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Proteintech
MAD2L1 Monoclonal Antibody (2F5F12)
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Product Details
66014-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2F5F12
Immunogen
MAD2L1 Fusion Protein Ag17512 (16-185 aa encoded by BC000356)
Conjugate
Form
Liquid
Concentration
1.07 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SAEIVAEFF SFGINSILYQ RGIYPSETFT RVQKYGLTLL VTTDLELIKY LNNVVEQLKD WLYKCSVQKL VVVISNIESG EVLERWQFDI ECDKTAKDDS APREKSQKAI QDEIRSVIRQ ITATVTFLPL LEVSCSFDLL IYTDKDLVVP EKWEESGPQF ITNSEEVRLR S (16-185 aa encoded by BC000356)
Target Information
Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsMAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; MadL1; Mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; Mitotic spindle assembly checkpoint protein MAD2A
Gene Aliases: HSMAD2; MAD2; MAD2L1
UniProt ID: (Human) Q13257
Entrez Gene ID: (Human) 4085
mitotic sister chromatid segregation
sister chromatid cohesion
mitotic cell cycle checkpoint
mitotic spindle assembly checkpoint
anaphase-promoting complex-dependent catabolic process
negative regulation of protein catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of mitotic cell cycle
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
positive regulation of mitotic cell cycle spindle assembly checkpoint
negative regulation of ubiquitin protein ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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