Invitrogen

Lymphotactin Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-95300

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

ELISA (ELISA)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human Lymphotactin recombinant protein (Position: V22-G114).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807104

Product Specific Information

Human Lymphotactin shares 60.2% and 57% amino acid (aa) sequence identity with mouse and rat Lymphotactin, respectively.

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: HELA whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Lymphotactin, otherwise known as XCL1, is a member of the C-chemokine family that uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation. Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATAC; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; Lymphotactin; Lymphotaxin; SCM-1-alpha; SCM-1-beta; SCM-1alpha; SCM-1beta; SCM1alpha; SCM1beta; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); Small-inducible cytokine C1; XC chemokine ligand 1

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Gene Aliases: ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCM1A; SCYC1; XCL1

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UniProt ID: (Human) P47992

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Entrez Gene ID: (Human) 6375

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Function(s)
chemokine activity chemokine receptor binding protein homodimerization activity CCR chemokine receptor binding
Process(es)
positive regulation of T cell mediated cytotoxicity monocyte chemotaxis positive regulation of leukocyte chemotaxis negative regulation of T cell cytokine production positive regulation of T cell cytokine production negative regulation of T-helper 1 type immune response signal transduction G-protein coupled receptor signaling pathway cell-cell signaling response to virus positive regulation of T cell chemotaxis neutrophil chemotaxis negative regulation of interferon-gamma production negative regulation of interleukin-2 production positive regulation of interleukin-10 production mature natural killer cell chemotaxis negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of GTPase activity negative regulation of transcription, DNA-templated regulation of inflammatory response positive regulation of inflammatory response release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-4 cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta production positive regulation of granzyme B production positive regulation of neutrophil chemotaxis positive regulation of thymocyte migration positive regulation of natural killer cell chemotaxis positive regulation of granzyme A production negative regulation of T-helper 1 cell activation positive regulation of B cell chemotaxis positive regulation of T-helper 2 cell cytokine production positive regulation of T-helper 1 cell cytokine production positive regulation of immunoglobulin production in mucosal tissue negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell proliferation
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