Proteintech

MAD2L2 Polyclonal Antibody

MAD2L2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MAD2L2 Antibody (12683-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using (Product # 12683-1-AP) (MAD2L2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

MAD2L2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12683-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 15 publications 15 publications

Immunohistochemistry (IHC)

Assay-dependent

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAD2L2 Fusion Protein Ag3373 (2-211 aa encoded by BC015244)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TTLTRQDLN FGQVVADVLC EFLEVAVHLI LYVREVYPVG IFQKRKKYNV PVQMSCHPEL NQYIQDTLHC VKPLLEKNDV EKVVVVILDK EHRPVEKFVF EITQPPLLSI SSDSLLSHVE QLLRAFILKI SVCDAVLDHN PPGCTFTVLV HTREAATRNM EKIQVIKDFP WILADEQDVH MHDPRLIPLK TMTSDILKMQ LYVEERAHKG S (2-211 aa encoded by BC015244)

Target Information

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis.

Cell death & disease

Chen Y,Jie X,Xing B,Wu Z,Yang X,Rao X,Xu Y,Zhou D,Dong X,Zhang T,Yang K,Li Z,Wu G

Thu Feb 03 00:00:00 UTC 2022

Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage.

Molecules (Basel, Switzerland)

Pernicone N,Elias M,Onn I,Tobi D,Listovsky T

Wed Jan 19 00:00:00 UTC 2022

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.

Nature communications

Vincendeau E,Wei W,Zhang X,Planchais C,Yu W,Lenden-Hasse H,Cokelaer T,Pipoli da Fonseca J,Mouquet H,Adams DJ,Alt FW,Jackson SP,Balmus G,Lescale C,Deriano L

Tue Jun 28 00:00:00 UTC 2022

Chromosome alignment-maintaining phosphoprotein CHAMP1 plays a role in cell survival through regulating Mcl-1 expression.

Cancer science

Hino M,Iemura K,Ikeda M,Itoh G,Tanaka K

Wed Sep 01 00:00:00 UTC 2021

MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.

International journal of biological sciences

Bao D,Su H,Lei CT,Tang H,Ye C,Xiong W,He FF,Lin JH,Hammes HP,Zhang C

Mon Dec 20 00:00:00 UTC 2021

MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.

International journal of biological sciences

Bao D,Su H,Lei CT,Tang H,Ye C,Xiong W,He FF,Lin JH,Hammes HP,Zhang C

Mon Dec 20 00:00:00 UTC 2021

MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.

International journal of biological sciences

Bao D,Su H,Lei CT,Tang H,Ye C,Xiong W,He FF,Lin JH,Hammes HP,Zhang C

Mon Dec 20 00:00:00 UTC 2021

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.

Nature communications

de Krijger I,Föhr B,Pérez SH,Vincendeau E,Serrat J,Thouin AM,Susvirkar V,Lescale C,Paniagua I,Hoekman L,Kaur S,Altelaar M,Deriano L,Faesen AC,Jacobs JJL

Tue Sep 14 00:00:00 UTC 2021

Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Song AN,Yin XJ,Gao P,Tang H,Meng XF,Zhang C

Mon Nov 01 00:00:00 UTC 2021

Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.

Journal of medicinal chemistry

Zhang J,Zou L,Shi D,Liu J,Zhang J,Zhao R,Wang G,Zhang L,Ouyang L,Liu B

Thu Oct 14 00:00:00 UTC 2021

CDH1 binds MAD2L2 in a Rev1-like pattern.

Biochemical and biophysical research communications

Pernicone N,Grinshpon S,Listovsky T

Thu Oct 22 00:00:00 UTC 2020

Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.

Cell reports

Gray S,Santiago ER,Chappie JS,Cohen PE

Tue Jul 07 00:00:00 UTC 2020

MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.

Molecular oncology

Li Y,Li L,Chen M,Yu X,Gu Z,Qiu H,Qin G,Long Q,Fu X,Liu T,Li W,Huang W,Shi D,Kang T,Luo M,Wu X,Deng W

Thu Mar 01 00:00:00 UTC 2018

MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.

Molecular oncology

Li Y,Li L,Chen M,Yu X,Gu Z,Qiu H,Qin G,Long Q,Fu X,Liu T,Li W,Huang W,Shi D,Kang T,Luo M,Wu X,Deng W

Thu Mar 01 00:00:00 UTC 2018

MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.

Molecular oncology

Li Y,Li L,Chen M,Yu X,Gu Z,Qiu H,Qin G,Long Q,Fu X,Liu T,Li W,Huang W,Shi D,Kang T,Luo M,Wu X,Deng W

Thu Mar 01 00:00:00 UTC 2018

MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.

Molecular oncology

Li Y,Li L,Chen M,Yu X,Gu Z,Qiu H,Qin G,Long Q,Fu X,Liu T,Li W,Huang W,Shi D,Kang T,Luo M,Wu X,Deng W

Thu Mar 01 00:00:00 UTC 2018

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.

Nucleic acids research

Tomida J,Takata K,Lange SS,Schibler AC,Yousefzadeh MJ,Bhetawal S,Dent SY,Wood RD

Thu Jan 01 00:00:00 UTC 2015

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.

Nucleic acids research

Tomida J,Takata K,Lange SS,Schibler AC,Yousefzadeh MJ,Bhetawal S,Dent SY,Wood RD

Thu Jan 01 00:00:00 UTC 2015

Regulation of error-prone translesion synthesis by Spartan/C1orf124.

Nucleic acids research

Kim MS,Machida Y,Vashisht AA,Wohlschlegel JA,Pang YP,Machida YJ

Fri Feb 01 00:00:00 UTC 2013

Regulation of error-prone translesion synthesis by Spartan/C1orf124.

Nucleic acids research

Kim MS,Machida Y,Vashisht AA,Wohlschlegel JA,Pang YP,Machida YJ

Fri Feb 01 00:00:00 UTC 2013

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.

The Journal of cell biology

Listovsky T,Sale JE

Mon Oct 14 00:00:00 UTC 2013

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.

The Journal of cell biology

Listovsky T,Sale JE

Mon Oct 14 00:00:00 UTC 2013

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.

The Journal of cell biology

Listovsky T,Sale JE

Mon Oct 14 00:00:00 UTC 2013

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.

The Journal of cell biology

Listovsky T,Sale JE

Mon Oct 14 00:00:00 UTC 2013

REV1 and polymerase ζ facilitate homologous recombination repair.

Nucleic acids research

Sharma S,Hicks JK,Chute CL,Brennan JR,Ahn JY,Glover TW,Canman CE

Sun Jan 01 00:00:00 UTC 2012

REV1 and polymerase ζ facilitate homologous recombination repair.

Nucleic acids research

Sharma S,Hicks JK,Chute CL,Brennan JR,Ahn JY,Glover TW,Canman CE

Sun Jan 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; Mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; REV7 homolog; RP3-330O12.4

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Gene Aliases: 2310033C13Rik; G1-453-4; MAD2B; MAD2L2; POLZ2; repro22; REV7

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UniProt ID: (Human) Q9UI95, (Rat) D3Z8D9, (Mouse) Q9D752

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Entrez Gene ID: (Human) 10459, (Rat) 313702, (Mouse) 71890

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Function(s)

RNA polymerase II activating transcription factor binding protein binding JUN kinase binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MAD2L2 Polyclonal Antibody

MAD2L2 Antibody (12683-1-AP) in IHC (P)

Product Details

12683-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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