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Invitrogen
MAGEA3 Chimeric Recombinant Rabbit Monoclonal Antibody (21B4)
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FIGURE: 1 / 3
MAGEA3 Chimeric Antibody (MA5-51710) in ICC/IF
Immunocytochemistry analysis of MAGEA3 in paraformaldehyde fixed HeLa cells using MAGEA3 Chimeric Recombinant Rabbit Monoclocal Antibody (Product # MA5-51710) at a 1:1,000 dilution for 1h followed by Alexa Fluor 488 secondary antibody (1:1,500 dilution), showing nuclear staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom: primary antibody, DAPI, merged channels and an isotype... View More
Product Details
MA5-51710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
21B4
Immunogen
The original antibody was isolated from a patient suffering from a tumor expressing a tumor specific antigen like MAGE-A3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3250402
Product Specific Information
This antibody binds human MAGEA3 and MAGEA6, but does not cross react with other members of the MAGE family like MAGE-A1, MAGE-A4 and MAGE-A10. MAGE-A3 is a tumor specific antigen and it is expressed on many tumors like melanoma, non-small cell lung cancer, hematologic malignancies, and others.
Target Information
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antigen MZ2-D; Cancer/testis antigen 1.3; cancer/testis antigen family 1, member 3; CT1.3; MAGE-3 antigen; melanoma antigen family A, 3; melanoma antigen family A3; Melanoma-associated antigen 3; MGC14613
Gene Aliases: CT1.3; HIP8; HYPD; MAGE3; MAGEA3; MAGEA6
UniProt ID: (Human) P43357
Entrez Gene ID: (Human) 4102
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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