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Invitrogen
MAP4K5 Polyclonal Antibody
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Product Details
PA5-100734
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAP4K5(Accession Q9Y4K4), corresponding to amino acid residues R355-N405.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850237
Product Specific Information
Antibody detects endogenous levels of total MAP4K5.
Target Information
MAP4K5 (KHS1) is a serine/threonine kinase that belongs to the GCK family of kinases and has been implicated as an upstream regulator of MAP kinase signaling pathways. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for MAP4K5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: germinal center kinase-related; KHS; Kinase homologous to SPS1/STE20; map4k5; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5; Mitogen-activated protein kinase kinase kinase kinase 5
Gene Aliases: 4432415E19Rik; GCKR; KHS; KHS1; MAP4K5; MAPKKKK5
UniProt ID: (Human) Q9Y4K4, (Mouse) Q8BPM2
Entrez Gene ID: (Human) 11183, (Mouse) 399510
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
MAP kinase kinase kinase kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
activation of MAPKKK activity
protein phosphorylation
activation of JUN kinase activity
intracellular signal transduction
MAPK cascade
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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