Proteintech

MAP4 Polyclonal Antibody

MAP4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MAP4 Antibody (11229-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using 11229-1-AP ( MAP4 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

MAP4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11229-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:600-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAP4 Fusion Protein Ag1741 (629-979 aa encoded by BC012794)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKTEG GGSEAPLCPG PPAGEEPAIS EAAPEAGAPT SASGLNGHPT LSGGGDQREA QTLDSQIQET SI (629-979 aa encoded by BC012794)

Target Information

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.

Journal of experimental & clinical cancer research : CR

Pan Y,Liu J,Gao Y,Guo Y,Wang C,Liang Z,Wu M,Qian Y,Li Y,Shen J,Lu C,Ma S

Wed Mar 29 00:00:00 UTC 2023

FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.

Journal of experimental & clinical cancer research : CR

Pan Y,Liu J,Gao Y,Guo Y,Wang C,Liang Z,Wu M,Qian Y,Li Y,Shen J,Lu C,Ma S

Wed Mar 29 00:00:00 UTC 2023

FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.

Journal of experimental & clinical cancer research : CR

Pan Y,Liu J,Gao Y,Guo Y,Wang C,Liang Z,Wu M,Qian Y,Li Y,Shen J,Lu C,Ma S

Wed Mar 29 00:00:00 UTC 2023

Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.

Journal of innate immunity

Luo X,Ji R,Liu Q,Xiao X,Song W,An H,Li Y,Zhou J

Tue Dec 26 00:00:00 UTC 2023

Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway.

Heliyon

Hu P,Zong B,Chen Q,Shao R,Chen M,Yang Y,Shao G

Wed Mar 01 00:00:00 UTC 2023

Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway.

Heliyon

Hu P,Zong B,Chen Q,Shao R,Chen M,Yang Y,Shao G

Wed Mar 01 00:00:00 UTC 2023

Comparative Proteomic Analysis Reveals the Effect of Selenoprotein W Deficiency on Oligodendrogenesis in Fear Memory.

Antioxidants (Basel, Switzerland)

Situ J,Huang X,Zuo M,Huang Y,Ren B,Liu Q

Thu May 19 00:00:00 UTC 2022

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA.

Brain : a journal of neurology

Božič J,Motaln H,Janež AP,Markič L,Tripathi P,Yamoah A,Aronica E,Lee YB,Heilig R,Fischer R,Thompson AJ,Goswami A,Rogelj B

Mon Apr 18 00:00:00 UTC 2022

Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules.

Ecotoxicology and environmental safety

Yuan J,Zhao Y,Bai Y,Gu J,Yuan Y,Liu X,Liu Z,Zou H,Bian J

Fri Nov 19 00:00:00 UTC 2021

The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability.

Journal of molecular cell biology

Wu Y,Ding Y,Zheng X,Liao K

Fri Jul 03 00:00:00 UTC 2020

The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability.

Journal of molecular cell biology

Wu Y,Ding Y,Zheng X,Liao K

Fri Jul 03 00:00:00 UTC 2020

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.

Acta neuropathologica

Allen M,Wang X,Serie DJ,Strickland SL,Burgess JD,Koga S,Younkin CS,Nguyen TT,Malphrus KG,Lincoln SJ,Alamprese M,Zhu K,Chang R,Carrasquillo MM,Kouri N,Murray ME,Reddy JS,Funk C,Price ND,Golde TE,Younkin SG,Asmann YW,Crook JE,Dickson DW,Ertekin-Taner N

Thu Nov 01 00:00:00 UTC 2018

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.

Acta neuropathologica

Thu Nov 01 00:00:00 UTC 2018

Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.

Disease markers

Xia X,He C,Wu A,Zhou J,Wu J

Tue Sep 18 00:00:00 UTC 2018

Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.

Disease markers

Xia X,He C,Wu A,Zhou J,Wu J

Tue Sep 18 00:00:00 UTC 2018

Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.

Disease markers

Xia X,He C,Wu A,Zhou J,Wu J

Tue Sep 18 00:00:00 UTC 2018

Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.

Disease markers

Xia X,He C,Wu A,Zhou J,Wu J

Tue Sep 18 00:00:00 UTC 2018

Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.

Frontiers in cellular and infection microbiology

Zan J,Liu S,Sun DN,Mo KK,Yan Y,Liu J,Hu BL,Gu JY,Liao M,Zhou JY

Wed Dec 27 00:00:00 UTC 2017

Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.

Frontiers in cellular and infection microbiology

Zan J,Liu S,Sun DN,Mo KK,Yan Y,Liu J,Hu BL,Gu JY,Liao M,Zhou JY

Wed Dec 27 00:00:00 UTC 2017

Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma.

Oncogene

Jiang YY,Shang L,Shi ZZ,Zhang TT,Ma S,Lu CC,Zhang Y,Hao JJ,Shi C,Shi F,Xu X,Cai Y,Jia XM,Zhan QM,Wang MR

Thu Sep 15 00:00:00 UTC 2016

Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma.

Oncogene

Jiang YY,Shang L,Shi ZZ,Zhang TT,Ma S,Lu CC,Zhang Y,Hao JJ,Shi C,Shi F,Xu X,Cai Y,Jia XM,Zhan QM,Wang MR

Thu Sep 15 00:00:00 UTC 2016

Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.

Urologic oncology

Ou Y,Zheng X,Gao Y,Shu M,Leng T,Li Y,Yin W,Zhu W,Huang Y,Zhou Y,Tang J,Qiu P,Yan G,Hu J,Ruan H,Hu H

Wed Jan 01 00:00:00 UTC 2014

Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.

Urologic oncology

Ou Y,Zheng X,Gao Y,Shu M,Leng T,Li Y,Yin W,Zhu W,Huang Y,Zhou Y,Tang J,Qiu P,Yan G,Hu J,Ruan H,Hu H

Wed Jan 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: MAP 4; MAP-4; Microtubule-associated protein 4

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Gene Aliases: AA407148; MAP-4; MAP4; Mtap-4; Mtap4

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UniProt ID: (Human) P27816, (Mouse) Q7TPC6, (Rat) Q5M7W5

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Entrez Gene ID: (Human) 4134, (Mouse) 17758, (Rat) 367171

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Function(s)

structural molecule activity protein binding microtubule binding poly(A) RNA binding tubulin binding

Process(es)

mitotic spindle organization microtubule sliding establishment of spindle orientation cell division neuron projection development negative regulation of nonmotile primary cilium assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MAP4 Polyclonal Antibody

MAP4 Antibody (11229-1-AP) in IHC (P)

Product Details

11229-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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