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Product Details
PA5-57911
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MAN2B2. Recombinant protein control fragment (Product #RP-96590).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2643723
Product Specific Information
Immunogen sequence: LLCHRIEQEY QAGPLELNRE AVLRTSTNLN SQQVIYSDNN GYQMQRRPYV SYVNNSIARN YYPMVQSAFM EDGKSRLVLL SERAHGISSQ GNGQVE
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 78%.
Target Information
The MAN2B2 (Mannosidase Alpha Class 2B Member 2) gene encodes an enzyme that is involved in the processing and modification of glycoproteins by hydrolyzing alpha-mannosidic linkages. Located on chromosome 4, the MAN2B2 protein is crucial for proper lysosomal function and is part of the glycosyl hydrolase family. Pathogenic variants in the MAN2B2 gene have been linked to a rare congenital disorder of glycosylation (CDG), known as MAN2B2-CDG, characterized by immune deficiency, developmental delay, stroke, and dysmorphic facial features. These mutations lead to an altered mannosylation profile, impacting glycoprotein processing and cellular functions. Studies have shown that reintroducing wild-type MAN2B2 can restore the normal mannosylation profile in patient cells, highlighting its therapeutic potential. Furthermore, recent research has identified circular RNA from this gene (circMAN2B2) that is implicated in the proliferation of hepatocellular carcinoma cells, suggesting a role in cancer biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-1,6-mannosidase; core-specific lysosomal alpha-1,6-Mannosidase; Epididymis-specific alpha-mannosidase; HMG17L3; Mannosidase alpha class 2B member 2; mannosidase, alpha, class 2B, member 2; NHC
Gene Aliases: KIAA0935; MAN2B2
UniProt ID: (Human) Q9Y2E5
Entrez Gene ID: (Human) 23324
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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