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MORG1 is a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome.
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Protein Aliases: MAPK cascade scaffold protein; MAPK organizer 1; MGC4238; Mitogen-activated protein kinase organizer 1; WD repeat domain-containing protein 83; WD repeat protein Morg1
Gene Aliases: 1500041N16Rik; MORG1; RGD1306947; WDR83
UniProt ID: (Human) Q9BRX9, (Rat) Q5BLX8, (Mouse) Q9DAJ4
Entrez Gene ID: (Human) 84292, (Rat) 288924, (Mouse) 67836
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