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Product Details
H00225689-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAPK15 (AAH28034, 1 a.a. approximately 277 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MCTVVDPRIV RRYLLRRQLG QGAYGIVWKA VDRRTGEVVA IKKIFDAFRD KTDAQRTFRE ITLLQEFGDH PNIISLLDVI RAENDRDIYL VFEFMGCPPS PPPPTAVRTL SADTDLNAVI RKGGLLQDVH VRSIFYQLLR ATRFLHSGHV VHRDQKPSNV LLDANCTVKL CDFGLARSLG DLPEGPEDQA VTEYVATRWY RAPEVLLSSH RYTLGVDMWS LGCILGEMLR GRPLFPGTST LHQLELILET IPPPSEEDLL ALGSGCRASV LHQLGSR
Target Information
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.11.24; ERK-7; ERK-8; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; Mitogen-activated protein kinase 15
Gene Aliases: ERK7; ERK8; MAPK15
UniProt ID: (Human) Q8TD08
Entrez Gene ID: (Human) 225689
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
positive regulation of protein phosphorylation
negative regulation of DNA replication
positive regulation of protein ubiquitination
positive regulation of telomere maintenance via telomerase
response to estradiol
positive regulation of protein catabolic process
protein autophosphorylation
positive regulation of telomerase activity
positive regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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