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Proteintech
MAP3K4 Polyclonal Antibody
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Product Details
21610-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAP3K4 Fusion Protein Ag16254 (825-1174 aa encoded by BC146770)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLEIAAEFR LSAPVRDLLD VLKSKQYVKV QIPGLENLQM FVPDTLAEEK SIILQLLNAA AGKDCSKDSD DVLIDAYLLL TKHGDRARDS EDSWGTWEAQ PVKVVPQVET VDTLRSMQVD NLLLVVMQSA HLTIQRKAFQ QSIEGLMTLC QEQTSSQPVI AKALQQLKND ALELCNRISN AIDRVDHMFT SEFDAEVDES ESVTLQQYYR EAMIQGYNFG FEYHKEVVRL MSGEFRQKIG DKYISFARKW MNYVLTKCES GRGTRPRWAT QGFDFLQAIE PAFISALPED DFLSLQALMN ECIGHVIGKP HSPVTGLYLA IHRNSPRPMK VPRCHSDPPN PHLIIPTPEG F (825-1174 aa encoded by BC146770)
Target Information
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; mitogen activated protein kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase 4; predicted protein of HQ0412; PRKMK4; SAPK/ERK kinase 1; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of; T-associated sex reversal
Gene Aliases: D17Rp17; D17Rp17e; KIAA0213; MAP3K4; MAPKKK4; Mek4b; MEKK 4; MEKK4; mKIAA0213; MTK1; PRO0412; RP17; Rp17a; Tas
UniProt ID: (Human) Q9Y6R4, (Mouse) O08648
Entrez Gene ID: (Human) 4216, (Mouse) 26407, (Rat) 308106
MAP kinase kinase kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
MAPK cascade
activation of MAPKK activity
placenta development
response to UV-C
regulation of gene expression
male germ-line sex determination
positive regulation of telomere maintenance via telomerase
intracellular signal transduction
positive regulation of JUN kinase activity
positive regulation of telomerase activity
chorionic trophoblast cell differentiation
positive regulation of p38MAPK cascade
positive regulation of telomere capping
activation of MAPK activity
protein phosphorylation
phosphorylation
determination of dorsal identity
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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