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MAP1B Polyclonal Antibody

MAP1B Antibody in Immunocytochemistry (ICC/IF)

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MAP1B Antibody (21633-1-AP) in ICC/IF

Immunofluorescent analysis of SH-SY5Y cells using 21633-1-AP (MAP1B antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MAP1B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MAP1B Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

21633-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:10-1:100

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAP1B Fusion Protein Ag16255 (414-567 aa encoded by BC141853)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DSRESLKPA AKPLPSKSVR KESKEETPEV TKVNHVEKPP KVESKEKVMV KKDKPVKTET KPSVTEKEVP SKEEPSPVKA EVAEKQATDV KPKAAKEKTV KKETKVKPED KKEEKEKPKK EVAKKEDKTP IKKEEKPKKE EVKKEVKKEI KKEEK (414-567 aa encoded by BC141853)

Target Information

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons.

Cell death discovery

Garone MG,Salerno D,Rosa A

Thu Jan 26 00:00:00 UTC 2023

Endothelin-1, over-expressed in SOD1^G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis.

Frontiers in cellular neuroscience

Zhang Y,Chen L,Li Z,Li D,Wu Y,Guo Y

Thu Dec 22 00:00:00 UTC 2022

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.

Life science alliance

Strohm L,Hu Z,Suk Y,Rühmkorf A,Sternburg E,Gattringer V,Riemenschneider H,Berutti R,Graf E,Weishaupt JH,Brill MS,Harbauer AB,Dormann D,Dengjel J,Edbauer D,Behrends C

Tue Nov 01 00:00:00 UTC 2022

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.

Life science alliance

Strohm L,Hu Z,Suk Y,Rühmkorf A,Sternburg E,Gattringer V,Riemenschneider H,Berutti R,Graf E,Weishaupt JH,Brill MS,Harbauer AB,Dormann D,Dengjel J,Edbauer D,Behrends C

Tue Nov 01 00:00:00 UTC 2022

SMN loss dysregulates microtubule-associated proteins in spinal muscular atrophy model.

Molecular and cellular neurosciences

Zobaroğlu Özer P,Koyunoğlu D,Son ÇD,Erdem-Yurter H,Bora G

Sun May 01 00:00:00 UTC 2022

Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.

Human molecular genetics

Bora G,Hensel N,Rademacher S,Koyunoğlu D,Sunguroğlu M,Aksu-Mengeş E,Balcı-Hayta B,Claus P,Erdem-Yurter H

Thu Feb 25 00:00:00 UTC 2021

FMRP and MOV10 regulate Dicer1 expression and dendrite development.

PloS one

Lannom MC,Nielsen J,Nawaz A,Shilikbay T,Ceman S

Tue Jan 18 00:00:00 UTC 2022

Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.

JCI insight

Cui L,Zheng J,Zhao Q,Chen JR,Liu H,Peng G,Wu Y,Chen C,He Q,Shi H,Yin S,Friedman RA,Chen Y,Guan MX

Thu Dec 03 00:00:00 UTC 2020

FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight.

Neurochemistry international

Long JY,Jiang W,Xia HB,Fu JY,Lu P,Hu F,Feng WC,Sun WW,Gao MM,Yi YH,Long YS

Sun Nov 01 00:00:00 UTC 2020

FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight.

Neurochemistry international

Long JY,Jiang W,Xia HB,Fu JY,Lu P,Hu F,Feng WC,Sun WW,Gao MM,Yi YH,Long YS

Sun Nov 01 00:00:00 UTC 2020

MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.

EMBO reports

Arasaki K,Nagashima H,Kurosawa Y,Kimura H,Nishida N,Dohmae N,Yamamoto A,Yanagi S,Wakana Y,Inoue H,Tagaya M

Wed Aug 01 00:00:00 UTC 2018

MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.

EMBO reports

Arasaki K,Nagashima H,Kurosawa Y,Kimura H,Nishida N,Dohmae N,Yamamoto A,Yanagi S,Wakana Y,Inoue H,Tagaya M

Wed Aug 01 00:00:00 UTC 2018

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

Cerebral cortex (New York, N.Y. : 1991)

Heise C,Taha E,Murru L,Ponzoni L,Cattaneo A,Guarnieri FC,Montani C,Mossa A,Vezzoli E,Ippolito G,Zapata J,Barrera I,Ryazanov AG,Cook J,Poe M,Stephen MR,Kopanitsa M,Benfante R,Rusconi F,Braida D,Francolini M,Proud CG,Valtorta F,Passafaro M,Sala M,Bachi A,Verpelli C,Rosenblum K,Sala C

Wed Mar 01 00:00:00 UTC 2017

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

Cerebral cortex (New York, N.Y. : 1991)

Wed Mar 01 00:00:00 UTC 2017

GIT1 enhances neurite outgrowth by stimulating microtubule assembly.

Neural regeneration research

Li YS,Qin LX,Liu J,Xia WL,Li JP,Shen HL,Gao WQ

Tue Mar 01 00:00:00 UTC 2016

GIT1 enhances neurite outgrowth by stimulating microtubule assembly.

Neural regeneration research

Li YS,Qin LX,Liu J,Xia WL,Li JP,Shen HL,Gao WQ

Tue Mar 01 00:00:00 UTC 2016

Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.

Cell cycle (Georgetown, Tex.)

Wu J,He Z,Wang DL,Sun FL

Tue Nov 01 00:00:00 UTC 2016

Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.

Cell cycle (Georgetown, Tex.)

Wu J,He Z,Wang DL,Sun FL

Tue Nov 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: DKFZp686E1099; DKFZp686F1345; FLJ38954; MAP-1B; MAP1(X); MAP1.2; Microtubule-associated protein 1B; Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)); microtubule-associated protein 5; protein phosphatase 1, regulatory subunit 102

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Gene Aliases: A230055D22; AI843217; FUTSCH; LC1; MAP1B; MAP5; Mtap-5; Mtap1b; Mtap5; PPP1R102

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UniProt ID: (Human) P46821, (Mouse) P14873

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Entrez Gene ID: (Human) 4131, (Mouse) 17755

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Function(s)

structural molecule activity protein binding microtubule binding actin binding cytoskeletal regulatory protein binding phospholipid binding protein complex binding

Process(es)

microtubule cytoskeleton organization microtubule bundle formation microtubule-based process negative regulation of microtubule depolymerization nervous system development axonogenesis cellular process dendrite development positive regulation of microtubule polymerization negative regulation of intracellular transport positive regulation of neuron differentiation positive regulation of axon extension mitochondrion transport along microtubule axon extension establishment of monopolar cell polarity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MAP1B Polyclonal Antibody

MAP1B Antibody (21633-1-AP) in ICC/IF

Product Details

21633-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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