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Immunogen sequence: FSAVREDFKD LKPQLWNAVD EEICLAECDI YSYNPDLDSD PFGEDGSLWS FNYFFYNKRL KRIVFFSC
Antigen sequence identity: Mouse 99%; Rat 99%
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homolog of yeast MAF1; MAF1 negative regulator of RNA polymerase III; Repressor of RNA polymerase III transcription MAF1 homolog
Gene Aliases: MAF1
UniProt ID: (Human) Q9H063
Entrez Gene ID: (Human) 84232
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