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Immunogen sequence: MAQKMDCGA GLLGFQNPDA CRAVCHPLPQ PPASTLPLSA FPTLCDPPYS QLRDPPAVLS CYCTPLGASP APAEASVEDS ALLMQTLMEA IQISEAPPTN QATAAASPQS SQPPTANEMA DIQVSAAAAR PKSAFKVQNA TTKGPNGVYD FSQAHNAKDV PNTQPKAAFK SQNATPKGPN AAYDFSQAAT TGELAANKSE MAFKAQNATT KVGPNATYNF SQSLNANDLA NSRPKTPFKA WNDTTKAPTA DTQTQNVNQA KMATSQADIE TDPGISEPDG ATAQTSADGS QAQNLESRTI IRGKRTRKIN NLNVEENSSG DQRRAPLAAG TWRSAPVPVT TQNPPGA (1-346 aa encoded by BC014070)
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
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Protein Aliases: 11B6; BCG-1; Dlxin-1; JCL-1; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged2; melanoma antigen family D, 1; melanoma antigen family D1; Melanoma-associated antigen D1; Neurotrophin receptor-interacting MAGE homolog; Sertoli cell necdin-related gene protein 1; SNERG-1
Gene Aliases: 2810433C11Rik; 5430405L04Rik; Dlixin; DLXIN-1; Dlxin1; DXBwg1492e; MAGE-D1; MAGED1; mFLJ00163; NRAGE; PP2250; PRO2292
UniProt ID: (Human) Q5VSH6, (Mouse) Q9QYH6, (Rat) Q9ES73
Entrez Gene ID: (Human) 9500, (Mouse) 94275, (Rat) 84469
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