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Invitrogen
MAGED1/MAGED2 Polyclonal Antibody
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MAGED1/MAGED2 Antibody (PA5-23347) in WB
Western blot analysis of MAGED1/MAGED2 in A375 cell lysate. Samples were incubated in MAGED1/MAGED2 polyclonal antibody (Product # PA5-23347) using a dilution of 5 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
Product Details
PA5-23347
Product Specifications
Species Reactivity
Dog,
Horse,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
human MAGE-D2 was used as the immunogen.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540871
Target Information
MAGE-D2, also known as Melanoma-associated antigen D2, belongs to the melanoma antigen encoding gene (MAGE) family with a MAGE domain. Rat and mouse orthologues have been isolated. Compared to other proteins (MAGE-A, MAGE- B and MAGE-C clusters) MAGE-D2 is expressed ubiquitously. This intracellular protein shows high expression in specific brain regions and in the interstitium of testes. Though the exact function of this protein is yet to be deduced, MAGE-D2 is considered as a hot spot for X-linked mental retardation. Research reveals that MAGE-D2 might have some role in breast and gastric cancer, as well as in hepatocellular carcinoma. MAGE-D2 is also known to interact physically with p53 and modify its activity, thus acting as a p53-dissociator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11B6; BCG-1; Breast cancer-associated gene 1 protein; Dlxin-1; Hepatocellular carcinoma-associated protein JCL-1; JCL-1; MAGE tumor antigen CCF; MAGE-D1 antigen; MAGE-D2 antigen; melanoma antigen family D, 1; melanoma antigen family D, 2; melanoma antigen family D1; melanoma antigen family D2; Melanoma-associated antigen D1; Melanoma-associated antigen D2; Neurotrophin receptor-interacting MAGE homolog; Sertoli cell necdin-related gene protein 1; SNERG-1
Gene Aliases: 11B6; 2810433C11Rik; 4833439A22Rik; 5430405L04Rik; BARTS5; BCG-1; BCG1; Dlixin; DLXIN-1; Dlxin1; DXBwg1492e; HCA10; MAGE-D1; MAGE-D2; MAGED1; MAGED2; mFLJ00163; NRAGE; ORF1; PP2250; PRO2292
UniProt ID: (Human) Q5VSH6, (Human) Q9UNF1, (Mouse) Q9QYH6, (Rat) Q9ES73
Entrez Gene ID: (Dog) 480923, (Human) 9500, (Human) 10916, (Mouse) 94275, (Rat) 84469, (Mouse) 80884, (Rat) 113947
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
circadian regulation of gene expression
regulation of circadian rhythm
regulation of apoptotic process
positive regulation of MAP kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of epithelial cell proliferation
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of apoptotic signaling pathway
biological_process
rhythmic process
JUN phosphorylation
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