Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Arina A,Schreiber K,Binder DC,Karrison TG,Liu RB,Schreiber H
14-5931 was used in Flow cytometry/Cell sorting to study the effect of adoptively transferred immune T cells in the presence of MDSCs and TAMs on established tumours, showing that they are eradicated.
Sat Feb 01 00:00:00 UTC 2014
Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ
14-5931 was used in Flow cytometry/Cell sorting to define the expression profile, scavenging activity, and ligand specificity of CCL2 receptors on mouse leukocytes.
Tue Jul 01 00:00:00 UTC 2014
Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Steigedal M,Marstad A,Haug M,Damås JK,Strong RK,Roberts PL,Himpsl SD,Stapleton A,Hooton TM,Mobley HL,Hawn TR,Flo TH
14-5931 was used in Immunofluorescence to demonstrate that LCN2 is secreted by the urinary tract mucosa in response to uropathogenic E. coli challenge.
Mon Dec 15 00:00:00 UTC 2014
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K
14-5931 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.
Sat Mar 15 00:00:00 UTC 2014
Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors.
Journal of immunology (Baltimore, Md. : 1950)
Chernova I,Jones DD,Wilmore JR,Bortnick A,Yucel M,Hershberg U,Allman D
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of subpopulations of bone marrow plasma cells in long-term humoral responses to T cell-dependent Ag.
Sat Nov 15 00:00:00 UTC 2014
Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Liu G,Bi Y,Wang R,Yang H,Zhang Y,Wang X,Liu H,Lu Y,Zhang Z,Chen W,Chu Y,Yang R
14-5931 was used in Flow cytometry/Cell sorting to identify myeloid-derived suppressor cells as essential in providing protection against immune-mediated hepatic injury following rapamycin treatment.
Tue Apr 01 00:00:00 UTC 2014
Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Liu G,Bi Y,Wang R,Yang H,Zhang Y,Wang X,Liu H,Lu Y,Zhang Z,Chen W,Chu Y,Yang R
14-5931 was used in Flow cytometry/Cell sorting to identify myeloid-derived suppressor cells as essential in providing protection against immune-mediated hepatic injury following rapamycin treatment.
Tue Apr 01 00:00:00 UTC 2014
Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Wen Z,Fan L,Li Y,Zou Z,Scott MJ,Xiao G,Li S,Billiar TR,Wilson MA,Shi X,Fan J
14-5931-82 was used in Functional assay to explore a novel function of polymorphonuclear neutrophils regulating AM anti-inflammatory mechanisms involving autophagy.
Sat Nov 01 00:00:00 UTC 2014
Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Sumida H,Yanagida K,Kita Y,Abe J,Matsushima K,Nakamura M,Ishii S,Sato S,Shimizu T
14-5931 was used in Immunohistochemistry to show that CXCR2 and leukotriene B4 receptor BLT1 action plays a role in neutrophil recruitment during imiquimod (IMQ)-induced psoriatic skin lesion development.
Thu May 01 00:00:00 UTC 2014
IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Lajoie S,Lewkowich I,Herman NS,Sproles A,Pesce JT,Wynn TA,Grusby MJ,Hamid Q,Wills-Karp M
14-5931 was used in Flow cytometry/Cell sorting to suggest that IL-21 plays an important role in the allergic diathesis by enhancing Th2 cytokine production through multiple mechanisms.
Tue Jul 01 00:00:00 UTC 2014
Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.
Immunology letters
McMillan SJ,Richards HE,Crocker PR
14-5931 was used in Flow cytometry/Cell sorting to indicate that mechanisms other than ligand-induced apoptosis may be important in siglec-F-dependent suppression of eosinophilia.
Tue Jul 01 00:00:00 UTC 2014
Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2.
Molecular cancer
Doloff JC,Chen CS,Waxman DJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Jun 26 00:00:00 UTC 2014
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
Scientific reports
Hari A,Zhang Y,Tu Z,Detampel P,Stenner M,Ganguly A,Shi Y
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Dec 02 00:00:00 UTC 2014
Protein energy malnutrition increases arginase activity in monocytes and macrophages.
Nutrition & metabolism
Corware K,Yardley V,Mack C,Schuster S,Al-Hassi H,Herath S,Bergin P,Modolell M,Munder M,Müller I,Kropf P
14-5931 was used in Flow cytometry/Cell sorting to explore the effect of protein energy malnutrition on macrophage and monocyte arginase upregulation in response to infection.
Thu Nov 13 00:00:00 UTC 2014
Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by modulating adipogenesis and osteogenesis.
PloS one
Sato F,Miyaoka Y,Miyajima A,Tanaka M
14-5931 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying mesenchymal stromal cell differentiation, showing that oncostatin M maintains the hematopoietic microenvironment in the bone marrow.
Wed May 04 00:00:00 UTC 2016
Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8+ T cell epitopes.
PloS one
Rotem S,Cohen O,Bar-Haim E,Bar-On L,Ehrlich S,Shafferman A
14-5931 was used in Flow cytometry/Cell sorting to demonstrate a novel method for bacterial clearance involving the induction of an immune response to specific pathogenic epitopes.
Wed Sep 10 00:00:00 UTC 2014
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-5931 was used in Flow cytometry/Cell sorting to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 UTC 2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-5931 was used in Flow cytometry/Cell sorting to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 UTC 2013
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Nature
Lukens JR,Vogel P,Johnson GR,Kelliher MA,Iwakura Y,Lamkanfi M,Kanneganti TD
14-5931 was used in Flow cytometry/Cell sorting to investigate how mutations in SHP-1 causes inflammatory disease, showing that RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Thu Jun 13 00:00:00 UTC 2013
T cell factor 1 is required for group 2 innate lymphoid cell generation.
Immunity
Yang Q,Monticelli LA,Saenz SA,Chi AW,Sonnenberg GF,Tang J,De Obaldia ME,Bailis W,Bryson JL,Toscano K,Huang J,Haczku A,Pear WS,Artis D,Bhandoola A
14-5931 was used in Flow cytometry/Cell sorting to study group 2 innate lymphoid cell development.
Thu Apr 18 00:00:00 UTC 2013
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Cell host & microbe
Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW
14-5931 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.
Wed Feb 13 00:00:00 UTC 2013
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-5931 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 UTC 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-5931 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 UTC 2013
The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo.
Blood
Morrison VL,MacPherson M,Savinko T,Lek HS,Prescott A,Fagerholm SC
14-5931 was used in Flow cytometry/Cell sorting to study the implications of a mutated kindlin-3 binding site in β2 integrins in T-cell adhesion and homing responses.
Thu Aug 22 00:00:00 UTC 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
14-5931 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 UTC 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-5931-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 UTC 2013
COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.
Blood
Yoshida A,Kato JY,Nakamae I,Yoneda-Kato N
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of COP1 in tumourigenesis.
Thu Sep 05 00:00:00 UTC 2013
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.
The Journal of clinical investigation
Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM
14-5931 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.
Sun Dec 01 00:00:00 UTC 2013
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
The Journal of experimental medicine
Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N
14-5931 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.
Mon Nov 18 00:00:00 UTC 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-5931 was used in Neutralization experiments to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 UTC 2013
Parathyroid hormone-related protein drives a CD11b+Gr1+ cell-mediated positive feedback loop to support prostate cancer growth.
Cancer research
Park SI,Lee C,Sadler WD,Koh AJ,Jones J,Seo JW,Soki FN,Cho SW,Daignault SD,McCauley LK
14-5931 was used in Immunohistochemistry to investigate whether parathyroid hormone-related protein potentiates CD11b(+)Gr1(+) cells in the bone marrow of prostate tumour hosts.
Fri Nov 15 00:00:00 UTC 2013
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.
Cancer immunology research
Selby MJ,Engelhardt JJ,Quigley M,Henning KA,Chen T,Srinivasan M,Korman AJ
14-5931 was used in Flow cytometry/Cell sorting to analyse the mechanism of action of anti-CTLA-4 antibodies against tumours in greater detail.
Mon Jul 01 00:00:00 UTC 2013
Activator protein-2α mediates carbon monoxide-induced stromal cell-derived factor-1α expression and vascularization in ischemic heart.
Arteriosclerosis, thrombosis, and vascular biology
Lin HH,Chen YH,Chiang MT,Huang PL,Chau LY
14-5931 was used in Immunohistochemistry to demonstrate that AKT-dependent upregulation of AP-2α is essential for CO-induced SDF-1α expression and myocardial repair after ischemic injury.
Mon Apr 01 00:00:00 UTC 2013
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.
PLoS biology
Peine M,Rausch S,Helmstetter C,Fröhlich A,Hegazy AN,Kühl AA,Grevelding CG,Höfer T,Hartmann S,Löhning M
14-5931 was used in Flow cytometry/Cell sorting to characterise Th1/Th2 hybrid cells and assess their role in inflammation.
Thu Mar 06 00:00:00 UTC 2014
Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis.
Oncogene
Shchors K,Nozawa H,Xu J,Rostker F,Swigart-Brown L,Evan G,Hanahan D
14-5931 was used in Immunohistochemistry on frozen tissues to investigate why metalloproteinase inhibitors have been inefficacious in clinical settings.
Thu Jan 24 00:00:00 UTC 2013
MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.
eLife
Heinrichs S,Conover LF,Bueso-Ramos CE,Kilpivaara O,Stevenson K,Neuberg D,Loh ML,Wu WS,Rodig SJ,Garcia-Manero G,Kantarjian HM,Look AT
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that low MYBL2 activity is the underlying cause of the expansion of haematopoietic progenitors in a large fraction of myeloid malignancies.
Tue Jul 16 00:00:00 UTC 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-5931 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 UTC 2013
The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.
Mucosal immunology
Kobayashi A,Donaldson DS,Erridge C,Kanaya T,Williams IR,Ohno H,Mahajan A,Mabbott NA
14-5931 was used in Immunohistochemistry on frozen tissues to investigate the effects of ageing on microfold cells.
Sun Sep 01 00:00:00 UTC 2013
β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation.
European journal of immunology
Yee NK,Hamerman JA
14-5931 was used in Flow cytometry/Cell sorting to show that deficiency in β(2) integrins causes hyperresponsiveness to TLR stimulation.
Fri Mar 01 00:00:00 UTC 2013
Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Fujii W,Ashihara E,Hirai H,Nagahara H,Kajitani N,Fujioka K,Murakami K,Seno T,Yamamoto A,Ishino H,Kohno M,Maekawa T,Kawahito Y
14-5931 was used in Flow cytometry/Cell sorting to clarify that myeloid-derived suppressor cells are crucial in regulating the proinflammatory immune response in mouse collagen-induced arthritis.
Thu Aug 01 00:00:00 UTC 2013
Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Deguchi A,Tomita T,Omori T,Komatsu A,Ohto U,Takahashi S,Tanimura N,Akashi-Takamura S,Miyake K,Maru Y
14-5931 was used in Flow cytometry/Cell sorting to investigate how SAA3 directly binds MD-2 and activates the MyD88-dependent TLR4/MD-2 pathway.
Thu Aug 15 00:00:00 UTC 2013
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
Molecular and cellular biology
Ren X,Shah TA,Ustiyan V,Zhang Y,Shinn J,Chen G,Whitsett JA,Kalin TV,Kalinichenko VV
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of transcriptional control of goblet cell differentiation and mucus hyperproduction, showing that FOXM1 promotes allergen-induced metaplasia and pulmonary inflammation.
Tue Jan 01 00:00:00 UTC 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-5931 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 UTC 2013
SAP modulates B cell functions in a genetic background-dependent manner.
Immunology letters
Detre C,Yigit B,Keszei M,Castro W,Magelky EM,Terhorst C
14-5931 was used in Flow cytometry/Cell sorting to investigate the mechanism by which SLAM-associated protein modulates B cell functions.
Sat Jun 01 00:00:00 UTC 2013
Attachment of flexible heparin chains to gelatin scaffolds improves endothelial cell infiltration.
Tissue engineering. Part A
Leijon J,Carlsson F,Brännström J,Sanchez J,Larsson R,Nilsson B,Magnusson PU,Rosenquist M
14-5931 was used in Immunohistochemistry to examine the role of surface modification of gelatin scaffolds in promoting endothelial cell infiltration through attachment of heparin chains.
Sat Jun 01 00:00:00 UTC 2013
CD38 controls the innate immune response against Listeria monocytogenes.
Infection and immunity
Lischke T,Heesch K,Schumacher V,Schneider M,Haag F,Koch-Nolte F,Mittrücker HW
14-5931 was used in Flow cytometry/Cell sorting to evaluate the key enzymes governing the innate immune response.
Fri Nov 01 00:00:00 UTC 2013
Cdc42 promotes host defenses against fatal infection.
Infection and immunity
Lee K,Boyd KL,Parekh DV,Kehl-Fie TE,Baldwin HS,Brakebusch C,Skaar EP,Boothby M,Zent R
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of Cdc42-dependent signalling in fibroblasts, showing that it promotes host defences against fatal infection.
Thu Aug 01 00:00:00 UTC 2013
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Developmental biology
Bai X,Trowbridge JJ,Riley E,Lee JA,DiBiase A,Kaartinen VM,Orkin SH,Zon LI
14-5931 was used in Flow cytometry/Cell sorting to study the role of TIF1γ in murine erythropoiesis and to assess its function in other blood lineages.
Tue Jan 15 00:00:00 UTC 2013
R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea.
Nature communications
Papapietro O,Teatero S,Thanabalasuriar A,Yuki KE,Diez E,Zhu L,Kang E,Dhillon S,Muise AM,Durocher Y,Marcinkiewicz MM,Malo D,Gruenheid S
14-5931 was used in Immunocytochemistry to demonstrate a previously unknown role of R-spondins and Wnt signalling in susceptibility to infectious diarrhoea and identify R-spondin2 as a key molecular link between infection and intestinal homoeostasis.
Mon Dec 30 00:00:00 UTC 2013
R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea.
Nature communications
Papapietro O,Teatero S,Thanabalasuriar A,Yuki KE,Diez E,Zhu L,Kang E,Dhillon S,Muise AM,Durocher Y,Marcinkiewicz MM,Malo D,Gruenheid S
14-5931 was used in Immunocytochemistry to demonstrate a previously unknown role of R-spondins and Wnt signalling in susceptibility to infectious diarrhoea and identify R-spondin2 as a key molecular link between infection and intestinal homoeostasis.
Mon Dec 30 00:00:00 UTC 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Jul 19 00:00:00 UTC 2013
Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.
PloS one
Stamm C,Barthelmann J,Kunz N,Toellner KM,Westermann J,Kalies K
14-5931 was used in Immunofluorescence to investigate how B cells might be promising targets in order to therapeutically modulate the T cell response.
Thu Apr 24 00:00:00 UTC 2014
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
14-5931 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 UTC 2013
A New Murine Model for Gastrointestinal Anthrax Infection.
PloS one
Xie T,Sun C,Uslu K,Auth RD,Fang H,Ouyang W,Frucht DM
14-5931 was used in Immunofluorescence to show that antibiotic treatment of infected animals 24 h following high-dose bacterial gavage protected all animals, demonstrating the utility of this animal model in evaluating potential therapeutics.
Fri Oct 13 00:00:00 UTC 2017
Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection.
PloS one
Obregón-Henao A,Henao-Tamayo M,Orme IM,Ordway DJ
14-5931 was used in Immunohistochemistry to compare the bacterial burden, lung pathology and Gr1(int)CD11b(+) myeloid-derived suppressor cell immune responses in M. tuberculosis infected mice.
Fri Jun 20 00:00:00 UTC 2014
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.
Immunity
Oyoshi MK,He R,Li Y,Mondal S,Yoon J,Afshar R,Chen M,Lee DM,Luo HR,Luster AD,Cho JS,Miller LS,Larson A,Murphy GF,Geha RS
14-5931 was used in Functional assays to demonstrate that scratching of human skin and tape stripping of mouse skin cause neutrophil influx.
Fri Oct 19 00:00:00 UTC 2012
Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.
Immunity
Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK
14-5931 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.
Fri Apr 20 00:00:00 UTC 2012
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-5931 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 UTC 2012
Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation.
Blood
Darbousset R,Thomas GM,Mezouar S,Frère C,Bonier R,Mackman N,Renné T,Dignat-George F,Dubois C,Panicot-Dubois L
14-5931-82 was used in Immunodepletion to show that the interaction of neutrophils with endothelial cells precedes platelet accumulation in initiating arterial thrombosis in injured vessels.
Thu Sep 06 00:00:00 UTC 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of kruppel-like factor 7 in hematopoietic stem and progenitor cell function.
Thu Oct 11 00:00:00 UTC 2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Blood
Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K
14-5931 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.
Thu Jun 14 00:00:00 UTC 2012
Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
The Journal of experimental medicine
Boulard O,Kirchberger S,Royston DJ,Maloy KJ,Powrie FM
14-5931 was used in Flow cytometry/Cell sorting to investigate the genetic factors influencing the progression from Helicobacter hepaticus-driven colitis to tumorigenesis in a mouse model.
Mon Jul 02 00:00:00 UTC 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-5931 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 UTC 2012
Leukocyte-dependent responses of the microvasculature to chronic angiotensin II exposure.
Hypertension (Dallas, Tex. : 1979)
Yildirim A,Russell J,Yan LS,Senchenkova EY,Granger DN
14-5931 was used in Functional assays to study the contributions of angiotensin II type 1 receptors to the recruitment of leukocytes and platelets, and reactive oxygen species production in venules during chronic infusion of angiotensin II.
Sat Dec 01 00:00:00 UTC 2012
Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Nakayama Y,Bromberg JS
14-5931 was used in Flow cytometry/Cell sorting to study the effect of LTβRIg treatment in a murine cardiac allograft model.
Sat Sep 01 00:00:00 UTC 2012
ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment.
Journal of leukocyte biology
Long C,Hosseinkhani MR,Wang Y,Sriramarao P,Walcheck B
14-5931 was used in Flow cytometry/Cell sorting to study how impaired L-selectin shedding is a key mechanism underlying early neutrophil recruitment in conditional ADAM17 knockout mice during bacterial infection.
Sat Sep 01 00:00:00 UTC 2012
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
Journal of leukocyte biology
Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E
14-5931 was used in Immunohistochemistry to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.
Thu Nov 01 00:00:00 UTC 2012
NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.
Journal of immunology (Baltimore, Md. : 1950)
Häcker H,Chi L,Rehg JE,Redecke V
14-5931 was used in Flow cytometry/Cell sorting to show that NF-κB-inducing kinase activity in non-haematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease.
Tue May 01 00:00:00 UTC 2012
Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Mizutani N,Goshima H,Nabe T,Yoshino S
14-5931 was used in Neutralization experiments to investigate the relationship between IL-17 and IgE-mediated asthmatic responses.
Fri Jun 01 00:00:00 UTC 2012
Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950)
Boettcher S,Ziegler P,Schmid MA,Takizawa H,van Rooijen N,Kopf M,Heikenwalder M,Manz MG
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that TLR4-expressing nonhematopoietic cells are indispensable for LPS-induced, G-CSF-mediated myelopoietic responses.
Fri Jun 15 00:00:00 UTC 2012
IL-17A differentially regulates corneal vascular endothelial growth factor (VEGF)-A and soluble VEGF receptor 1 expression and promotes corneal angiogenesis after herpes simplex virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Suryawanshi A,Veiga-Parga T,Reddy PB,Rajasagi NK,Rouse BT
14-5931 was used in Immunofluorescence to uncover a useful approach to inhibiting CV and the control of an ocular lesion that is an important cause of human blindness.
Sun Apr 01 00:00:00 UTC 2012
Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Sawaguchi M,Tanaka S,Nakatani Y,Harada Y,Mukai K,Matsunaga Y,Ishiwata K,Oboki K,Kambayashi T,Watanabe N,Karasuyama H,Nakae S,Inoue H,Kubo M
14-5931 was used in Flow cytometry/Cell sorting to demonstrate an indispensable role for MCs as effector cells in AHR.
Wed Feb 15 00:00:00 UTC 2012
Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-γ-mediated skin inflammation.
The Journal of pharmacology and experimental therapeutics
Hsieh CY,Chen CL,Tsai CC,Huang WC,Tseng PC,Lin YS,Chen SH,Wong TW,Choi PC,Lin CF
14-5931 was used in Functional assays to examine the effects of inhibiting Glycogen synthase kinase-3, on 12-O-tetradecanoylphorbol-13-acetate-mediated skin inflammation.
Mon Oct 01 00:00:00 UTC 2012
INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury.
American journal of physiology. Renal physiology
Lee DH,Wolstein JM,Pudasaini B,Plotkin M
14-5931 was used in Neutralization experiments to investigate the molecular mechanisms that lead to tubular atrophy, capillary loss, and fibrosis following acute kidney injury.
Sun Jan 01 00:00:00 UTC 2012
Differential gene expression in mice infected with distinct Toxoplasma strains.
Infection and immunity
Hill RD,Gouffon JS,Saxton AM,Su C
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Thu Mar 01 00:00:00 UTC 2012
Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.
Infection and immunity
Kanistanon D,Powell DA,Hajjar AM,Pelletier MR,Cohen IE,Way SS,Skerrett SJ,Wang X,Raetz CR,Ernst RK
14-5931 was used in Flow cytometry/Cell sorting to study the pathogenic effects of LPS modifications at the lipid A component of a Francisella novicida mutant.
Thu Mar 01 00:00:00 UTC 2012
A model of GAG/MIP-2/CXCR2 interfaces and its functional effects.
Biochemistry
Rajasekaran D,Keeler C,Syed MA,Jones MC,Harrison JK,Wu D,Bhandari V,Hodsdon ME,Lolis EJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Jul 17 00:00:00 UTC 2012
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
14-5931 was used in Immunohistochemistry on frozen tissues to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.
Thu Mar 28 00:00:00 UTC 2013
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
14-5931 was used in Immunohistochemistry on frozen tissues to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.
Thu Mar 28 00:00:00 UTC 2013
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
14-5931 was used in Immunohistochemistry on frozen tissues to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.
Thu Mar 28 00:00:00 UTC 2013
Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.
PloS one
Gentschev I,Adelfinger M,Josupeit R,Rudolph S,Ehrig K,Donat U,Weibel S,Chen NG,Yu YA,Zhang Q,Heisig M,Thamm D,Stritzker J,Macneill A,Szalay AA
14-5931 was used in Immunohistochemistry on frozen tissues to describe the establishment of an in vivo model of canine soft tissue sarcoma, allowing preclinical evaluation of oncolytic vaccinia virus for therapy.
Thu Sep 20 00:00:00 UTC 2012
Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.
PloS one
Gentschev I,Adelfinger M,Josupeit R,Rudolph S,Ehrig K,Donat U,Weibel S,Chen NG,Yu YA,Zhang Q,Heisig M,Thamm D,Stritzker J,Macneill A,Szalay AA
14-5931 was used in Immunohistochemistry on frozen tissues to describe the establishment of an in vivo model of canine soft tissue sarcoma, allowing preclinical evaluation of oncolytic vaccinia virus for therapy.
Thu Sep 20 00:00:00 UTC 2012
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Feb 25 00:00:00 UTC 2013
Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment.
Cell communication and signaling : CCS
Wiechert L,Németh J,Pusterla T,Bauer C,De Ponti A,Manthey S,Marhenke S,Vogel A,Klingmüller U,Hess J,Angel P
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunohistochemistry
Sat Dec 15 00:00:00 UTC 2012
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
14-5931 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 UTC 2012
Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.
PloS one
Menning A,Walter A,Rudolph M,Gashaw I,Fritzemeier KH,Roese L
14-5931 was used in Functional assays to investigate mechanisms underlying pathogenesis of menstrual disorders, showing that granulocytes and vascularisation regulate uterine bleeding and tissue remodelling.
Thu Jan 10 00:00:00 UTC 2013
An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes.
PloS one
Pais R,Bhowmick S,Chattopadhyay S,Lemire Y,Sharafieh R,Yadav R,O'Rourke J,Cone RE
14-5931 was used in Flow cytometry/Cell sorting to further suggest that anterior chamber-associated immune deviation is initiated as the result of a mild proinflammatory response to intracameral injection.
Wed May 01 00:00:00 UTC 2013
Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury.
Circulation
Kawaguchi M,Takahashi M,Hata T,Kashima Y,Usui F,Morimoto H,Izawa A,Takahashi Y,Masumoto J,Koyama J,Hongo M,Noda T,Nakayama J,Sagara J,Taniguchi S,Ikeda U
14-5931 was used in Immunohistochemistry to demonstrate the molecular basis for the initial inflammatory response after myocardial ischemia/reperfusion injury.
Tue Feb 15 00:00:00 UTC 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-5931 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 UTC 2011
A novel role for IL-22R1 as a driver of inflammation.
Blood
Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA
14-5931 was used in Flow cytometry/Cell sorting to document a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in ALK(+)ALCL.
Thu Jan 13 00:00:00 UTC 2011
Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice.
Circulation research
Wan W,Lim JK,Lionakis MS,Rivollier A,McDermott DH,Kelsall BL,Farber JM,Murphy PM
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Aug 05 00:00:00 UTC 2011
Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
The Journal of clinical investigation
Horikawa M,Minard-Colin V,Matsushita T,Tedder TF
14-5931 was used in Flow cytometry/Cell sorting to investigate whether heterogeneity in endogenous tissue CD20+ B cell depletion influences in vivo lymphoma therapy, showing that production of IL-10 inhibits lymphoma depletion.
Tue Nov 01 00:00:00 UTC 2011
Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
The Journal of clinical investigation
Horikawa M,Minard-Colin V,Matsushita T,Tedder TF
14-5931 was used in Flow cytometry/Cell sorting to investigate whether heterogeneity in endogenous tissue CD20+ B cell depletion influences in vivo lymphoma therapy, showing that production of IL-10 inhibits lymphoma depletion.
Tue Nov 01 00:00:00 UTC 2011
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
The Journal of clinical investigation
Sindrilaru A,Peters T,Wieschalka S,Baican C,Baican A,Peter H,Hainzl A,Schatz S,Qi Y,Schlecht A,Weiss JM,Wlaschek M,Sunderkötter C,Scharffetter-Kochanek K
14-5931 was used in Immunofluorescence to study human subjects with chronic venous leg ulcers and devise a human and mouse disease model for macrophage-driven chronic inflammation.
Tue Mar 01 00:00:00 UTC 2011
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.
The Journal of clinical investigation
Cheung R,Shen F,Phillips JH,McGeachy MJ,Cua DJ,Heyworth PG,Pierce RH
14-5931 was used in Flow cytometry/Cell sorting to identify the MDL-1/Syk/PI3K/Akt/eNOS pathway as a potential new target for the prevention of the progression of SIRS to shock.
Tue Nov 01 00:00:00 UTC 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
14-5931 was used in Flow cytometry/Cell sorting to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.
Mon Mar 14 00:00:00 UTC 2011
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.
Cancer research
Fujita M,Kohanbash G,Fellows-Mayle W,Hamilton RL,Komohara Y,Decker SA,Ohlfest JR,Okada H
14-5931 was used in Flow cytometry/Cell sorting to show that the COX-2 pathway promotes gliomagenesis by supporting systemic development of MDSCs and their accumulation in the TME.
Fri Apr 01 00:00:00 UTC 2011
Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.
The American journal of pathology
Nesterovitch AB,Szanto S,Gonda A,Bardos T,Kis-Toth K,Adarichev VA,Olasz K,Ghassemi-Najad S,Hoffman MD,Tharp MD,Mikecz K,Glant TT
14-5931 was used in Immunohistochemistry to show that insertion of a B2 element in exon 6 of the Ptpn6 gene (Shp-1) leads to an autoinflammatory disease with similarities to neutrophilic dermatoses in humans.
Fri Apr 01 00:00:00 UTC 2011
MMP9 is protective against lethal inflammatory mass lesions in the mouse colon.
Disease models & mechanisms
Hald A,Rønø B,Melander MC,Ding M,Holck S,Lund LR
14-5931 was used in Immunohistochemistry on paraffin embedded tissues to investigate the vital protective role of MMP9, in the absence of Plasminogen, against lethal inflammatory mass lesions in the mouse colon..
Tue Mar 01 00:00:00 UTC 2011
High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response.
Laboratory investigation; a journal of technical methods and pathology
Duan L,Wang CY,Chen J,Gong Q,Zhu P,Zheng F,Tan Z,Gong F,Fang M
14-5931 was used in Immunohistochemistry to investigate the role of HMGB1 in cadiac allograft acute rejection, showing that it promotes rejection by enhancing IL-6-dependent Th17 alloreactive response.
Sat Jan 01 00:00:00 UTC 2011
DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity.
Journal of immunology (Baltimore, Md. : 1950)
Guerriero JL,Ditsworth D,Catanzaro JM,Sabino G,Furie MB,Kew RR,Crawford HC,Zong WX
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Tue Mar 15 00:00:00 UTC 2011
Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Qu P,Yan C,Blum JS,Kapur R,Du H
14-5931-82 was used in Flow Cytometry to study how myeloid cell lysosomal acid lipase controls normal haematopoietic cell development and balances immunosuppression and inflammation.
Sat Oct 01 00:00:00 UTC 2011
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hasegawa M,Yamazaki T,Kamada N,Tawaratsumida K,Kim YG,Núñez G,Inohara N
14-5931 was used in Neutralization experiments to investigate how Nod1 regulates host susceptibility to C. difficile, and how Nod1-mediated neutrophil recruitment may be an important immune response against the pathogen.
Fri Apr 15 00:00:00 UTC 2011
Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates.
Molecular pharmaceutics
Ren K,Purdue PE,Burton L,Quan LD,Fehringer EV,Thiele GM,Goldring SR,Wang D
14-5931 was used in Immunohistochemistry on frozen tissues to develop methods for early detection and intervention prior to joint implant failure.
Mon Aug 01 00:00:00 UTC 2011
Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates.
Molecular pharmaceutics
Ren K,Purdue PE,Burton L,Quan LD,Fehringer EV,Thiele GM,Goldring SR,Wang D
14-5931 was used in Immunohistochemistry on frozen tissues to develop methods for early detection and intervention prior to joint implant failure.
Mon Aug 01 00:00:00 UTC 2011
Control of methicillin resistant Staphylococcus aureus infection utilizing a novel immunostimulatory peptide.
Vaccine
Sheen TR,Cavaco CK,Ebrahimi CM,Thoman ML,Sanderson SD,Morgan EL,Doran KS
14-5931 was used in a Functional assay to study the use of EP67 in the induction of host innate immunity as a therapeutic method of reducing community-acquired methicillin-resistant Staphylococcus aureus infections.
Fri Dec 09 00:00:00 UTC 2011
The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation.
PloS one
Jenne CN,Wong CH,Petri B,Kubes P
14-5931 was used in Immunofluorescence to describe two new methods for the intravital visualisation of platelet biology.
Fri Feb 03 00:00:00 UTC 2012
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-5931 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 UTC 2011
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Immunity
Staudt V,Bothur E,Klein M,Lingnau K,Reuter S,Grebe N,Gerlitzki B,Hoffmann M,Ulges A,Taube C,Dehzad N,Becker M,Stassen M,Steinborn A,Lohoff M,Schild H,Schmitt E,Bopp T
14-5931 was used in Flow cytometry/Cell sorting to demonstrate the immunological effects of interferon-regulatory factor 4 (IRF4) deficiency on CD4(+) T cell polarsiation.
Fri Aug 27 00:00:00 UTC 2010
In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice.
Gastroenterology
Hunter MM,Wang A,Parhar KS,Johnston MJ,Van Rooijen N,Beck PL,McKay DM
14-5931 was used in Immunoprecipitation to investigate whether alternatively activated macrophages have anticolitic effects.
Thu Apr 01 00:00:00 UTC 2010
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-5931 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 UTC 2010
Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency.
The American journal of pathology
Choi J,Curtis SJ,Roy DM,Flesken-Nikitin A,Nikitin AY
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Nov 01 00:00:00 UTC 2010
Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency.
The American journal of pathology
Choi J,Curtis SJ,Roy DM,Flesken-Nikitin A,Nikitin AY
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Nov 01 00:00:00 UTC 2010
Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.
The American journal of pathology
Yoshida H,Russell J,Senchenkova EY,Almeida Paula LD,Granger DN
14-5931-82 was used in In vivo experiments to evaluate the role of interleukin-1β in enhanced extra-intestinal thrombosis observed in mice with dextran sodium sulfate-induced colitis.
Wed Dec 01 00:00:00 UTC 2010
CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway.
The American journal of pathology
Dalli J,Rosignoli G,Hayhoe RP,Edelman A,Perretti M
14-5931 was used in Flow cytometry/Cell sorting to provide an important insight into the mechanism underlying the inflammatory disease associated with CFTR inhibition.
Thu Jul 01 00:00:00 UTC 2010
Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Henry T,Kirimanjeswara GS,Ruby T,Jones JW,Peng K,Perret M,Ho L,Sauer JD,Iwakura Y,Metzger DW,Monack DM
14-5931 was used in Flow cytometry/Cell sorting to determine that type I IFN signalling might contribute to the resistance of mice to infection with other intracellular bacteria.
Thu Apr 01 00:00:00 UTC 2010
BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Smith IA,Knezevic BR,Ammann JU,Rhodes DA,Aw D,Palmer DB,Mather IH,Trowsdale J
14-5931 was used in Flow cytometry/Cell sorting to confirm a coinhibitory role for mouse BTN1A1.
Thu Apr 01 00:00:00 UTC 2010
In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Ly LV,Baghat A,Versluis M,Jordanova ES,Luyten GP,van Rooijen N,van Hall T,van der Velden PA,Jager MJ
14-5931 was used in Immunohistochemistry to demonstrate that tumor-associated macrophages are directly involved in tumor outgrowth of intraocular melanoma.
Wed Sep 15 00:00:00 UTC 2010
Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Dufton N,Hannon R,Brancaleone V,Dalli J,Patel HB,Gray M,D'Acquisto F,Buckingham JC,Perretti M,Flower RJ
14-5931 was used in Flow cytometry/Cell sorting to conclude that Fpr2 is an anti-inflammatory receptor that serves varied regulatory functions during the host defense response.
Mon Mar 01 00:00:00 UTC 2010
Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4.
Journal of immunology (Baltimore, Md. : 1950)
Zhang B,Jia H,Liu J,Yang Z,Jiang T,Tang K,Li D,Huang C,Ma J,Shen GX,Ye D,Huang B
14-5931 was used in Functional assays to show that Tregs play opposite roles in tumor development: promoting early and inhibiting late tumor growth.
Wed Dec 15 00:00:00 UTC 2010
IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.
International immunology
Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN
14-5931 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.
Thu Apr 01 00:00:00 UTC 2010
The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.
Cellular microbiology
Durand EA,Maldonado-Arocho FJ,Castillo C,Walsh RL,Mecsas J
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Sun Aug 01 00:00:00 UTC 2010
The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.
Cellular microbiology
Durand EA,Maldonado-Arocho FJ,Castillo C,Walsh RL,Mecsas J
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Immunofluorescence
Sun Aug 01 00:00:00 UTC 2010
Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model.
PloS one
Yang Z,Zhang B,Li D,Lv M,Huang C,Shen GX,Huang B
14-5931 was used in Functional assays to delineate the mechanisms underlying the exacerbation of inflammation in the tumour microenvironment by mast cells.
Wed Jan 27 00:00:00 UTC 2010
S100A proteins in the pathogenesis of experimental corneal neovascularization.
Molecular vision
Li C,Zhang F,Wang Y
14-5931-82 was used in Immunodepletion to determine that S100A proteins are involved in the inflammatory corneal neovascularisation model.
Sun Oct 31 00:00:00 UTC 2010
PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation.
Cell host & microbe
Saha S,Qi J,Wang S,Wang M,Li X,Kim YG,Núñez G,Gupta D,Dziarski R
14-5931 was used in Western Blotting to demonstrate that PGRPs, Nod2, and TLR4, representing three different types of pattern-recognition molecules, play interdependent in vivo roles in local inflammation.
Thu Feb 19 00:00:00 UTC 2009
Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.
American journal of respiratory and critical care medicine
Wilson RH,Whitehead GS,Nakano H,Free ME,Kolls JK,Cook DN
14-5931 was used in Functional assays to investigate whether allergic sensitisation through the airway elicits immune responses qualitatively different than those arising in the peritoneum.
Thu Oct 15 00:00:00 UTC 2009
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
Blood
Van Ziffle JA,Lowell CA
14-5931 was used in Flow cytometry/Cell sorting to indicate that loss of Syk kinase-mediated integrin signalling impairs leukocyte activation, leading to reduced host defense responses.
Thu Nov 26 00:00:00 UTC 2009
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood
Guibal FC,Alberich-Jorda M,Hirai H,Ebralidze A,Levantini E,Di Ruscio A,Zhang P,Santana-Lemos BA,Neuberg D,Wagers AJ,Rego EM,Tenen DG
14-5931 was used in Flow cytometry/Cell sorting to provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can propagate the disease.
Thu Dec 24 00:00:00 UTC 2009
The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans.
The Journal of clinical investigation
Charles KA,Kulbe H,Soper R,Escorcio-Correia M,Lawrence T,Schultheis A,Chakravarty P,Thompson RG,Kollias G,Smyth JF,Balkwill FR,Hagemann T
14-5931 was used in Functional assays to demonstrate that chronic production of TNF-α in the tumor microenvironment increases myeloid cell recruitment in an IL-17-dependent manner.
Thu Oct 01 00:00:00 UTC 2009
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.
The EMBO journal
Qian F,Deng J,Cheng N,Welch EJ,Zhang Y,Malik AB,Flavell RA,Dong C,Ye RD
14-5931 was used in functional experiments to show the role of MKP5 in restraining p38 MAPK-mediated neutrophil oxidant production, thereby preventing LPS-induced vascular injury in mice.
Wed Oct 07 00:00:00 UTC 2009
Migratory and antigen presentation functions of IFN-producing killer dendritic cells.
Cancer research
Himoudi N,Yan M,Bouma G,Morgenstern D,Wallace R,Seddon B,Buddle J,Eddaoudi A,Howe SJ,Cooper N,Anderson J
14-5931 was used in Flow cytometry/Cell sorting to study how BM-IKDCs are capable of cytotoxic killing of tumour targets, and also of potent antigen presentation after encountering antigen in the context of a viable target cell.
Sat Aug 15 00:00:00 UTC 2009
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
PLoS biology
Sabnis AJ,Cheung LS,Dail M,Kang HC,Santaguida M,Hermiston ML,Passegué E,Shannon K,Braun BS
14-5931 was used in Flow cytometry/Cell sorting to conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice.
Tue Mar 17 00:00:00 UTC 2009
Effect of IL-10 on neutrophil recruitment and survival after Pseudomonas aeruginosa challenge.
American journal of respiratory cell and molecular biology
Sun L,Guo RF,Newstead MW,Standiford TJ,Macariola DR,Shanley TP
14-5931 was used in Immunodepletion to indicate that early neutrophil recruitment is important for combating bacterial infection.
Wed Jul 01 00:00:00 UTC 2009
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
14-5931 was used in Flow cytometry/Cell sorting to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 UTC 2009
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.
PLoS pathogens
Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.
Wed Apr 01 00:00:00 UTC 2009
SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages.
The American journal of pathology
Kirby AC,Beattie L,Maroof A,van Rooijen N,Kaye PM
14-5931 was used in Flow cytometry/Cell sorting to show the protective activity of SIGNR1(+) marginal zone macrophages can be compensated for by activated red pulp macrophages.
Tue Sep 01 00:00:00 UTC 2009
Innate immune cells induce hemorrhage in tumors during thrombocytopenia.
The American journal of pathology
Ho-Tin-Noé B,Carbo C,Demers M,Cifuni SM,Goerge T,Wagner DD
14-5931 was used in Flow cytometry/Cell sorting to show that platelets counteract tumor-associated inflammation and that the absence of this platelet function elicits vascular injuries by tumor-infiltrating innate immune cells.
Thu Oct 01 00:00:00 UTC 2009
Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Zhou H,Andonegui G,Wong CH,Kubes P
14-5931 was used in in vivo experiments to demonstrate that direct endothelial activation is sufficient to mediate leukocyte rolling and adhesion in cerebral microvessels.
Thu Oct 15 00:00:00 UTC 2009
Inflammation recapitulates the ontogeny of lymphoid stromal cells.
Journal of immunology (Baltimore, Md. : 1950)
Peduto L,Dulauroy S,Lochner M,Späth GF,Morales MA,Cumano A,Eberl G
14-5931 was used in Functional assays to show that LS cells are both programmed during ontogeny and reinduced during inflammation.
Fri May 01 00:00:00 UTC 2009
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Cellular immunology
Drage MG,Pecora ND,Hise AG,Febbraio M,Silverstein RL,Golenbock DT,Boom WH,Harding CV
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Fri Jun 12 00:00:00 UTC 2009
Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway.
Infection and immunity
Bulut Y,Shimada K,Wong MH,Chen S,Gray P,Alsabeh R,Doherty TM,Crother TR,Arditi M
14-5931 was used in Flow cytometry/Cell sorting to suggest that cHSP60 causes lung inflammation and dendritic cell activation via Toll-like receptor 4 and MyD88.
Wed Jul 01 00:00:00 UTC 2009
Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model.
FEMS immunology and medical microbiology
Shimazaki K,Chan AM,Moniz RJ,Wadehra M,Nagy A,Coulam CP,Mareninov S,Lepin EM,Wu AM,Kelly KA,Braun J,Gordon LK
14-5931 was used in Flow cytometry/Cell sorting to support EMP2 as a potential preventative and therapeutic target for genital chlamydial infection in vivo.
Sun Mar 01 00:00:00 UTC 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
14-5931 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 UTC 2009
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Nature medicine
Nasr R,Guillemin MC,Ferhi O,Soilihi H,Peres L,Berthier C,Rousselot P,Robledo-Sarmiento M,Lallemand-Breitenbach V,Gourmel B,Vitoux D,Pandolfi PP,Rochette-Egly C,Zhu J,de Thé H
14-5931 was used in Flow cytometry/Cell sorting to investigate how retinoic acid also triggers growth arrest of leukemia-initiating cells (LICs) ex vivo and their clearance in PML-RARA mouse APL in vivo.
Mon Dec 01 00:00:00 UTC 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5931-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5931-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles.
Blood
Dalli J,Norling LV,Renshaw D,Cooper D,Leung KY,Perretti M
14-5931-82 was used in Immunocytochemistry to study whether biologically active anti-inflammatory protein annexin 1 could be present in polymorphonuclear leukocyte-derived microparticles.
Mon Sep 15 00:00:00 UTC 2008
The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease.
The Journal of experimental medicine
Carlson T,Kroenke M,Rao P,Lane TE,Segal B
14-5931 was used in Flow cytometry/Cell sorting to demonstrate that ELR(+) CXC chemokines and CXCR2-expressing polymorphonuclear leukocytes are required for the development of experimental autoimmune encephalomyelitis.
Mon Apr 14 00:00:00 UTC 2008
Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.
The Journal of experimental medicine
McDonald B,McAvoy EF,Lam F,Gill V,de la Motte C,Savani RC,Kubes P
14-5931 was used in Immunocytochemistry-immunoflourescence to identify that hyaluronan is disproportionately expressed in the liver compared to other organs under basal and inflammatory conditions.
Mon Apr 14 00:00:00 UTC 2008
Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.
The Journal of experimental medicine
McDonald B,McAvoy EF,Lam F,Gill V,de la Motte C,Savani RC,Kubes P
14-5931 was used in Immunocytochemistry-immunoflourescence to identify that hyaluronan is disproportionately expressed in the liver compared to other organs under basal and inflammatory conditions.
Mon Apr 14 00:00:00 UTC 2008
Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice.
The American journal of pathology
Ward PP,Mendoza-Meneses M,Park PW,Conneely OM
14-5931 was used in Flow cytometry/Cell sorting to indicate that although LF deficiency alone is not a primary cause of the defects associated with SGD, this protein does play an immunomodulatory role in the oxidative burst response of neutrophils.
Tue Apr 01 00:00:00 UTC 2008
Unique receptor repertoire in mouse uterine NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F
14-5931-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.
Sat Nov 01 00:00:00 UTC 2008
Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota.
Infection and immunity
Lawley TD,Bouley DM,Hoy YE,Gerke C,Relman DA,Monack DM
Tue Jan 01 00:00:00 UTC 2008
Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota.
Infection and immunity
Lawley TD,Bouley DM,Hoy YE,Gerke C,Relman DA,Monack DM
Tue Jan 01 00:00:00 UTC 2008
Pseudomonas aeruginosa induces localized immunosuppression during pneumonia.
Infection and immunity
Diaz MH,Shaver CM,King JD,Musunuri S,Kazzaz JA,Hauser AR
14-5931 was used in Functional assays to show that Pseudomonas aeruginosa interferes with the ability of recruited phagocytes to eradicate bacteria from the lung.
Wed Oct 01 00:00:00 UTC 2008
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
PloS one
Banerjee R,Mosley RL,Reynolds AD,Dhar A,Jackson-Lewis V,Gordon PH,Przedborski S,Gendelman HE
14-5931 was used in Immunohistochemistry on frozen tissues to investigate the role of T cell immunity in human G93A SOD1 Tg mice and in ALS patients.
Wed Jul 23 00:00:00 UTC 2008
Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice.
Blood
Chappaz S,Flueck L,Farr AG,Rolink AG,Finke D
14-5931 was used in Flow cytometry/Cell sorting to investigate the role of TSLP in lymphopoiesis and immune cell development in IL-7-deficient mice.
Sat Dec 01 00:00:00 UTC 2007
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation
Humblet-Baron S,Sather B,Anover S,Becker-Herman S,Kasprowicz DJ,Khim S,Nguyen T,Hudkins-Loya K,Alpers CE,Ziegler SF,Ochs H,Torgerson T,Campbell DJ,Rawlings DJ
14-5931 was used in Flow cytometry/Cell sorting to investigate whether alterations in Treg function might explain Wiskott-Aldrich syndrome pathology, showing that WASp is required for Treg homeostasis.
Thu Feb 01 00:00:00 UTC 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 UTC 2007
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Journal of leukocyte biology
Sasmono RT,Ehrnsperger A,Cronau SL,Ravasi T,Kandane R,Hickey MJ,Cook AD,Himes SR,Hamilton JA,Hume DA
Sun Jul 01 00:00:00 UTC 2007
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Journal of leukocyte biology
Sasmono RT,Ehrnsperger A,Cronau SL,Ravasi T,Kandane R,Hickey MJ,Cook AD,Himes SR,Hamilton JA,Hume DA
Sun Jul 01 00:00:00 UTC 2007
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Journal of leukocyte biology
Sasmono RT,Ehrnsperger A,Cronau SL,Ravasi T,Kandane R,Hickey MJ,Cook AD,Himes SR,Hamilton JA,Hume DA
Sun Jul 01 00:00:00 UTC 2007
Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.
Molecular and cellular biology
Tenno M,Ohtsubo K,Hagen FK,Ditto D,Zarbock A,Schaerli P,von Andrian UH,Ley K,Le D,Tabak LA,Marth JD
14-5931 was used in Flow cytometry/Cell sorting to find that ppGalNAcT-1 plays key roles in cell and glycoprotein selective functions that modulate the haematopoietic system.
Sat Dec 01 00:00:00 UTC 2007
The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.
International journal of experimental pathology
DuPré SA,Redelman D,Hunter KW
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 14-5931-82) in Flow Cytometry
Mon Oct 01 00:00:00 UTC 2007
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation.
American journal of physiology. Lung cellular and molecular physiology
Fan J,Li Y,Vodovotz Y,Billiar TR,Wilson MA
Sat Apr 01 00:00:00 UTC 2006
p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo.
Molecular and cellular biology
Soeiro I,Mohamedali A,Romanska HM,Lea NC,Child ES,Glassford J,Orr SJ,Roberts C,Naresh KN,Lalani el-N,Mann DJ,Watson RJ,Thomas NS,Lam EW
14-5931 was used in Magnetic cell separation to provide genetic and molecular evidence to demonstrate that p130 is a cyclin-dependent kinase inhibitor, and cooperates with p27Kip1 to regulate hematopoietic cell proliferation in vivo.
Tue Aug 01 00:00:00 UTC 2006
Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRObeta/CXCL2 and GRObetaT/CXCL2delta4.
Blood
Pelus LM,Bian H,King AG,Fukuda S
14-5931 was used in Functional assays to indicate that polymorphonuclear neutrophils are a common target for granulocyte colony-stimulating factor and GRObeta/GRObetaT-mediated peripheral blood stem cells mobilisation.
Thu Jan 01 00:00:00 UTC 2004
Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils.
The Journal of experimental medicine
Zhou JS,Friend DS,Feldweg AM,Daheshia M,Li L,Austen KF,Katz HR
14-5931 was used in Neutralization experiments to investigate the role of gp49B1 in neutrophils, showing that gp49B1 expression on neutrophils suppresses LPS-induced microangiopathy.
Mon Oct 20 00:00:00 UTC 2003
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-RB6-8C5-RE-AV-20170920122035.jpg?time=20250104?time=20250104 "Ly-6G/Ly-6C Antibody (14-5931-82)")
