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Fabgennix
MAPK10 Polyclonal Antibody
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Product Details
MAPK10-101Y
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 375-425 on human Mitogen-activated protein kinase 10.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; mitogen activated protein kinase 10; Mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; p54-beta; SAPK-beta; SAPK/Erk/kinase 2; SAPK1b; Stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3
Gene Aliases: C230008H04Rik; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; p493F12; p54bSAPK; PRKM10; SAPb; SAPK(beta); SAPK1B; SAPKC; Serk2
UniProt ID: (Human) P53779, (Mouse) Q61831, (Rat) P49187
Entrez Gene ID: (Human) 5602, (Mouse) 26414, (Rat) 25272
negative regulation of transcription from RNA polymerase II promoter
protein phosphorylation
JNK cascade
JUN phosphorylation
response to light stimulus
phosphorylation
regulation of circadian rhythm
locomotor rhythm
rhythmic process
activation of MAPK activity
signal transduction
Fc-epsilon receptor signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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