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Invitrogen
MAD2L2 Recombinant Rabbit Monoclonal Antibody (JU99-23)
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Product Details
MA5-32822
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JU99-23
Immunogen
Synthetic peptide within Human Mad2L2 aa 162-211
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2810098
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; Mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; REV7 homolog; RP3-330O12.4
Gene Aliases: 2310033C13Rik; G1-453-4; MAD2B; MAD2L2; POLZ2; repro22; REV7
UniProt ID: (Human) Q9UI95, (Rat) D3Z8D9, (Mouse) Q9D752
Entrez Gene ID: (Human) 10459, (Rat) 313702, (Mouse) 71890
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
double-strand break repair
transcription, DNA-templated
actin filament organization
mitotic nuclear division
negative regulation of epithelial to mesenchymal transition
negative regulation of transcription by competitive promoter binding
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein catabolic process
DNA damage response, signal transduction resulting in transcription
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
cell division
negative regulation of canonical Wnt signaling pathway
negative regulation of ubiquitin protein ligase activity
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of transcription regulatory region DNA binding
mitotic spindle assembly checkpoint
error-prone translesion synthesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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