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OriGene
MAP2K2 Monoclonal Antibody (OTI5G8), TrueMAB™
Product Details
TA505716
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI5G8
Immunogen
Full length human recombinant protein of human MAP2K2 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that is known to play a critical role in mitogen growth factor signal transduction. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity mitogen activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; ERK kinase 2; FLJ26075; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP2K1; MAPK; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; MEK2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK1; OTTHUMP00000165827; PRKMK1; protein kinase, mitogen activated, kinase 2, p45
Gene Aliases: AA589381; CFC4; MAP2K2; MAPKK2; MEK2; MK2; MKK2; PRKMK2
UniProt ID: (Dog) Q1HG70, (Human) P36507, (Rat) P36506, (Mouse) Q63932
Entrez Gene ID: (Dog) 611939, (Human) 5605, (Rat) 58960, (Mouse) 26396
protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
ATP binding
PDZ domain binding
protein complex scaffold
protein serine/threonine kinase activator activity
metal ion binding
scaffold protein binding
receptor signaling protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
activation of MAPK activity
regulation of mitotic cell cycle
heart development
negative regulation of gene expression
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
thyroid gland development
stress-activated protein kinase signaling cascade
activation of protein kinase activity
peptidyl-serine autophosphorylation
regulation of apoptotic process
thymus development
regulation of axon regeneration
positive regulation of axonogenesis
face development
trachea formation
epithelial cell proliferation involved in lung morphogenesis
ERK1 and ERK2 cascade
positive regulation of cell motility
MAPK cascade
protein phosphorylation
regulation of stress-activated MAPK cascade
lung morphogenesis
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
regulation of early endosome to late endosome transport
regulation of protein phosphorylation
phosphorylation
proteolysis in other organism
positive regulation of transcription, DNA-templated
positive regulation of ERK1 and ERK2 cascade
positive regulation of production of miRNAs involved in gene silencing by miRNA
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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